Results 101 to 110 of about 1,625,451 (291)

Trends and Racial/Ethnic Disparities in Antibiotic Prescribing Practices of Dentists in The United States [PDF]

, 2018
Objective The aim of this study was to examine trends and racial/ethnic disparities in antibiotic prescribing practices of dentists in the United States. Methods The US Medical Expenditure Panel Survey data for 1996‐2013 was analyzed.
Okunseri, Christopher, Okunseri, Elaye, Steinmetz, C. N., Szabo, Aniko, Zheng, C.   +4 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Prediction of Aztreonam Effectiveness Against Klebsiella pneumoniae Based on the Results of Antimicrobial Susceptibility Testing with Increased Inoculum

Антибиотики и Химиотерапия
Background. The minimum inhibitory concentration (MIC) does not predict the risk of antibacterial resistance development due to a small sample of tested bacteria.
K. N. Alieva, M. V. Golikova, D. A. Kondratieva, A. A. Kuznetsova   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Antimicrobial resistance profile of clinical isolates from hospitals across China: CHINET 2024 surveillance report

One Health Advances
This study aimed to monitor clinical isolate susceptibility to antimicrobial agents in healthcare facilities in 31 provinces or cities of China in 2024.
Yan Guo, Li Ding, Renru Han, Dandan Yin, Shi Wu, Yang Yang, Fu Wang, Demei Zhu, Fupin Hu, the China Antimicrobial Surveillance Network (CHINET) Study Group   +9 more
doaj   +1 more source

Diastereoselective Synthesis of Spirocyclopropanes under Mild Conditions via Formal [2 + 1] Cycloadditions Using 2,3-Dioxo-4-benzylidene-pyrrolidines

Molecules, 2017
A highly diastereoselective cyclopropanation of cyclic enones with sulfur ylides was developed under catalyst-free conditions, producing multifunctional spirocyclopropanes in generally excellent yields (up to 99% yield and >99:1 d.r.).
Yi Li, Qing-Zhu Li, Li Huang, Hong Liang, Kai-Chuan Yang, Hai-Jun Leng, Yue Liu, Xu-Dong Shen, Xiao-Jun Gou, Jun-Long Li   +9 more
doaj   +1 more source

Evaluation of uncomplicated acute respiratory tract infection management in veterans: A national utilization review. [PDF]

, 2019
BackgroundAntibiotics are overprescribed for acute respiratory tract infections (ARIs). Guidelines provide criteria to determine which patients should receive antibiotics.
ARI Management Improvement Group, Bidwell Goetz, Matthew, Bohan, Jefferson G, Burk, Muriel, Cunningham, Francesca, Jones, Makoto, Madaras-Kelly, Karl, Neuhauser, Melinda M, Pontefract, Benjamin   +8 more
core  

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Clinical characteristics and antimicrobial therapy of healthcare-associated carbapenem-non-susceptible gram-negative bacterial meningitis: a 16-year retrospective cohort study

BMC Infectious Diseases
Objective Healthcare-associated Gram-negative bacterial meningitis is a substantial clinical issue with poor outcomes, especially for neurosurgical patients.
Jiyan Xu, Xiaoling Du, Dan Li, Pei Li, Qinglan Guo, Xiaogang Xu, Fupin Hu, Minggui Wang   +7 more
doaj   +1 more source