Results 251 to 260 of about 405,156 (331)

IgE clonality and aggregation of insulin affect IgE-mediated activation of sensitized basophils. [PDF]

J Allergy Clin Immunol Glob
Christoffersen S, Baumann K, Millner AH, Toft-Hansen H, Johansson E, Thorlaksen C, Skov PS.   +6 more
europepmc   +1 more source

Immunoglobulin G Fc engineering for localized therapy: Eliminating neonatal Fc receptor interactions and ensuring purification using protein A

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Monoclonal antibodies (mAbs) and bispecific antibodies (bsAbs) have transformed therapeutic strategies for various diseases. However, administering them can lead to unwanted adverse effects and insufficient delivery to local disease sites.
Akifumi Kato, Asami Toshima, Gennosuke Takekawa, Hikaru Miyagi, Ai Kubota, Sayaka Hori, Yasunori Uemura, Rinpei Niwa   +7 more
wiley   +1 more source

A fluorescent STING ligand sensor for high-throughput screening of compounds that can enhance tumor immunotherapy. [PDF]

Cell Rep Methods
Sun P, Wang B, Liu C, Wang Z, Liu Y, Qiao YB, Li X.   +6 more
europepmc   +1 more source

Should We Advance Our Understanding of Immunoglobulin E in Viral Immunity?

Immunology, Volume 176, Issue 3, Page 312-321, November 2025.
Immunoglobulin E has been extensively studied in allergies and parasitic diseases. Antigen‐specific IgE has been identified as part of the humoral response to viruses. This revision speculates on possible functionalities for IgE, such as neutralisation, cytotoxicity and immunopathology of viral diseases, and provide insights about gaps to fill in ...
Amanda Izeli Portilho, Valéria Oliveira Silva, Luis Fernando de Macedo Brigido, Elizabeth De Gaspari   +3 more
wiley   +1 more source

Pharmacokinetics, Pharmacodynamics, and Immunogenicity of CM313 in Healthy Participants: An Open-Label/Double-Blind, Randomized, Placebo-Controlled Phase 1 Trial. [PDF]

Clin Transl Sci
Yu S, Wu J, Zhao J, He J, Yan H, Zhang X, Yang Y, Song H, Hou Q, Guo B, Qiu Y, Chen B, Xue Y, Zhang J.   +13 more
europepmc   +1 more source

Solvent‐Enabled Selective Electrochemical Decarboxylative Acetoxylation of Fmoc‐Protected Peptides

ChemElectroChem, Volume 12, Issue 19, October 3, 2025.
Electrochemical decarboxylative acetoxylation of Fmoc‐protected peptides via anodic oxidation of the carboxylic acid is challenging under conventional conditions, due to the lability of the Fmoc protecting group. Using selected cosolvents which can be oxidized at higher potentials than the target carboxylic acid but lower than the protecting group, the
David M. Köpfler, Paul Hanselmann, Michaël Bersier, Clara Bovino, Ryan Littich, Simon Wagschal, Dominique M. Roberge, C. Oliver Kappe, David Cantillo   +8 more
wiley   +1 more source

An Effective Prophylactic and Therapeutic Protection Against Botulinum Type A Intoxication in Mice and Rabbits Using a Humanized Monoclonal Antibody. [PDF]

Toxins (Basel)
Yu CH, Song YJ, Song DH, Joe HE, Kim CH, Yun H, Kim NY, Sim E, Jeong ST, Hur GH.   +9 more
europepmc   +1 more source

Mapping Drivers of Coronary Endothelial Activation and Endothelial‐to‐Mesenchymal Transition through Mimicking of Multimediator Inflammation in Kawasaki Disease Context

ACR Open Rheumatology, Volume 7, Issue 10, October 2025.
Objective Kawasaki disease (KD) is an acute systemic vasculitis predominantly affecting coronary arteries of infants and children. We recently identified leucin‐rich α‐2‐glycoprotein 1 (LRG‐1) as known transforming growth factor β1 (TGFβ1) signal‐modulating molecule, orchestrating endothelial activation and cardiac remodeling, as associated with ...
Pia Buthe, Marie Carlotta Limburg, Sabrina Fuehner, Julia Kuehn, André Jakob, Isabelle Koné‐Paut, Stéphanie Tellier, Alexandre Belot, Linda Rossi‐Semerano, Perrine Dusser‐Benesty, Isabelle Marie, Jana Merfort, Katja Masjosthusmann, Claas Hinze, Helmut Wittkowski, Dirk Foell, Christoph Kessel   +16 more
wiley   +1 more source

Reduction of extracellular vimentin in blood provides protection against SARS-CoV-2 infection. [PDF]

Virulence
Kim HM, Wang M, Zhai C, Kim S, Park J, Hong ST.   +5 more
europepmc   +1 more source

Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease

Advanced Biology, Volume 9, Issue 10, October 2025.
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang, Fujing Wang, Wei Xiong, Guangwei Shi, Junling Yuan, Yang Li, Hongyan Zhang, Yanmei Xing, Shan Jin, Kongjun Yang, Zhongliang Dai, Jichao Sun, Zhijie Li, Jianhong Wang   +13 more
wiley   +1 more source