Results 11 to 20 of about 417,575 (218)

Investigation of Cas9 antibodies in the human eye

Nature Communications, 2022
Pre-existing antibodies against Cas9 proteins represent a potential issue for gene therapies, including those targeting the eye. Here the authors assess the presence of intraocular antibodies, and show that Cas9 antibodies were prevalent in human serum ...
Marcus A. Toral, Carsten T. Charlesworth, Benjamin Ng, Teja Chemudupati, Shota Homma, Hiromitsu Nakauchi, Alexander G. Bassuk, Matthew H. Porteus, Vinit B. Mahajan   +8 more
doaj   +1 more source

A Possible Link between Infection with Burkholderia Bacteria and Systemic Lupus Erythematosus Based on Epitope Mimicry

Clinical and Developmental Immunology, 2008
We previously demonstrated that purified polyclonal and monoclonal anti-dsDNA antibodies bind a 15-mer peptide ASPVTARVLWKASHV in ELISA and Dot blot. This 15-mer peptide partial sequence ARVLWKASH shares similarity with burkholderia bacterial cytochrome ...
Wei Zhang, Morris Reichlin
doaj   +1 more source

Presence of anti-microbial antibodies in liver cirrhosis--a tell-tale sign of compromised immunity? [PDF]

PLoS ONE, 2010
BACKGROUND: Bacterial translocation plays important role in the complications of liver cirrhosis. Antibody formation against various microbial antigens is common in Crohn's disease and considered to be caused by sustained exposure to gut microflora ...
Maria Papp, Gary L Norman, Zsuzsanna Vitalis, Istvan Tornai, Istvan Altorjay, Ildiko Foldi, Miklos Udvardy, Zakera Shums, Tamas Dinya, Peter Orosz, Bela Lombay, Gabriella Par, Alajos Par, Gabor Veres, Timea Csak, Janos Osztovits, Ferenc Szalay, Peter Laszlo Lakatos   +17 more
doaj   +1 more source

Immunoglobulin for Treating Bacterial Infections: One More Mechanism of Action

Antibodies, 2019
The mechanisms underlying the effects of immunoglobulins on bacterial infections are thought to involve bacterial cell lysis via complement activation, phagocytosis via bacterial opsonization, toxin neutralization, and antibody-dependent cell-mediated ...
Teiji Sawa, Mao Kinoshita, Keita Inoue, Junya Ohara, Kiyoshi Moriyama   +4 more
doaj   +1 more source

Predicted serotype-specific effectiveness of pneumococcal conjugate vaccines V114 and PCV20 against invasive pneumococcal disease in children

Expert Review of Vaccines
Background Next-generation, higher-valency pneumococcal conjugate vaccines (PCVs), 15-valent PCV V114 and 20-valent PCV (PCV20), have been assessed by comparing their immune responses across serotypes shared with the 13-valent PCV (PCV13).
Josiah Ryman, Jeffrey R. Sachs, Ka Lai Yee, Natalie Banniettis, Jessica Weaver, Thomas Weiss   +5 more
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The Immunogenicity of Glutaraldehyde Inactivated PTx Is Determined by the Quantity of Neutralizing Epitopes

Vaccines
Background/Objectives: Chemically or genetically detoxified pertussis toxin (PTx) is a crucial antigen component of the acellular pertussis vaccine. Chemical detoxification using glutaraldehyde generally causes significant structural changes to the toxin.
Xi Wang, Xinyue Cui, Chongyang Wu, Ke Tao, Shuyuan Pan, Wenming Wei   +5 more
doaj   +1 more source

Vaccine-induced antibodies can limit Salmonella infection in the absence of complement or macrophages

mBio
Antibodies against Salmonella Typhimurium (STm) can provide protection against infection. Understanding how antibodies, complement, and leukocytes interact is essential and can help advance vaccine development.
Marisol Perez-Toledo, Kubra Aksu-Istil, Edith Marcial-Juarez, Ruby R. Persaud, Areej Alshayea, Sian E. Jossi, Agostina Carestia, Fien von Meijenfeld, Marina Botto, Leo C. James, Bas Surewaard, Zaheer Afzal, Adrian M. Shields, William G. Horsnell, Constantino Lopez-Macias, Ian R. Henderson, Craig N. Jenne, Adam F. Cunningham   +17 more
doaj   +1 more source

Artificial surface labelling of Escherichia coli with StrepTagII antigen to study how monoclonal antibodies drive complement-mediated killing

Scientific Reports, 2023
Antibodies play a key role in the immune defence against Gram-negative bacteria. After binding to bacterial surface antigens, IgG and IgM can activate the complement system and trigger formation of lytic membrane attack complex (MAC) pores.
Remy M. Muts, Maurits A. den Boer, Bart W. Bardoel, Piet C. Aerts, Carla J. C. de Haas, Albert J. R. Heck, Suzan H. M. Rooijakkers, Dani A. C. Heesterbeek   +7 more
doaj   +1 more source

IgY antibodies: The promising potential to overcome antibiotic resistance

Frontiers in Immunology, 2023
Antibiotic resistant bacteria are a growing threat to global health security. Whilst the emergence of antimicrobial resistance (AMR) is a natural phenomenon, it is also driven by antibiotic exposure in health care, agriculture, and the environment ...
Sherif A. El-Kafrawy, Sherif A. El-Kafrawy, Sherif A. El-Kafrawy, Aymn T. Abbas, Aymn T. Abbas, Aymn T. Abbas, Christopher Oelkrug, Marwa Tahoon, Sameera Ezzat, Sameera Ezzat, Alimuddin Zumla, Alimuddin Zumla, Alimuddin Zumla, Esam I. Azhar, Esam I. Azhar   +14 more
doaj   +1 more source

Human antibody targeting Vibrio cholerae O1 O-specific polysaccharide induces an amotile hypovirulent bacterial phenotype: mechanism of protection against cholera

mBio
Antibodies targeting the O-specific polysaccharide (OSP) of Vibrio cholerae O1 are crucial determinants of protection against cholera. These antibodies agglutinate bacteria and, even in sub-agglutinating conditions, inhibit V. cholerae motility.
Smriti Verma, Murat Cetinbas, Meagan Kelly, Stefania Senger, Christina S. Faherty, Jeshina Janardhanan, Chanchal R. Wagh, Taufiqur Rahman Bhuiyan, Fahima Chowdhury, Ashraful Islam Khan, Aklima Akter, Richelle C. Charles, Jason B. Harris, Stephen B. Calderwood, Jens Wrammert, Matthew K. Waldor, Merrill Asp, Jung-Shen Benny Tai, Jing Yan, Peng Xu, Pavol Kováč, Ruslan I. Sadreyev, Firdausi Qadri, Edward T. Ryan   +23 more
doaj   +1 more source