Anticardiolipin and anti-beta-2 glycoprotein I antibodies in patients with moderate or severe COVID-19. [PDF]
Am J Med Sci, 2023 Please cite this article as: Gisela Garcia-Arellano MD, PhD , Adrian Camacho-Ortiz MD, PhD , Ilse Andrea Moreno-Arquieta MD , Jesus Alberto Cardenas-de la Garza MD , Diana Carolina Rubio-Torres MD , Elvira Garza-Gonzalez MD , Paola Bocanegra-Ibarias MD ,
Garcia-Arellano G +7 more
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Cardiolipin interacts with beta-2-glycoprotein I and forms an open conformation-Mechanisms analyzed using hydrogen/deuterium exchange. [PDF]
Protein Sci, 2021 Beta‐2‐glycoprotein I (β2GPI) is the major antigen for the antiphospholipid antibodies in the antiphospholipid syndrome. The exposed epitope in domain I of β2GPI can be recognized by the anti‐β2GPI antibody.
Tang KT, Wu TY, Chen HH, Lin CC, Hsu YH.
europepmc +2 more sources
News and meta-analysis regarding anti-Beta 2 glycoprotein I antibodies and their determination
Clinical Immunology, 2019 International audienceRecent advances allow us to propose antibodies targeting beta-2-glycoprotein I (β2-GPI) as the most specific antibodies associated with anti-phospholipid syndrome (APS). Therefore, there is now a crucial need for powerful biological
Nafai, Salma +2 more
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Autoantibodies to domain 1 of beta 2 glycoprotein I determined using a novel chemiluminescence immunoassay demonstrate association with thrombosis in patients with antiphospholipid syndrome [PDF]
Lupus, 2016 Michael Mahler +2 more
exaly +3 more sources
Beyond antibodies: Beta-2 glycoprotein I as the unsung guardian of pregnancy. [PDF]
PLoS ONEThe physiological function of beta 2 glycoprotein I (β2GPI) itself is not well understood, other than that it is a primary antigen to anti-phospholipid antibodies in the autoimmune disease antiphospholipid syndrome.
Kazunobu Yagi +6 more
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Complete nucleotide and deduced amino acid sequence of human beta 2-glycoprotein I [PDF]
Biochemical Journal, 1991 The nucleotide and complete amino acid sequence for the human ß2-glycoprotein I (ß,I) was derived by sequencing the cDNA clone pB2I- 1. In addition to the 326 amino acid residues of the mature protein this clone codes for a putative leader peptide and ...
Estaller, C. +14 more
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The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury. [PDF]
PLoS ONE, 2016 Reperfusion after a period of ischemia results in reperfusion injury (IRI) which involves activation of the inflammatory cascade. In cardiac IRI, IgM natural antibodies (NAb) play a prominent role through binding to altered neoepitopes expressed on ...
Peng Zhang +10 more
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Pathogenesis of the obstetric antiphospholipid syndrome: the key role of beta 2 glycoprotein I [PDF]
Exploration of Immunology, 2022 Antiphospholipid syndrome (APS) is defined by recurrent pregnancy morbidity and/or vascular thrombosis associated with the persistent presence of antibodies against anionic phospholipid-binding proteins. Beta 2 glycoprotein I (β2GPI) and prothrombin (PT)
Pier Luigi Meroni +2 more
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Anticardiolipin and anti-beta-2-glycoprotein I antibodies
Autoimmunity, 2005 The anticardiolipin (aCL) antibody test was first established in 1983, using cardiolipin (negatively charged phospholipid) as an antigen in a solid-phase immunoassAy. It was first applied to the study of systemic lupus erythematosus patients, and was found associated with thromboses and recurrent pregnancy losses.
Ibrahim Marai +2 more
exaly +4 more sources
Interference of lupus anticoagulant causing antiprothrombin and anti–beta-2-glycoprotein I antibodies on international normalized ratio measurements: comparative analysis of international normalized ratio methods [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Life-long vitamin K antagonist (VKA) therapy is recommended as a standard of care in antiphospholipid syndrome (APS) patients with thrombosis.
Rachel Gehlen +7 more
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