Orthobunyavirus ultrastructure and the curious tripodal glycoprotein spike [PDF]
The genus <i>Orthobunyavirus</i> within the family <i>Bunyaviridae</i> constitutes an expanding group of emerging viruses, which threaten human and animal health.
McLees, A. +42 more
core +1 more source
Prevalence of beta 2-glycoprotein I antibody in systemic lupus erythematosus patients with beta 2-glycoprotein I dependent antiphospholipid antibodies. [PDF]
To investigate whether beta 2-glycoprotein I antibody (aGPI) exists in sera that are positive for antiphospholipid antibodies (aPL).Thirty six patients with systemic lupus erythematosus (SLE) and 20 healthy volunteers were recruited. GPI independent and dependent aPL (anticardiolipin (aCL), antiphosphatidylserine, antiphosphatidylinositol ...
J, Matsuda +4 more
openaire +2 more sources
Immune responses against domain I of beta 2-glycoprotein I are driven by conformational changes: Domain I of beta 2-glycoprotein I harbors a cryptic immunogenic epitope [PDF]
Objective The presence of autoantibodies against a cryptic epitope in domain I of beta 2-glycoprotein I (beta 2GPI) is strongly associated with thrombotic events in patients with the antiphospholipid syndrome. We hypothesized that a conformational change
Gebbink, Martijn F. +13 more
core +1 more source
Antiphospholipid Antibodies and Antiphospholipid Syndrome During Pregnancy: Diagnostic Concepts
Antiphospholipid syndrome comprises of a wide spectrum of clinical and obstetric manifestations linked to the presence of antiphospholipid antibodies. APS was described in the context of lupus and later as an isolated syndrome or primary APS.
Roger A Levy +3 more
doaj +1 more source
Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. [PDF]
As a resident of early endosomal phagosomes, Mycobacterium tuberculosis is connected to the iron uptake system of the host macrophage. beta-2-microglobulin (beta2m) knockout (KO) mice are more susceptible to tuberculosis than wild-type mice, which is ...
Friedrich Priem +11 more
core +1 more source
Structural analysis of the adenovirus type 2 E3/19K protein using mutagenesis and a panel of conformation-sensitive monoclonal antibodies [PDF]
The E3/19K protein of human adenovirus type 2 (Ad2) was the first viral protein shown to interfere with antigen presentation. This 25 kDa transmembrane glycoprotein binds to major histocompatibility complex (MHC) class I molecules in the endoplasmic ...
Menz, Beatrice +9 more
core +1 more source
Sequence alignment of the Bugula neritina putative mature glycoprotein hormone beta 5 with homologs. [PDF]
CgGHB5: (EKC24490.1) glycoprotein hormone beta 5 Crassostrea gigas; TcGHB5: (EFA10760.1glycoprotein hormone beta 5) Tribolium castaneum; TnGHB5: (KRZ59516.1) glycoprotein hormone beta 5 Trichinella nativa; BmGHB5: (NP_001124380.1) glycoprotein hormone ...
Yue Him Wong (176531) +4 more
core +1 more source
beta(2)-Glycoprotein I: a novel component of innate immunity [PDF]
Sepsis is a systemic host response to invasive infection by bacteria. Despite treatment with antibiotics, current mortality rates are in the range of 20%-25%, which makes sepsis the most important cause of death in intensive care.
Stephanie D. D. C. Monk +25 more
core +1 more source
Structure-function relationships for the interleukin 2 receptor system
Receptors for interleukin 2 (IL-2) esit in at least three forms which differ in their subunit compositio, their affinity for ligand and their ability to mediate a cellular reponse.
Richard J. Robb
doaj +1 more source
Studies on specific interaction of beta-2-glycoprotein I with HBsAg
To observe the binding activity of beta-2-glycoprotein I(beta(2)GPI) to hepatitis B surface antigen (HBsAg) and the possible roles of beta(2)GPI in hepatitis B virus (HBV) infection.The rationale of ELISA methods and ELISA-based research method and ligand-blotting technique were used to detect the specific interaction of beta(2)GPI with HBsAg.With the ...
Pu-Jun, Gao +6 more
openaire +2 more sources

