The Significance of Anti-Beta-2-Glycoprotein I Antibodies in Antiphospholipid Syndrome [PDF]
Antibodies, 2016 Antiphospholipid syndrome (APS) is a thrombophilic disorder that classically presents with vascular thrombosis and/or obstetric complications. APS is associated with antiphospholipid antibodies: a heterogeneous group of autoantibodies that are directed ...
Anna Brusch
exaly +9 more sources
Antiphospholipid Antibodies to Domain I of Beta-2-Glycoprotein I Show Different Subclass Predominance in Comparison to Antibodies to Whole Beta-2-glycoprotein I [PDF]
Frontiers in Immunology, 2018 Antiphospholipid antibodies (aPL), the serological hallmark of antiphospholipid syndrome (APS), are a heterogeneous group of autoantibodies raised against circulating blood proteins.
Thomas McDonnell +7 more
doaj +7 more sources
PEGylated Domain I of Beta-2-Glycoprotein I Inhibits Thrombosis in a Chronic Mouse Model of the Antiphospholipid Syndrome [PDF]
Frontiers in Immunology, 2022 Antiphospholipid syndrome (APS) is an autoimmune disorder in which autoantibodies cause clinical effects of vascular thrombosis and pregnancy morbidity. The only evidence-based treatments are anticoagulant medications such as warfarin and heparin.
Rohan Willis +7 more
doaj +5 more sources
Beta 2 glycoprotein I and neutrophil extracellular traps: Potential bridge between innate and adaptive immunity in anti-phospholipid syndrome [PDF]
Frontiers in Immunology, 2023 Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent vascular thrombosis and miscarriages in the absence of known causes.
Claudia Grossi +12 more
doaj +2 more sources
The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury. [PDF]
PLoS ONE, 2016 Reperfusion after a period of ischemia results in reperfusion injury (IRI) which involves activation of the inflammatory cascade. In cardiac IRI, IgM natural antibodies (NAb) play a prominent role through binding to altered neoepitopes expressed on ...
Peng Zhang +10 more
doaj +2 more sources
In vivo evidence of angiogenesis inhibition by β2-glycoprotein I subfractions in the chorioallantoic membrane of chicken embryos [PDF]
Brazilian Journal of Medical and Biological Research, 2021 The vascular network expansion and functioning are important factors affecting normal intra-uterine fetal development. This study addressed the previously reported antiangiogenic potential of beta-2-glycoprotein I (β2GPI) in vivo in the chick embryo ...
C.M. Baldavira +4 more
doaj +1 more source
International Journal of Preventive Medicine, 2023 Introduction: COVID-19 is a respiratory disease caused by infection with severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). Thrombotic complications appear to be of particular importance in patients with COVID-19.
Somayeh Haghighipour +5 more
doaj +1 more source
Pathogenesis of the obstetric antiphospholipid syndrome: the key role of beta 2 glycoprotein I
Exploration of Immunology, 2022 Antiphospholipid syndrome (APS) is defined by recurrent pregnancy morbidity and/or vascular thrombosis associated with the persistent presence of antibodies against anionic phospholipid-binding proteins. Beta 2 glycoprotein I (β2GPI) and prothrombin (PT)
Pier Luigi Meroni +2 more
doaj +1 more source
Consequences of antiphospholipid syndrome in pregnancy - A review [PDF]
Romanian Journal of Rheumatology, 2023 Background and objectives. Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies (aPL) in the blood.
Astrit M. Gash
doaj +1 more source
Biology, 2021 The use of ionic metals such as zinc (Zn2+) is providing promising results in regenerative medicine. In this study, human keratinocytes (HaCaT cells) were treated with different concentrations of zinc chloride (ZnCl2), ranging from 1 to 800 µg/mL, for 3,
Beatriz Salesa +2 more
doaj +1 more source