Results 51 to 60 of about 30,373 (294)

Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

Frontiers in Pharmacology, 2021
The gastrointestinal tract is particularly vulnerable to off-target effects of antineoplastic drugs because intestinal epithelial cells proliferate rapidly and have a complex immunological interaction with gut microbiota.
David Dahlgren, Markus Sjöblom, Per M Hellström, Hans Lennernäs   +3 more
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Management of Coronavirus Disease 2019 Patients With Lung Cancer: Experience From a Thoracic Oncology Center

Frontiers in Molecular Biosciences, 2021
BackgroundCancer patients appear to be at a higher risk of complications from coronavirus disease 2019 (COVID-19). Specific data related to lung cancer (LC) patient management, active treatment, and/or recent diagnosis are still very limited.
David Barros Coelho, David Barros Coelho, Vanessa Santos, David Araújo, Hélder Novais Bastos, Hélder Novais Bastos, Hélder Novais Bastos, Adriana Magalhães, Venceslau Hespanhol, Venceslau Hespanhol, Venceslau Hespanhol, Henrique Queiroga, Henrique Queiroga, Natália Cruz-Martins, Natália Cruz-Martins, Natália Cruz-Martins, Maria Gabriela O. Fernandes, Maria Gabriela O. Fernandes, Maria Gabriela O. Fernandes   +18 more
doaj   +1 more source

Bortezomib‐Induced Sweet's Syndrome Confirmed by Rechallenge [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106899/1/phar1383 ...
Cohen, Garcia-Navarro, Ginarte, Millennium Pharmaceuticals, Murase, Naranjo, Paiva, Paydas, Richardson, Roccaro, Villarrubia   +10 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Electroactive Metal–Organic Frameworks for Electrocatalysis

Advanced Functional Materials, EarlyView.
Electrocatalysis is crucial in sustainable energy conversion as it enables efficient chemical transformations. The review discusses how metal–organic frameworks can revolutionize this field by offering tailorable structures and active site tunability, enabling efficient and selective electrocatalytic processes.
Irena Senkovska, Yutong Luo, Ruyan Zhao, Jianjun Zhang, Mingchao Wang, Xinliang Feng, Eike Brunner, Stefan Kaskel   +7 more
wiley   +1 more source

Clinical profiles of adverse drug reactions spontaneously reported at a single Korean hospital dedicated to children with complex chronic conditions. [PDF]

PLoS ONE, 2017
Children with complex chronic conditions (CCC) are presumed to be vulnerable to adverse drug reactions (ADRs). The clinical profiles of ADRs in CCC are not well known.
Bomi Kim, Sunwha Zara Kim, Jin Lee, Ae Hee Jung, Sun-Hoi Jung, Hyeon-Joo Hahn, Hye Ryun Kang, Dong In Suh   +7 more
doaj   +1 more source

The Possible Role of Prescribing Medications, Including Central Nervous System Drugs, in Contributing to Male-Factor Infertility (MFI): Assessment of the Food and Drug Administration (FDA) Pharmacovigilance Database

Brain Sciences, 2023
Background: A wide range of medications may have a possible role in the development of male-factor infertility (MFI), including various antineoplastic agents, testosterone/anabolic steroids, immunosuppressive drugs/immunomodulators, glucocorticosteroids,
Sara Baldini, Ahmed Khattak, Paolo Capogrosso, Gabriele Antonini, Federico Dehò, Fabrizio Schifano, Nicolò Schifano   +6 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Interactions of beta-lactam antibiotics and antineoplastic agents [PDF]

Antimicrobial Agents and Chemotherapy, 1983
The in vitro interactions of four beta-lactam antibiotics and five antineoplastic agents were examined with 100 clinically isolated strains of four species of gram-negative bacilli. Generally, by the checkerboard dilution method, beta-lactam antibiotics, when tested in combination with mitomycin C, bleomycin, or 5-fluorouracil, showed synergistic ...
Y, Ueda, A, Saito, Y, Fukuoka, Y, Yamashiro, Y, Ikeda, H, Taki, T, Yasuda, I, Saikawa   +7 more
openaire   +2 more sources