Results 41 to 50 of about 22,504 (303)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Clinical Spectrum of Acquired Hypomagnesemia: From Etiology to Therapeutic Approaches

Biomedicines
Hypomagnesemia is a frequent and often underrecognized electrolyte disturbance with important clinical consequences, especially in hospitalized and critically ill patients.
Matteo Floris, Andrea Angioi, Nicola Lepori, Doloretta Piras, Gianfranca Cabiddu, Antonello Pani, Mitchell H. Rosner   +6 more
doaj   +1 more source

Expression and regulation of transmembrane transporters in healthy intestine and gastrointestinal diseases [PDF]

, 2006
Transmembrane transporters mediate energy dependent or independent translocation of drugs, potentially toxic compounds, and of various endogenous substrates such as bile acids and bilirubin across membranes.
Hruz, Petr
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Interactions of beta-lactam antibiotics and antineoplastic agents [PDF]

Antimicrobial Agents and Chemotherapy, 1983
The in vitro interactions of four beta-lactam antibiotics and five antineoplastic agents were examined with 100 clinically isolated strains of four species of gram-negative bacilli. Generally, by the checkerboard dilution method, beta-lactam antibiotics, when tested in combination with mitomycin C, bleomycin, or 5-fluorouracil, showed synergistic ...
Y, Ueda, A, Saito, Y, Fukuoka, Y, Yamashiro, Y, Ikeda, H, Taki, T, Yasuda, I, Saikawa   +7 more
openaire   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

Frontiers in Pharmacology, 2021
The gastrointestinal tract is particularly vulnerable to off-target effects of antineoplastic drugs because intestinal epithelial cells proliferate rapidly and have a complex immunological interaction with gut microbiota.
David Dahlgren, Markus Sjöblom, Per M Hellström, Hans Lennernäs   +3 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Management of Coronavirus Disease 2019 Patients With Lung Cancer: Experience From a Thoracic Oncology Center

Frontiers in Molecular Biosciences, 2021
BackgroundCancer patients appear to be at a higher risk of complications from coronavirus disease 2019 (COVID-19). Specific data related to lung cancer (LC) patient management, active treatment, and/or recent diagnosis are still very limited.
David Barros Coelho, David Barros Coelho, Vanessa Santos, David Araújo, Hélder Novais Bastos, Hélder Novais Bastos, Hélder Novais Bastos, Adriana Magalhães, Venceslau Hespanhol, Venceslau Hespanhol, Venceslau Hespanhol, Henrique Queiroga, Henrique Queiroga, Natália Cruz-Martins, Natália Cruz-Martins, Natália Cruz-Martins, Maria Gabriela O. Fernandes, Maria Gabriela O. Fernandes, Maria Gabriela O. Fernandes   +18 more
doaj   +1 more source

Síntese total dos alcolóides glutarimídicos: (+)1-(2-feniletil)-3-(dimetilamino)piperidina-2,6-diona (filantimida) e (2s)-2-Metil-N-[(3s)-2,6-dioxo-1-(2-feniletil)piperidin-3-il]butanamida (Julocrotina) [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Química.Este trabalho apresenta a síntese da (±) Filantimida (13), um alcalóide glutarimídico, presente no Phyllanthus
Silva, Luciano Luiz
core