Results 111 to 120 of about 1,248,661 (298)

The Trend of the Antibiotics Used at the Ohu University Dental Hospital in Years of 2000 to 2002 [PDF]

, 2004
P(論文)The authors investigated which antibiotics were used in the Ohu University Dental Hospital for the three years from 2000 to 2002. 1. The oral antibiotics which were used a lot were Varacillin (LAPC), Flomox (CFPN-PI), and Clarith (CAM). 2.
浜田, 節男, 8398, 8399, 8396, 8397, 長谷川, 淳子, 8390, 大野, 敬, 8391, HASHIMOTO, Minoru, KOKUBUN, Mihoko, 8394, 8395, 8392, 8393, 中葉, 利男, イワタ, キョウイチ, ナカハ, トシオ, 国分, 美保子, コクブン, ミホコ, ハシモト, ミノル, 8406, 8407, 8404, 8405, 岩田, 教一, HASEGAWA, Junko, 8387, 8388, 8385, 8386, HAMADA, Setsuo, ハマダ, セツオ, 8402, オオノ, タカシ, 8403, 8389, 8400, 8401, OHNO, Takashi, 8384, NAKAHA, Toshio, KAGEYAMA, Toshio, ハセガワ, ジュンコ, カゲヤマ, トシオ, 影山, 利夫, 橋本, 稔, IWATA, Kyoichi   +47 more
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Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

PK/PD Modeling as a Tool for Predicting Bacterial Resistance to Antibiotics: Alternative Analyses of Experimental Data

Антибиотики и Химиотерапия, 2020
Postexposure number of mutants (NM) is a conventional endpoint in bacterial resistance studies using in vitro dynamic models that simulate antibiotic pharmacokinetics.
M. V. Golikova, E. N. Strukova, Y. A. Portnoy, A. A. Firsov   +3 more
doaj  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Development and ELISA Characterization of Antibodies against the Colistin, Vancomycin, Daptomycin, and Meropenem: A Therapeutic Drug Monitoring Approach

More than 70% of bacteria are resistant to all or nearly all known antimicrobials, creating the need for the development of new types of antimicrobials or the use of ¿last-line¿ antimicrobial therapies for the treatment of multi-resistant bacteria. These
Garzon V, G.-Pinacho D, Bustos R.-H., Salvador J.-P, Marco M.-P   +4 more
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Characteristics of demand for antibiotics in primary care: an almost ideal demand system approach [PDF]

We model demand for different classes of antibiotics used for respiratory infections in outpatient care using a linear approximate almost ideal demand system approach.
Karine Moschetti, Massimo Filippini, Giuliano Masiero   +2 more
core  

Synthesis and Antibacterial Activity of ll-O-(Benzoxaborole-Aminoalkylcarbamoyl) Derivatives of Macrolide Antibiotic Azithromycin

Антибиотики и Химиотерапия, 2020
Benzoxaborole, a structure in medicinal chemistry privileged due to its desirable physicochemical and drug-like properties, was used for the synthesis of azithromycin-benzoxaborole conjugates in which benzoxaborole fragment was attached to the 11-hydroxy
S. S. Printsevskaya, A. M. Korolev, Yu. N. Luzikov, E. P. Mirchink, E. B. Isakova, A. N. Tevyashova   +5 more
doaj  

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Alternate Strategies for Managing Resistance to Antibiotics and Pesticides [PDF]

How should one manage the problem of resistance to antibiotics and pesticides? Although the salience of this question has now been recognized, the formal modeling of this question is very much in its infancy.
Peter Nijkamp, Amit Batabyal
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