Results 31 to 40 of about 18,604 (234)
Apoptosis, annexin A5 and anti-annexin A5 antibodies in the antiphospholipid syndrome [PDF]
Journal of Medical Biochemistry, 2013 It has been proposed that apoptosis is one of the mechanisms involved in the generation of antiphospholipid antibodies. The presence of antiphospholipid antibodies is the main laboratory criterion for a definite diagnosis of the antiphospholipid syndrome.
Bećarević Mirjana +2 more
doaj
Depressed serum IgM levels in SLE are restricted to defined subgroups [PDF]
, 2017 Natural IgM autoantibodies have been proposed to convey protection from autoimmune pathogenesis. Herein, we investigated the IgM responses in 396 systemic lupus erythematosus (SLE) patients, divided into subgroups based on distinct autoantibody profiles. Depressed IgM levels were more common in SLE than in matched population controls.
arxiv +1 more source
Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity [PDF]
, 2020 Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4-CXCL4) and polyanions (P) opsonize PF4-coated bacteria hereby mediating bacterial host defense. A subset of these antibodies may activate platelets after binding to PF4-heparin complexes, causing the prothrombotic adverse drug reaction heparin-induced thrombocytopenia (HIT).
arxiv +1 more source
Prevalence of antiphospholipid antibodies in post-COVID and vaccinated individuals [PDF]
Infectious Diseases and Tropical MedicineOBJECTIVE: The outbreak of COVID-19 resulted mainly in respiratory disease; however, apart from that, the infection was presented with random systemic thromboembolic events.
S. Al-Rustum +4 more
doaj +1 more source
Improving antibody language models with native pairing [PDF]
arXiv, 2023 Current antibody language models are limited by their use of unpaired antibody sequence data and the biases in publicly available antibody sequence datasets, which are skewed toward antibodies against a relatively small number of pathogens. A recently published dataset (by Jaffe, et al) of approximately 1.6 x 10^6 natively paired human antibody ...
arxiv
Journal of Immunology Research, 2014 Objectives. A review of the literature reports neonatal thrombosis and antiphospholipid antibodies cases through a retrospective study that focuses on the pathogenesis and main clinical and laboratory manifestations of this disease. Methods.
Marcus Vinicius da Costa Peixoto +2 more
doaj +1 more source
When Two are Better than One: Modeling the Mechanisms of Antibody Mixtures [PDF]
, 2019 It is difficult to predict how antibodies will behave when mixed together, even after each has been independently characterized. Here, we present a statistical mechanical model for the activity of antibody mixtures that accounts for whether pairs of antibodies bind to distinct or overlapping epitopes.
arxiv +1 more source
AntiBARTy Diffusion for Property Guided Antibody Design [PDF]
arXiv, 2023 Over the past decade, antibodies have steadily grown in therapeutic importance thanks to their high specificity and low risk of adverse effects compared to other drug modalities. While traditional antibody discovery is primarily wet lab driven, the rapid improvement of ML-based generative modeling has made in-silico approaches an increasingly viable ...
arxiv
Archives of Pathology & Laboratory Medicine, 2002 Abstract Objective.—To review the role of lupus anticoagulants in the pathogenesis of both venous and arterial thromboembolic events, as well as in recurrent spontaneous abortions. The pathophysiology of lupus anticoagulants and associated antiphospholipid antibodies (eg, anticardiolipin antibodies) is also discussed. Data
openaire +3 more sources
Journal of Immunology Research, 2022 Background. The detection of antiphospholipid antibodies (aPL) is of interest because of their importance in the pathogenesis of arterial or venous thrombosis. They could be a “second hit” of an inflammatory event such as infection.
Amal Abouda +8 more
doaj +1 more source