Results 41 to 50 of about 338,615 (308)

Targeting antibiotics to households for trachoma control. [PDF]

, 2010
BACKGROUND: Mass drug administration (MDA) is part of the current trachoma control strategy, but it can be costly and results in many uninfected individuals receiving treatment.
Anthony W Solomon, Solomon, AW, David C. W. Mabey, Manoj Gambhir, Sheila K West, West, SK, Sheila K. West, Gambhir Manoj, Anthony W. Solomon, Bailey Robin L., Basáñez María-Gloria, María-Gloria Basáñez, Bailey, RL, David C W Mabey, Basanez, M-G, Isobel M. Blake, Basáñez, María-Gloria, Grassly, NC, Nicholas C Grassly, Mabey, DCW, Solomon, Anthony W, Gambhir, Manoj, Blake Isobel M., Blake, Isobel M, Solomon Anthony W., Burton, Matthew J, Burton Matthew J., Mabey David C. W., Grassly, Nicholas C, Robin L Bailey, Bailey, Robin L, Blake, IM, Gambhir, M, Matthew J. Burton, West, Sheila K, Grassly Nicholas C., Nicholas C. Grassly, Isobel M Blake, Matthew J Burton, Mabey, David CW, West Sheila K., Burton, MJ, Robin L. Bailey   +42 more
core   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Interactions of beta-lactam antibiotics and antineoplastic agents [PDF]

Antimicrobial Agents and Chemotherapy, 1983
The in vitro interactions of four beta-lactam antibiotics and five antineoplastic agents were examined with 100 clinically isolated strains of four species of gram-negative bacilli. Generally, by the checkerboard dilution method, beta-lactam antibiotics, when tested in combination with mitomycin C, bleomycin, or 5-fluorouracil, showed synergistic ...
Y, Ueda, A, Saito, Y, Fukuoka, Y, Yamashiro, Y, Ikeda, H, Taki, T, Yasuda, I, Saikawa   +7 more
openaire   +2 more sources

Imide and isatin derivatives as β-lactam mimics of β-lactam antibiotics [PDF]

, 2002
Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the ß-lactam antibiotics and their chemical and biological reactivity ...
Ronald H.B. Galt, Michael I. Page, Hadfield, Peter S., Page, Michael I., Peter S. Hadfield, Bartholomew Vilanova, Lorraine A. Casey, Galt, Ronald H.B., Casey, Lorraine A., Vilanova, Bartholomew, Galt, Ronald H. B.   +10 more
core   +4 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Acknowledgement to Reviewers of Antibiotics in 2013

, 2014
The editors of Antibiotics would like to express their sincere gratitude to the following reviewers for assessing manuscripts in ...
Antibiotics Editorial Office
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

Frontiers in Pharmacology, 2021
The gastrointestinal tract is particularly vulnerable to off-target effects of antineoplastic drugs because intestinal epithelial cells proliferate rapidly and have a complex immunological interaction with gut microbiota.
David Dahlgren, Markus Sjöblom, Per M Hellström, Hans Lennernäs   +3 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source