Results 11 to 20 of about 402,506 (263)

Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease

npj Vaccines, 2021
Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components of the innate immune response. We aimed to determine if naturally occurring or vaccine-induced
Lionel K. K. Tan, Mark Reglinski, Daryl Teo, Nada Reza, Lucy E. M. Lamb, Vaitehi Nageshwaran, Claire E. Turner, Mats Wikstrom, Inga-Maria Frick, Lars Bjorck, Shiranee Sriskandan   +10 more
doaj   +1 more source

A Novel Autoantibody Induced by Bacterial Biofilm Conserved Components Aggravates Lupus Nephritis

Frontiers in Immunology, 2021
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiple autoantibody production and often affects the kidneys, known as lupus nephritis. However, the mechanism underlying lupus nephritis development is unclear.
Wenyan Fu, Wenyan Fu, Yu Liu, Yu Liu, Fangjie Liu, Fangjie Liu, Chenghua Liu, Chenghua Liu, Jingjing Li, Jiali Niu, Peng Han, Dan Xu, Jiaojiao Hou, Yuanfang Ma, Jiannan Feng, Jiannan Feng, Zhanguo Li, Rong Mu, Guang Yang, Guang Yang   +19 more
doaj   +1 more source

Investigation of Cas9 antibodies in the human eye

Nature Communications, 2022
Pre-existing antibodies against Cas9 proteins represent a potential issue for gene therapies, including those targeting the eye. Here the authors assess the presence of intraocular antibodies, and show that Cas9 antibodies were prevalent in human serum ...
Marcus A. Toral, Carsten T. Charlesworth, Benjamin Ng, Teja Chemudupati, Shota Homma, Hiromitsu Nakauchi, Alexander G. Bassuk, Matthew H. Porteus, Vinit B. Mahajan   +8 more
doaj   +1 more source

Therapeutic effect of polyclonal lipoprotein SA2275 antibodies on Staphylococcus aureus-induced brain abscess in mice

Di-san junyi daxue xuebao, 2020
Objective To investigate the ability of specific polyclonal antibodies against Staphylococcus aureus (S. aureus) lipoprotein SA2275 to penetrate the blood-brain barrier for inhibiting the formation of S. aureus-induced brain abscess in mice.
ZHENG Ying, ZHENG Ying, YANG Yi, PENG Huagang   +3 more
doaj   +1 more source

Altered functionality of anti-bacterial antibodies in patients with chronic hepatitis C virus infection. [PDF]

PLoS ONE, 2013
Using comparative glycoproteomics, we have previously identified a glycoprotein that is altered in both amount and glycosylation as a function of liver cirrhosis.
Anne Lamontagne, Ronald E Long, Mary Ann Comunale, Julie Hafner, Lucy Rodemich-Betesh, Mengjun Wang, Jorge Marrero, Adrian M Di Bisceglie, Timothy Block, Anand Mehta   +9 more
doaj   +1 more source

Presence of anti-microbial antibodies in liver cirrhosis--a tell-tale sign of compromised immunity? [PDF]

PLoS ONE, 2010
BACKGROUND: Bacterial translocation plays important role in the complications of liver cirrhosis. Antibody formation against various microbial antigens is common in Crohn's disease and considered to be caused by sustained exposure to gut microflora ...
Maria Papp, Gary L Norman, Zsuzsanna Vitalis, Istvan Tornai, Istvan Altorjay, Ildiko Foldi, Miklos Udvardy, Zakera Shums, Tamas Dinya, Peter Orosz, Bela Lombay, Gabriella Par, Alajos Par, Gabor Veres, Timea Csak, Janos Osztovits, Ferenc Szalay, Peter Laszlo Lakatos   +17 more
doaj   +1 more source

A Possible Link between Infection with Burkholderia Bacteria and Systemic Lupus Erythematosus Based on Epitope Mimicry

Clinical and Developmental Immunology, 2008
We previously demonstrated that purified polyclonal and monoclonal anti-dsDNA antibodies bind a 15-mer peptide ASPVTARVLWKASHV in ELISA and Dot blot. This 15-mer peptide partial sequence ARVLWKASH shares similarity with burkholderia bacterial cytochrome ...
Wei Zhang, Morris Reichlin
doaj   +1 more source

Immunoglobulin for Treating Bacterial Infections: One More Mechanism of Action

Antibodies, 2019
The mechanisms underlying the effects of immunoglobulins on bacterial infections are thought to involve bacterial cell lysis via complement activation, phagocytosis via bacterial opsonization, toxin neutralization, and antibody-dependent cell-mediated ...
Teiji Sawa, Mao Kinoshita, Keita Inoue, Junya Ohara, Kiyoshi Moriyama   +4 more
doaj   +1 more source

Predicted serotype-specific effectiveness of pneumococcal conjugate vaccines V114 and PCV20 against invasive pneumococcal disease in children

Expert Review of Vaccines
Background Next-generation, higher-valency pneumococcal conjugate vaccines (PCVs), 15-valent PCV V114 and 20-valent PCV (PCV20), have been assessed by comparing their immune responses across serotypes shared with the 13-valent PCV (PCV13).
Josiah Ryman, Jeffrey R. Sachs, Ka Lai Yee, Natalie Banniettis, Jessica Weaver, Thomas Weiss   +5 more
doaj   +1 more source

IgY antibodies: The promising potential to overcome antibiotic resistance

Frontiers in Immunology, 2023
Antibiotic resistant bacteria are a growing threat to global health security. Whilst the emergence of antimicrobial resistance (AMR) is a natural phenomenon, it is also driven by antibiotic exposure in health care, agriculture, and the environment ...
Sherif A. El-Kafrawy, Sherif A. El-Kafrawy, Sherif A. El-Kafrawy, Aymn T. Abbas, Aymn T. Abbas, Aymn T. Abbas, Christopher Oelkrug, Marwa Tahoon, Sameera Ezzat, Sameera Ezzat, Alimuddin Zumla, Alimuddin Zumla, Alimuddin Zumla, Esam I. Azhar, Esam I. Azhar   +14 more
doaj   +1 more source