Results 81 to 90 of about 711,003 (258)

Fig. 4e: CXCL12-neutralizing

, 2022
Fig. 4e In the co-culture experiment of RHBDD2-CKO HEK293T and U937, pre-treatment with CXCL12-neutralizing antibodies increased cleaved caspase-3-positive cells under cytarabine exposure for 48 h, which was similar to that observed when the cells were ...
Keisuke Sugita (12549460), Morito Kurata (8164626)   +1 more
core   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Biomimetic Core–Shell Liposome Nanoparticles Deplete Lipoproteins and Enhance the Purity of Extracellular Vesicles from Human Blood

Advanced Functional Materials, EarlyView.
Lipoprotein‐mimicking nanoparticles (SL‐NPs), comprising Fe3O4@SiO2 cores coated with liposomal bilayers, selectively capture lipoproteins through protein corona formation. The resulting SL‐NP‐lipoprotein complexes can be removed by low‐speed centrifugation, thereby enhancing the purity of small extracellular vesicles (sEVs) isolated from human serum ...
Man‐Di Wang, Andrew J. Perciaccante, David Inman, Bong Hwan Sung, Alissa M. Weaver, Suzanne M. Ponik, Ying Ge, Song Jin   +7 more
wiley   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Development and Validation of the Cell-based Functional Method for Neutralizing Anti-adalimumab Antibodies Detection in Human Serum

Разработка и регистрация лекарственных средств
Introduction. Adalimumab, a fully humanized monoclonal antibody, is a tumor necrosis factor (TNFα) inactivator that is used against a number of autoimmune diseases such as rheumatoid arthritis and other most common inflammatory arthropathies (ankylosing ...
M. A. Nikiforova, I. A. Valouev, A. V. Petrov, E. E. Beketov, I. E. Shokhin   +4 more
doaj   +1 more source

Nano Borophene as a Programmable 2D Scaffold for Organized DNA Assembly and Long‐Range Energy Transfer

Advanced Functional Materials, EarlyView.
Borophene is introduced as a programmable 2D bio‐interface that organizes DNA through dual boron–sulfur and nucleobase interactions. This molecular architecture enables efficient long‐range nanosurface energy transfer, establishing new design principles for functional nano–bio interfaces and amplification‐free optical biosensing.
Teresa Aditya, Pranay Saha, John M. Sansalone, Shraddha Krishnakumar, Matthew Molinaro, André J. van der Vlies, Nada Maher, Adrienne Griffiths, Zakhro Zakirova, Ketan Dighe, Narayana R. Aluru, Dipanjan Pan   +11 more
wiley   +1 more source

Rapid Quantification of SARS-CoV-2-Neutralizing Antibodies Using Propagation-Defective Vesicular Stomatitis Virus Pseudotypes. [PDF]

, 2020
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2, a new member of the genus Betacoronavirus, is a pandemic virus, which has caused numerous fatalities, particularly in the elderly and persons with underlying morbidities. At present, there
Meister, Toni Luise, Stephanie Pfaender, Gert Zimmer, Pfaender, Stephanie, Vollmer, Tanja, Steinmann, Jörg, Philip V’kovski, Todt, Daniel, Tanja Vollmer, Daniel Todt, Toni Luise Meister, Adalbert Krawczyk, Zimmer, Gert, Bastian Fischer, Eike Steinmann, Jörg Steinmann, Ferdinand Zettl, Zettl, Ferdinand, Krawczyk, Adalbert, V'kovski, Philip, Fischer, Bastian, Steinmann, Eike   +21 more
core   +2 more sources

Rotavirus 993/83, isolated from calf faeces, closely resembles an avian rotavirus [PDF]

, 1992
Polypeptides from purified virions of the calf rotavirus (RV) isolate 993/83 and those from the pigeon RV isolate PO-13 comigrated on SDS-polyacrylamide gels. Two polypeptides of 45K and 47K were detected at the position of VP6.
Eichhorn, Werner, Werner Eichhorn, Harald Briissow, Osamu Nakagomi, Nobuyuki Minamoto, Nakagomi, Osamu, Büssow, Harald, Minamoto, Nobuyuki   +7 more
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

SARS-CoV-2 Neutralizing Antibodies 2.0

Viruses
As the SARS-CoV-2 mutates, especially into those variants causing immune escape, COVID-19 continues to wreak havoc [...]
Youchun Wang
doaj   +1 more source