Chronic candidal osteomyelitis of mid face: A therapeutic dilemma
Journal of Oral Biology and Craniofacial Research, 2013 Numerous explanations have been proposed for the increase in fungal infections including the use of broad-spectrum antibiotics, antineoplastic agents and prosthetic devices.
Rishi Bali +3 more
doaj +1 more source
A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro [PDF]
, 2013 Recently, the World Health Organization approved the nifurtimox–eflornithine combination therapy for the treatment of human African trypanosomiasis, renewing interest in nitroheterocycle therapies for this and associated diseases.
Smith, Terry K +5 more
core +1 more source
Drug-induced QT interval prolongation in cancer patients
Oncology Reviews, 2011 Cancer patients are at an increased risk for QT interval prolongation and subsequent potentially fatal Torsade de pointes tachycardia due to the multiple drugs used for treatment of malignancies and the associated symptoms and complications.
Torben K. Becker, Sai-Ching J. Yeung
doaj +1 more source
Analysis of Utilization Pattern of Antimicrobial Agents: Amas in Burn Wards Along with Evaluation of Supply Chain Management in A Tertiary Care Teaching Hospital [PDF]
, 2022 Antimicrobial Agents are commonest used medicaments in all type of health faculty and specialty. It will not be trust worthy if one will say that he or she has not used Antibiotics in his life time or cannot claim that will not use antibiotics in future.
Dhone, P. (Pravin) +3 more
core +4 more sources
Drug cocktail optimization in chemotherapy of cancer. [PDF]
PLoS ONE, 2012 BACKGROUND: In general, drug metabolism has to be considered to avoid adverse effects and ineffective therapy. In particular, chemotherapeutic drug cocktails strain drug metabolizing enzymes especially the cytochrome P450 family (CYP).
Saskia Preissner +7 more
doaj +1 more source
Effects of antineoplastics, antibiotics and antidiabetics on acetaldehyde metabolism after alcohol ingestion. [PDF]
, 1998 The main purpose of this study was to evaluate the inhibitory effects of 5-fluorouracil antineoplastics, cephem antibiotics containing the methyltetrazolylthiol (MTT) group and antidiabetics on aldehyde dehydrogenase (ALDH) activity in vivo and in vitro.
Moriya, Fumio, Kan, Shin, Ishizu, Hideo
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Antibiotics in patients on chemotherapy; aspects on pharmacokinetic and pharmacodynamic interactions with antineoplastic drugs [PDF]
, 2002 The aims of these studies were to investigate the pharmacokinetics of two beta-lactam antibiotics in patients with fever and cytostatic-induced neutropenia and the influence of cytostatic-induced gastrointestinal damage on the absorption of co ...
Nyhlén, Anna
core
A Multi-Objective Approach for Anti-Osteosarcoma Cancer Agents Discovery through Drug Repurposing
Pharmaceuticals, 2020 Osteosarcoma is the most common type of primary malignant bone tumor. Although nowadays 5-year survival rates can reach up to 60–70%, acute complications and late effects of osteosarcoma therapy are two of the limiting factors in treatments. We developed
Alejandro Cabrera-Andrade +7 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source