Results 261 to 270 of about 1,461,609 (326)

Screening of Theaflavins That Inhibit Proliferation of Nasopharyngeal Carcinoma Cells Through Metabolomics Approaches

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
This study investigated the effects of theaflavin‐3,3′‐digallate (TF3) markedly suppresses the proliferation, migration, invasion of nasopharyngeal carcinoma cells while promoting apoptosis in a dose‐dependent manner. Metabolomic profiling identified 584 altered metabolites, revealing key disruptions in ABC transporter activity and amino acid ...
Chunpeng Wan, Xiaomeng Hu, Puxiang Yang, Mingxi Li, Muhammad Farrukh Nisar, Zihao Zhou, Yudi Gan, Yi Cai, Zhonghua Liu   +8 more
wiley   +1 more source

A novel bispecific antibody CVL006 superior to AK112 for dual targeting of PD-L1 and VEGF in cancer therapy. [PDF]

Antib Ther
Wang C, Huang H, Song Z, Li Z, Huang J, Cao L, Wu Z, Pan J, Chen X, Shen X.   +9 more
europepmc   +1 more source

Harnessing the immunotherapeutic potentials of gamma delta T cells against hematological malignancies

HemaSphere, Volume 9, Issue 8, August 2025.
Abstract Gamma delta (γδ) T cells, which constitute about 5%–10% of peripheral blood lymphocytes, play key roles in tumor immunosurveillance and are often enriched within epithelial tissues. They are unique in their Major Histocompatibility Complex‐independent antigen recognition via the γδ T‐cell receptor (TCR) as well as via innate receptors, making ...
Charles Agbuduwe, John Maher, John Anderson   +2 more
wiley   +1 more source

Reduced CD20 expression yields inferior survival in patients with B-cell lymphoma treated with CD20×CD3 antibodies. [PDF]

Blood Neoplasia
Kyvsgaard ER, Grantzau TL, Sørensen MD, Møller MB, Dissing Sjø L, Grauslund M, Trab T, Melchior LC, Andersen LS, Riley C, Niemann CU, Haaber J, Larsen TS, Roost Clausen M, Grønbæk K, Hutchings M, Husby S.   +16 more
europepmc   +1 more source

Inflammatory signaling in the pathogenesis of acute myeloid leukemia

HemaSphere, Volume 9, Issue 8, August 2025.
ABSTRACT Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of hematopoietic stem and progenitor cells and the most common malignant myeloid disorder in adults. Extensive research has elucidated the broad spectrum of biological mechanisms contributing to the development of AML and specifically characterized a variety of genetic alterations
Artemis Margrith Baumann, Jana Maria Ellegast   +1 more
wiley   +1 more source

Bioorthogonal Reaction of o-Quinone with Furan-2(3H)-One for Site-Selective Tyrosine Conjugation and Construction of Bispecific Antibody Complexes. [PDF]

Adv Sci (Weinh)
Chen H, Xu Z, Bao Y, Shiri F, Yuan D, Hu Y, Li B, Zeng B, Li X, Kong H, Wang Z, Lau WC, Lin Z, Xia J.   +13 more
europepmc   +1 more source

Characteristics, Treatment Patterns, and Outcomes of Patients with Multiple Myeloma, Including Those Who are Triple‐Class Exposed: A Retrospective Cohort Study in England Using National Cancer Registry Data

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT Introduction Multiple myeloma (MM) prognosis worsens once patients become triple‐class exposed (TCE) to at least one treatment in each class: immunomodulators, proteasome inhibitors, and anti‐CD38 monoclonal antibodies. Methods We conducted a retrospective study using the Cancer Analysis System database to assess characteristics, treatment ...
Carmen Tsang, Kellyn Arnold, Charles Duffield, Stavros Oikonomou, Thomas Price, Tarana Mehdikhanova, Samuel Wood, Mamta Garg   +7 more
wiley   +1 more source

T‐Cell Receptor Repertoires Show Dynamic Variation Between Diagnosis and Relapse of Diffuse Large B‐Cell Lymphoma

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT Background Tumour infiltrating lymphocyte (TIL) T‐cell receptor (TCR) repertoire is prognostic in newly diagnosed diffuse large B‐cell lymphoma (DLBCL), but evolution has not been evaluated at relapse. Methods We examined the TCR repertoire in nine paired DLBCL samples from diagnosis and relapse. Results We noted considerable differences, with
Joel Wight, Tom Witkowski, Colm Keane, Eliza A. Hawkes   +3 more
wiley   +1 more source

Targeted Degradation of Class 1 HDACs With PROTACs is Highly Effective at Inducing DLBCL Cell Death

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT Despite the good options for the management of Diffuse large B‐cell lymphoma (DLBCL), a significant percentage of patients either do not respond to current treatments or relapse after a short time. Thus, a wider palette of targeted therapeutic strategies is needed.
Abdullah Alraddadi, Joshua P. Smalley, Wael Alzahrani, Anes Saleh, Fares Al‐Mansour, Buwei He, Thong H. Cao, Sandrine Jayne, Martin Dyer, James T. Hodgkinson, Donald J. L. Jones, Shaun M. Cowley, Salvador Macip   +12 more
wiley   +1 more source

Insights from the bottom-up development of LGR5-targeting immunotherapeutics. [PDF]

Immunother Adv
Mueller N, de la Roche MA, de la Roche M.   +2 more
europepmc   +1 more source