Results 51 to 60 of about 42,428,678 (264)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Comparative Binding Ability of Human Monoclonal Antibodies against Omicron Variants of SARS-CoV-2: An In Silico Investigation

Antibodies, 2023
Mutation(s) in the spike protein is the major characteristic trait of newly emerged SARS-CoV-2 variants such as Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Delta-plus.
Nabarun Chandra Das, Pritha Chakraborty, Jagadeesh Bayry, Suprabhat Mukherjee   +3 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Immune responses against domain I of beta 2-glycoprotein I are driven by conformational changes: Domain I of beta 2-glycoprotein I harbors a cryptic immunogenic epitope

, 2011
Objective The presence of autoantibodies against a cryptic epitope in domain I of beta 2-glycoprotein I (beta 2GPI) is strongly associated with thrombotic events in patients with the antiphospholipid syndrome. We hypothesized that a conformational change
Gebbink, Martijn F., de Laat, Bas, Urbanus, Rolf T., Bas de Laat, Berdien Siregar, Martijn F. Gebbink, Philip G. de Groot, Coen Maas, de Groot, Philip G., Maas, Coen, Miranda van Berkel, Rolf T. Urbanus, Siregar, Berdien, van Berkel, Miranda   +13 more
core   +1 more source

Antiphospholipid Syndrome and Kidney Involvement: New Insights

Antibodies, 2016
Antiphospholipid syndrome is an autoimmune disorder characterized by vascular thromboses and pregnancy morbidity associated with antiphospholipid antibodies: lupus anticoagulant, IgG or IgM anticardiolipin or anti-beta 2-glycoprotein I. The kidney is one
José A. Martínez-Flores, Manuel Serrano, Jose M. Morales, Antonio Serrano   +3 more
doaj   +1 more source

Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif

BMC Genomic Data, 2023
Background The key evolutionary step leading to the pandemic virus was the acquisition of the PRRA furin cleavage motif at the spike glycoprotein S1/S2 junction by a progenitor of SARS-CoV-2.
Antonio R. Romeu
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter [PDF]

, 2010
The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer cells can switch their response to TGF-beta and use this cytokine as a potent oncogenic factor;
Hiller, L, Monteverde, M, Louise Hiller, Shah, Reshma, Kalna, G., Karin A. Oien, Jonathan A. Cooper, Maurer, M.E., O'Brien, Darren I, Jelena Mann, Oien, KA, Frame, MC, Frame, Margaret C., David C. K. Chu, Crook, T., Chu, David C K, Lo Nigro, Cristiana, Lattanzio, L., Orange, Clare, Spender, Lindsay C., Chu, D.C.K., Thurlow, JK, Thurlow, Johanna K., Shah, R, Linda J. Nicholson, Syed, Nelofer, Harris, Adrian L, Orange, Cl., O'Brien, Darren I., Maurer, Meghan E., Shah, R., Nicholson, LJ, Hiller, Louise, Cooper, J.A., Inman, GJ, Monteverde, M., O'Brien, DI, West, CM, Mann, Jelena, Inman, Gareth J., Harris, AL., Syed, N, Cristiana Lo Nigro, Buffa, FM, Darren I. O’Brien, West, CML, Gasco, Milena, Smith, P, Crook, Tim, Monteverde, Martino, Meghan E. Maurer, Buffa, Francesca M., Kalna, Gabriela, O Brien, DI, Patridge, Max, Hannigan, A., Patridge, M., Paul Smith, Francesca M. Buffa, Cooper, Jonathan A, Mann, J, Oien, Karin A, Crook, T, Spender, Lindsay C.; id_orcid, Reshma Shah, Smith, Paul J., Lattanzio, L, Orange, C, Catharine M. L. West, Kalna, G, Cooper, JA, Max Patridge, Smith, Paul, Johanna K. Thurlow, Margaret C. Frame, Nicholson, Linda J., O'Brien, D.I., Spender, LC, and Gareth J. Inman, Buffa, Francesca M, O'Brien, Darren I., West, Catharine M L, Herrera, Blanca, Gasco, M., Adèle Hannigan, Smith, P., Frame, MC., Milena Gasco, Lo Nigro, C., Inman, Gareth J, Herrera, B, Oien, K.A., Frame, Margaret C, Laura Lattanzio, Gabriela Kalna, West, Catharine M. L., Nicholson, Linda J, Tim Crook, West, C.M.L., Nelofer Syed, Chu, DCK, Blanca Herrera, West, Catharine M L; id_orcid, Hannigan, Adèle, Thurlow, Johanna K, Chu, DC, Mann, J., Spender, Lindsay C, Gasco, M, Clare Orange, Martino Monteverde, Patridge, M, Buffa, F.M., Maurer, Meghan E, David C.K. Chu, Chu, David C. K., Nicholson, L.J., Harris, AL, Spender, L.C., Lindsay C. Spender, Catharine M.L. West, Herrera, B., Hannigan, A, Maurer, ME, Cooper, Jonathan A., Oien, Karin A., Lo Nigro, C, Adrian L. Harris, Inman, G.J., Gareth J. Inman, Harris, Adrian L., Thurlow, J.K., Syed, N., Lattanzio, Laura   +133 more
core   +1 more source