Results 81 to 90 of about 1,145,667 (304)

The pharmacokinetic-nephrotoxicity relationships of CMS and CMS-E2 from the perspective of plasma and kidney drug concentrations in rats

Scientific Reports
Nephrotoxicity has seriously affected the clinical application of colistin methanesulphonate (CMS). Colistin B methanesulphonate (CMS-E2) is a novel polymyxin developed and aimed to have lower nephrotoxicity.
Chenxue Guo, Lin Xi, Xingyi Qu, Zhiwei Huang, Size Li, Wanzhen Li, Xiaofen Liu, Jing Zhang   +7 more
doaj   +1 more source

Are antibiotics naturally antibiotics?

Journal of Industrial Microbiology & Biotechnology, 2006
Antibiotics have been used for more than 50 years and are the cornerstone of infectious disease treatment; in addition, these low-molecular-weight bioactive compounds have been applied to many other therapeutic purposes. However, there is almost no information on the evolutionary biology or ecology of naturally occurring low-molecular-weight compounds.
openaire   +2 more sources

Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice research database

, 2007
Objective: To determine the extent to which antibiotics reduce the risk of serious complications after common respiratory tract infections. Design: Retrospective cohort study.
Johnson, A. M., Livermore, D. M., Hayward, A.C., Livermore, D.M., Islam, A., Petersen, I., Duckworth, G., Johnson, A.M., Peterson, I., Hayward, A. C.   +9 more
core   +1 more source

Pre-Visit Use of Non-Prescribed Antibiotics among Child Patients in China: Prevalence, Predictors, and Association with Physicians’ Prescribing of Antibiotics at Medical Visits

, 2022
Antibiotic resistance is one of the most serious global public health crises. Inappropriate use of antibiotics is an important contributor. Using a cross-sectional survey, we recruited 3056 caregivers from 21 provinces in China to complete a ...
Wang, Nan Christine, Nan Christine Wang
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Design of Novel Carboxamides of Eremomycin and Vancomycin with 4- or 3-Amino Methyl Phenyl Boric Acid and Their Investigation

Антибиотики и Химиотерапия, 2020
Amidation of the end carboxyl group of eremomycin and vancomycin by pinacolinic 4- or 3-amino methyl phenyl boron acids esters in the presence of the condensing reagent PyBOP resulted in formation of novel carboxamides of the antibiotics (IIIa-VIa ...
E. N. Bychkova, A. M. Korolev, E. N. Olsufyeva, E. P. Mirchink, E. B. Isakova   +4 more
doaj  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Prediction of Aztreonam Effectiveness Against Klebsiella pneumoniae Based on the Results of Antimicrobial Susceptibility Testing with Increased Inoculum

Антибиотики и Химиотерапия
Background. The minimum inhibitory concentration (MIC) does not predict the risk of antibacterial resistance development due to a small sample of tested bacteria.
K. N. Alieva, M. V. Golikova, D. A. Kondratieva, A. A. Kuznetsova   +3 more
doaj   +1 more source

Antibiotics Residues as Limiting Factor of Honey Quality [PDF]

, 2015
Residues of veterinary drugs represent a significant risk to the health of honey consumers. Antibiotics can get into honey by using the antibiotics for treatment and prevention of bees diseases but also through the plant nectar and pollen. In Serbia, the
Jaksic, S, Babic, J, Apic, J, Ljubojevic, D, Zekic-Stosic, M, Zivkov-Balos, M, Petrovic, J   +6 more
core  

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source