Results 91 to 100 of about 1,727,618 (310)

Association between SARS-CoV-2 neutralizing antibodies and commercial serological assays

bioRxiv, 2020
Introduction Commercially available SARS-CoV-2 serological assays based on different viral antigens have been approved for the qualitative determination of anti-SARS-CoV-2 antibodies.
Mei San Tang, J. Case, Caroline E Franks, Rita E. Chen, N. Anderson, J. P. Henderson, M. Diamond, A. Gronowski, C. Farnsworth   +8 more
semanticscholar   +1 more source

Development of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection [PDF]

Current Opinion in HIV and AIDS, 2014
Detailed genetic and structural characterization has revealed that broadly neutralizing antibodies (bnAbs) against HIV-1 have unusually high levels of somatic hypermutation, long CDRH3 domains, and the ability to target one of four sites of vulnerability on the HIV-1 envelope (Env) glycoproteins.
Cynthia A. Derdeyn, Penny L. Moore, Lynn Morris   +2 more
openaire   +3 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Antibodies to coronaviruses are higher in older compared with younger adults and binding antibodies are more sensitive than neutralizing antibodies in identifying coronavirus‐associated illnesses

Journal of Medical Virology, 2020
Human coronaviruses (HCoV) are common causes of respiratory illnesses (RI) despite preexisting humoral immunity. Sera were obtained near the onset of RI and 3 to 4 weeks later as part of a prospective study of 200 subjects evaluated for RI from 2009 to ...
G. Gorse, M. M. Donovan, G. B. Patel
semanticscholar   +1 more source

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, EarlyView.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source

Evolution of cross-neutralizing antibody specificities to the CD4-BS and the carbohydrate cloak of the HIV Env in an HIV-1-infected subject. [PDF]

PLoS ONE, 2012
Broadly neutralizing antibodies are considered an important part of a successful HIV vaccine. A better understanding of the factors underlying their development during infection and of the epitopes they target is needed to elicit similar antibody ...
Iliyana Mikell, Leonidas Stamatatos
doaj   +1 more source

SARS-CoV-2 neutralizing antibodies; longevity, breadth, and evasion by emerging viral variants

medRxiv, 2020
The SARS-CoV-2 antibody neutralization response and its evasion by emerging viral variants are unknown. Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus-cell fusion, and infectious SARS-CoV-2 ...
F. Tea, A. Stella, A. Aggarwal, David R Darley, D. Pilli, D. Vitale, V. Merheb, Fiona X. Z. Lee, P. Cunningham, G. Walker, David A. Brown, W. Rawlinson, Sonia R Isaacs, Vennila Mathivanan, Markus Hoffman, Stefan Pöhlmann, Dominic E. Dwyer, Rebeca Rockett, V. Sintchenko, Veronica C. Hoad, D. Irving, G. Dore, Iain B. Gosbell, A. Kelleher, G. Matthews, F. Brilot, S. Turville   +26 more
semanticscholar   +1 more source

Efgartigimod Combined With Steroid Treatment for HAM/TSP: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurological disorder with limited treatment options. We report a 54‐year‐old female with decade‐long, progressive HAM/TSP, previously refractory to rituximab, who experienced worsening spastic paraparesis and neurogenic bladder dysfunction.
Jiahui Zeng, Wotu Tian, Jingran Yang, Yanping Yang, Li Cao, Xinghua Luan   +5 more
wiley   +1 more source

Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2

Signal Transduction and Targeted Therapy, 2020
The outbreaks of severe acute respiratory syndrome (SARS) and Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV and SARS-CoV-2, respectively, have posed severe threats to global public health and the economy.
F. Yu, Rong Xiang, Xiaoqian Deng, Lili Wang, Zhengsen Yu, Shijun Tian, Ruiying Liang, Yanbai Li, T. Ying, Shibo Jiang   +9 more
semanticscholar   +1 more source

Neutralizing Antibody Response and SARS Severity

Emerging Infectious Diseases, 2005
Using the Taiwan nationwide laboratory-confirmed severe acute respiratory syndrome (SARS) database, we analyzed neutralizing antibody in relation to clinical outcomes. With a linear mixed model, neutralizing antibody titer was shown to peak between week 5 and week 8 after onset and to decline thereafter, with a half-life of 6.4 weeks.
Ho, Mei-Shang, Chen, Wei-Ju, Chen, Hour-Young, Lin, Szu-Fong, Wang, Min-Chin, Di, Jiali, Lu, Yen-Ta, Liu, Ching-Lung, Chang, Shan-Chwen, Chao, Chung-Liang, King, Chwan-Chuen, Chiou, Jeng-Min, Su, Ih-Jen, Yang, Jyh-Yuan   +13 more
openaire   +5 more sources