Results 51 to 60 of about 22,637 (303)

Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review

open access: yesAdvanced Materials, EarlyView.
Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase   +6 more
wiley   +1 more source

Síntese total dos alcolóides glutarimídicos: (+)1-(2-feniletil)-3-(dimetilamino)piperidina-2,6-diona (filantimida) e (2s)-2-Metil-N-[(3s)-2,6-dioxo-1-(2-feniletil)piperidin-3-il]butanamida (Julocrotina) [PDF]

open access: yes, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Química.Este trabalho apresenta a síntese da (±) Filantimida (13), um alcalóide glutarimídico, presente no Phyllanthus
Silva, Luciano Luiz
core  

Management of Coronavirus Disease 2019 Patients With Lung Cancer: Experience From a Thoracic Oncology Center

open access: yesFrontiers in Molecular Biosciences, 2021
BackgroundCancer patients appear to be at a higher risk of complications from coronavirus disease 2019 (COVID-19). Specific data related to lung cancer (LC) patient management, active treatment, and/or recent diagnosis are still very limited.
David Barros Coelho   +18 more
doaj   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui   +14 more
wiley   +1 more source

Investigations of Natural Products from Bryozoa Inhabiting Aotearoa New Zealand [PDF]

open access: yes, 2012
Two species of bryozoa, Pterocella vesiculosa and Plumatella repens, were investigated in an endeavour to isolate and characterise novel secondary metabolites.
Andersen, Aaron John Christian
core  

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

open access: yesAdvanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang   +6 more
wiley   +1 more source

Biodegradabilidade do antineoplásico ciclofosfamida por processo anaeróbio [PDF]

open access: yes, 2007
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia AmbientalA ciclofosfamida (CF) é um antineoplásico derivado da mostarda nitrogenada, utilizada no tratamento de vários tipos de câncer.
Barreto, Patrícia Sobierajski
core  

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen   +19 more
wiley   +1 more source

Possible Potentiation of an Antitumor Agent by the Polyene Antibiotics [PDF]

open access: yes, 1974
v, 31 p.The hematologic neoplasms, which comprise the acute and chronic leukemias, myelomas and lymphomas, are responsible for 10% of all cancer deaths in adults and 50% of the cancer deaths in children.
Evans, Mark J.
core  

PATTERN OF SUSPECTED ADVERSE DRUG REACTIONS IN A TERTIARY CARE HOSPITAL – A CROSS-SECTIONAL STUDY [PDF]

open access: yes, 2021
Objective: The objective of the study was to study the pattern of suspected adverse drug reactions (ADRs) in a tertiary care hospital. Methods: This is a cross-sectional study conducted in the Department of Pharmacology of a Tertiary Care Teaching ...
KORUTHARA MOHANAN, LIMA   +2 more
core   +1 more source

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