Results 81 to 90 of about 1,248,661 (298)

Applying psychological theory to evidence-based clinical practice : identifying factors predictive of managing upper respiratory tract infections without antibiotics [PDF]

, 2007
Background: Psychological models can be used to understand and predict behaviour in a wide range of settings. However, they have not been consistently applied to health professional behaviours, and the contribution of differing theories is not clear. The
Glidewell, Liz, Grimshaw, Jeremy, Johnston, Marie, Eccles, Martin P., Thomas, Ruth Elizabeth, Steen, Nick, MacLennan, Graeme Stewart, Bonetti, Debbie, Pitts, Nigel, Walker, Anne   +9 more
core   +2 more sources

Ascorbigen — Rifabutin Toxicity Modifier

Антибиотики и Химиотерапия, 2020
Relevance. Indications for rifabutin use are constantly expanding. It is used in the treatment of extremely complex nosological forms of infectious diseases. However, side effects of the medication, such as gastrointestinal toxicity and myelosuppression,
E. R. Pereverzeva, M. I. Treshchalin, I. D. Treshchalin   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Antibiotics in dentistry

, 2016
After conducting a thorough research on antibiotics in dentistry, it has been found that dentists play a very vital role in prescribing antibiotics and in its resistance. Diagnosis should be made to find the causative organism.
Joseph, Dona
core  

The 2025 CHINET surveillance report on bacterial resistance in China

One Health Advances
This study assessed the antimicrobial susceptibility of clinical bacterial isolates collected from Chinese medical institutions in 2025. Antimicrobial susceptibility testing was performed on isolates from 80 hospitals using disk diffusion or commercial ...
Li Ding, Yan Guo, Siquan Shen, Renru Han, Dandan Yin, Jinye Du, Xiuwen Xu, Yang Yang, Shi Wu, Demei Zhu, Fupin Hu   +10 more
doaj   +1 more source

The Effectiveness of the Combined Use of Meropenem and Avibactam Against Carbapenemase-Producing Klebsiella pneumoniae Strains in an in vitro Dynamic Model

Антибиотики и Химиотерапия
Background. Combinations of carbapenems with new-generation carbapenemase inhibitors are successfully used to combat infections caused by carbapenemase-producing Klebsiella pneumoniae strains. However, K.
E. N. Strukova, M. V. Golikova, M. B. Kobrin, S. A. Dovzhenko, A. V. Golyshkin, N. R. Almyasheva, Yu. A. Portnoy   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ANTIBACTERIAL PROPERTIES OF AMICOUMYCIN A

Антибиотики и Химиотерапия, 2020
The in vitro activity of the antibiotic amikumacin A against 22 collective test strains and 24 clinical isolates of bacteria and fungi was studied. It is shown that amicoumycin A has a broad antimicrobial spectrum of activity.
O. V. Efremenkova, N. I. Gabrielyan, I. A. Malanicheva, T. A. Efimenko, I. G. Sumarukova, A. A. Gluhova, YU. V. Boykova, E. A. Rogozhin, A. M. Korolev, V. A. Korshun, I. V. Drabkina   +10 more
doaj  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source