Results 61 to 70 of about 1,625,451 (291)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Antimicrobial Activity of Microorganisms Isolated from the Soil of the Tropical Desert of the Sinai Peninsula

Антибиотики и Химиотерапия
Background. The spread of pathogenic antibiotic-resistant microorganisms often leads to the inefficiency of antimicrobial therapy. One of the solutions to this problem is the search for new active natural antibiotics.The aim of the study.
A. L. Kandyba, E. V. Khramtsova, B. F. Vasilyeva, Ju. V. Boykova, A. A. Glukhova, T. A. Efimenko, O. V. Efremenkova   +6 more
doaj   +1 more source

Removal of sulfamethoxazole and sulfapyridine by carbon nanotubes in fixed-bed columns [PDF]

, 2013
Sulfamethoxazole (SMX) and sulfapyridine (SPY), two representative sulfonamide antibiotics, have gained increasing attention because of the ecological risks these substances pose to plants, animals, and humans.
Chen, Hao, Gao, Bin, Li, Hui, Morales, Veronica L., Tian, Yuan, Wang, Yu   +5 more
core   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Pharmacokinetics of Olivamide after Bolus Administration in Rats and Rabbits (a Pilot Study)

Антибиотики и Химиотерапия, 2020
The pharmacokinetics of olivamide, a semisynthetic antitumor derivate of olivomycin A, were studied in rats and rabbits after bolus administration. Plasma concentrations of olivamide were determined by an HPLC assay.
Yu. A. Portnoy, S. A. Dovzhenko, M. B. Kobrin, M. I. Treshalin, V. A. Golobrodo, A. N. Tevyashova, A. A. Firsov   +6 more
doaj  

Predictors of Antibiotics Co-prescription with Antimalarials for Patients Presenting with Fever in Rural Tanzania. [PDF]

, 2013
Successful implementation of malaria treatment policy depends on the prescription practices for patients with malaria. This paper describes prescription patterns and assesses factors associated with co-prescription of antibiotics and artemether ...
A Mannan, Alexander N Dodoo, ANO Dodoo, B Ahsan, BK Abuaku, BP Mmbando, Brown Kigahe, C Watsierah, CIR Chandler, CIR Chandler, D Zurovac, Dan Kajungu, EME Van Bijnen, F Font, F Font, H Reyburn, H Reyburn, H Riaz, I Masanja, I Tamuno, Ifakara, IM Masanja, Irene Masanja, JR Torvi, JU Okebe, K Bashrahil, K Shamshy, KA Oshikoya, LEG Mboera, Majige Selemani, Mbaraka Amuri, MI Masanja, ML McMorrow, ML Mcmorrow, Mustafa Njozi, Mwageni, N Nshakira, National Malaria Control Programe (NMCP) [Tanania], National Malaria Control Programme (NMCP) [Tanzania], P Winskill, Rashid Khatib, Salim Abdula, TO Ogungbamigbe, VA Badar   +43 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

New Biologically Active Compounds in the Series of 3-(indol-1-yl)-, 3-(N-aminoaryl)-, and 3-(S-thioaryl)Maleimide Derivatives

Антибиотики и Химиотерапия, 2020
Novel compounds among 3,4-disubstituted maleimlde derivatives that reveal a pronounced antimicrobial activity in vitro against Gram-positive bacteria, yeast Candida albicans, and fungi Aspergillus niger were obtained through total chemical synthesis. All
S. A. Lakatosh, A. S'. Trenin, A. Yu. Simonov, S. N. Lavrenov, O. P. Bychkova, E. A. Tsvigun   +5 more
doaj  

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon [PDF]

, 2015
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia.
Clara Belzer, Giovannucci, Guido J. Hooiveld, Jan Dekker, Lapré, McGarr, Michael Müller, Michiel Kleerebezem, Noortje Ijssennagger, Roelof van der Meer, Saskia W. C. van Mil, Sesink, Sheffner, van Klinken   +13 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source