Results 171 to 180 of about 387,972 (242)

A multivalent capsule vaccine protects against Klebsiella pneumoniae bloodstream infections in healthy and immunocompromised mice. [PDF]

NPJ Vaccines
Wantuch PL, Robinson LS, Knoot CJ, Darwech I, Matsuguma AM, Vinogradov E, Scott NE, Harding CM, Rosen DA.   +8 more
europepmc   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Salmonella typhimurium co-expressing cytolysin A and hyaluronidase suppresses tumor growth and metastasis. [PDF]

Cell Death Discov
Nguyen KV, Nguyen DH, Ngo HT, You SH, Kim SY, Hong Y, Min JJ.   +6 more
europepmc   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Antibodies to Periodontal Bacteria Are Associated with Systemic Lupus Erythematosus and Autoantibody Positivity. [PDF]

Int J Mol Sci
Massarenti L, Leffers HCB, Brodersen T, Hansen PR, Damgaard C, Pedersen OB, Jacobsen S, Nielsen CH.   +7 more
europepmc   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

Contribution of the different Neisseria gonorrhoeae lipooligosaccharide structural variants to functional responses elicited by GMMA outer membrane vesicles. [PDF]

NPJ Vaccines
Cuffaro R, Buffi G, Romagnoli G, Giuliani M, Proietti D, Zambelli M, Spinsanti M, Manetti AGO, Fabbrini M, Savino S, Giordano G, Delany I, Bartolini E, Ram S, Romano MR, Margarit I, Carboni F.   +16 more
europepmc   +1 more source

Expandable Nanocomposite Shape‐Memory Hemostat for the Treatment of Noncompressible Hemorrhage

Advanced Science, EarlyView.
A nanocomposite‐coated shape memory foam rapidly expands, accelerates clotting, and reduces blood loss in vivo. Its fast volumetric expansion and strong procoagulant activity make it a promising hemostat for treating deep, noncompressible hemorrhage.
Saptarshi Biswas, Sarah E. Miller, Shounak Roy, Jeevika Thazhaiselvam, Samantha Foster, Manivannan Sivaperuman Kalairaj, Sasha M. George, Yava Jones‐Hall, Staci J. Horn, Fred J. Clubb, Taylor H. Ware, Duncan J. Maitland, Akhilesh K. Gaharwar   +12 more
wiley   +1 more source

Taming Superbugs: Current Progress and Challenges in Combating ESKAPE Pathogens. [PDF]

Pathogens
Hetta HF, Khalaf FR, Kotb AA, Alatawi MN, Albalawi AS, Alharbi AA, Aljohani MK, Aljohani SS, Alatawi MS, Abd Ellah NH, Battah B, Donadu MG, Mazzarello V.   +12 more
europepmc   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source