Results 31 to 40 of about 22,504 (303)
Drug-induced QT interval prolongation in cancer patients
Oncology Reviews, 2011 Cancer patients are at an increased risk for QT interval prolongation and subsequent potentially fatal Torsade de pointes tachycardia due to the multiple drugs used for treatment of malignancies and the associated symptoms and complications.
Torben K. Becker, Sai-Ching J. Yeung
doaj +1 more source
Drug cocktail optimization in chemotherapy of cancer. [PDF]
PLoS ONE, 2012 BACKGROUND: In general, drug metabolism has to be considered to avoid adverse effects and ineffective therapy. In particular, chemotherapeutic drug cocktails strain drug metabolizing enzymes especially the cytochrome P450 family (CYP).
Saskia Preissner +7 more
doaj +1 more source
Analysis of Utilization Pattern of Antimicrobial Agents: Amas in Burn Wards Along with Evaluation of Supply Chain Management in A Tertiary Care Teaching Hospital [PDF]
, 2022 Antimicrobial Agents are commonest used medicaments in all type of health faculty and specialty. It will not be trust worthy if one will say that he or she has not used Antibiotics in his life time or cannot claim that will not use antibiotics in future.
Dhone, P. (Pravin) +3 more
core +3 more sources
, 2009 Background The effect of additional treatment strategies with antineoplastic agents on intraperitoneal tumor stimulating interleukin levels are unclear.
Willems Wilhelm +13 more
core +1 more source
A new cytotoxic phenylthiazoline, 4-methylaeruginoic acid, from Streptomyces sp. KCTC 9303
, 1997 4 methylaeruginoic acid; cytotoxic agent; phenylthiazoline derivative; unclassified drug; antibiotic biosynthesis; article; carbon nuclear magnetic resonance; physical chemistry; priority journal; proton nuclear magnetic resonance; streptomyces ...
Ick Dong Yoo +5 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A Multi-Objective Approach for Anti-Osteosarcoma Cancer Agents Discovery through Drug Repurposing
Pharmaceuticals, 2020 Osteosarcoma is the most common type of primary malignant bone tumor. Although nowadays 5-year survival rates can reach up to 60–70%, acute complications and late effects of osteosarcoma therapy are two of the limiting factors in treatments. We developed
Alejandro Cabrera-Andrade +7 more
doaj +1 more source
, 2002 Background: The bactericidal effect of some antibiotic and antineoplastic agents commonly used in clinical practice was investigated to analyse whether the combinations act synergistically, have indifferent or antagonistic antibacterial effects compared ...
Nilsson-Ehle, Ingrid +3 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source