Antibiotic Resistant Bloodstream Infections in Pediatric Patients Receiving Chemotherapy or Hematopoietic Stem Cell Transplant: Factors Associated with Development of Resistance, Intensive Care Admission and Mortality [PDF]
Antibiotics, 2021 Bloodstream infections (BSI) are a severe complication of antineoplastic chemotherapy or hematopoietic stem cell transplantation (HSCT), especially in the presence of antibiotic resistance (AR).
Elio Castagnola +23 more
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Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study [PDF]
Frontiers in Pharmacology, 2018 Polymyxins are currently used as the last-resort antibiotics against multidrug-resistant Acinetobacter baumannii. As resistance to polymyxins emerges in A. baumannii with monotherapy, combination therapy is often the only remaining treatment option.
Thien B. Tran +6 more
doaj +7 more sources
Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens [PDF]
Frontiers in Microbiology, 2018 Due to limited new antibiotics, polymyxins are increasingly used to treat multidrug-resistant (MDR) Gram-negative bacteria, in particular carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.
Thien B. Tran +9 more
doaj +5 more sources
Ceftazidime and cefepime antagonize 5-fluorouracil’s effect in colon cancer cells
BMC Cancer, 2022 Background Drug-drug interaction (DDI), which can occur at the pharmacokinetics and/or the pharmacodynamics (PD) levels, can increase or decrease the therapeutic or adverse response of a drug itself or a combination of drugs.
Christina Pfab +6 more
doaj +1 more source
Biological screening of a unique drug library targeting MRGPRX2
Frontiers in Immunology, 2022 BackgroundAllergic drug reaction or drug allergy is an immunologically mediated drug hypersensitivity reaction (DHR). G-protein coupled receptors (GPCRs) are common drug targets and communicate extracellular signals that initiate cellular responses ...
Fan Yang +8 more
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Frontiers in Pharmacology, 2023 Drug-induced acute kidney injury (DI-AKI) is one of the leading causes of kidney injury, is associated with high mortality and morbidity, and limits the clinical use of certain therapeutic or diagnostic agents, such as antineoplastic drugs, antibiotics ...
Jun Li +4 more
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Fungal Infections in the Elderly [PDF]
Afro-Egyptian Journal of Infectious and Endemic Diseases, 2013 Fungi are increasingly recognised as major pathogens in critically ill patients. Several reasons have been proposed for the increase in invasive fungal infections, including the use of antineoplastic and immunosuppressive agents, broad-spectrum ...
Dimitrios Arvanitakis +2 more
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Overview of Bioactive Fungal Secondary Metabolites: Cytotoxic and Antimicrobial Compounds
Antibiotics, 2022 Microorganisms are known as important sources of natural compounds that have been studied and applied for different purposes in distinct areas. Specifically, in the pharmaceutical area, fungi have been explored mainly as sources of antibiotics, antiviral,
Rafael Conrado +3 more
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Intracellular acidification is a hallmark of thymineless death in E. coli.
PLoS Genetics, 2022 Thymidine starvation causes rapid cell death. This enigmatic process known as thymineless death (TLD) is the underlying killing mechanism of diverse antimicrobial and antineoplastic drugs.
Alexandra Ketcham +2 more
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An overview of diagnosis and management of drug‐induced hypomagnesemia
Pharmacology Research & Perspectives, 2021 Magnesium (Mg) is commonly addressed as the “forgotten ion” in medicine. Nonetheless, hypomagnesemia should be suspected in clinical practice in patients with relevant symptomatology and also be considered a predisposing factor for the development of ...
George Liamis +3 more
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