Results 1 to 10 of about 30,573 (156)

Cross-reactive broadly neutralizing antibodies: timing is everything [PDF]

Frontiers in Immunology, 2012
The recent surge of research into new broadly neutralizing antibodies in HIV-1 infection has recharged the field of HIV-1 vaccinology. In this review we discuss the currently known broadly neutralizing antibodies and focus on factors that may shape these
Zelda Euler, Hanneke Schuitemaker, Schuitemaker Hanneke   +2 more
exaly   +5 more sources

Broadly Neutralizing Antibodies for HIV-1 Prevention [PDF]

Frontiers in Immunology, 2021
Given the absence of an effective vaccine for protection against HIV-1 infection, passive immunization strategies that utilize potent broadly neutralizing antibodies (bnAbs) to block acquisition of HIV-1 are being rigorously pursued in the clinical ...
Stephen R. Walsh, Michael S. Seaman
doaj   +3 more sources

The expanding array of HIV broadly neutralizing antibodies [PDF]

Retrovirology, 2018
A large array of broadly neutralizing antibodies (bnAbs) against HIV have been isolated and described, particularly in the last decade. This continually expanding array of bnAbs has crucially led to the identification of novel epitopes on the HIV ...
Laura E. McCoy
doaj   +4 more sources

Delivery platforms for broadly neutralizing antibodies. [PDF]

Curr Opin HIV AIDS, 2023
Purpose of review Passive administration of broadly neutralizing antibodies (bNAbs) is being evaluated as a therapeutic approach to prevent or treat HIV infections. However, a number of challenges face the widespread implementation of passive transfer for HIV. To reduce the need of recurrent administrations of bNAbs, gene-based
Joshi LR, Gálvez NMS, Ghosh S, Weiner DB, Balazs AB.   +4 more
europepmc   +3 more sources

Defining criteria for broadly neutralizing HIV antibodies

Frontiers in Immunology
Over the course of a few years, a small percentage of individuals with HIV-1 develop broadly neutralizing antibodies (bnAbs) capable of neutralizing diverse viruses.
Elizabeth-Sharon David-Fung, Katherine A. Belobrajdic, Jennifer P. Macke, Corey R. Quackenbush, Kumkum Ganguly, Jennifer L. Mamrosh   +5 more
doaj   +3 more sources

Broadly neutralizing antibodies against influenza viruses [PDF]

Antiviral Research, 2013
Despite available antivirals and vaccines, influenza continues to be a major cause of mortality worldwide. Vaccination generally induces an effective, but strain-specific antibody response. As the virus continually evolves, new vaccines have to be administered almost annually when a novel strain becomes dominant.
Nick S Laursen, Ian A Wilson
exaly   +3 more sources

Development of broadly neutralizing antibodies against Omicron variants from existing neutralizing antibodies in clinical trials [PDF]

Virology Journal
Background The introduction of new SARS-CoV-2 Omicron strains has made it extremely difficult to create broadly neutralizing antibodies (nAbs) with assured therapeutic potential.
Yongbo Huang, Zhimin Lin, Xueyan Guo, Fangfang Zhang, Yanqun Wang, Zhaoyong Zhang, Jiantao Chen, Lu Liu, Mengzhu Zhu, Yiting Li, Meng Ni, Zixian Zhen, Zhihai Wu, Xiaomin Ling, Shuaixiang Zhou, Yin Xi, Yuheng Yu, Wenhua Liang, Jincun Zhao, Li Li, Jianxing He, Ling Sang   +21 more
doaj   +2 more sources

Broadly neutralizing antibodies in HIV-1 treatment and prevention

Therapeutic Advances in Vaccines and Immunotherapy, 2018
Antibodies that naturally develop in some individuals infected with human immunodeficiency virus 1 (HIV-1) and are capable of broadly neutralizing diverse strains of HIV-1 are useful for two applications: they can inform the rational design of vaccine ...
Rajesh Kumar, Suprit Deshpande, Jayanta Bhattacharya   +2 more
exaly   +2 more sources

Function and structure of broadly neutralizing antibodies against SARS-CoV-2 Omicron variants isolated from prototype strain infected convalescents [PDF]

Journal of Translational Medicine
Background The ongoing emergence of evolving SARS-CoV-2 variants poses great threaten to the efficacy of authorized monoclonal antibody-based passive immunization or treatments. Developing potent broadly neutralizing antibodies (bNabs) against SARS-CoV-2
Dan Li, Caiqin Hu, Junwei Su, Shuo Du, Ying Zhang, Wanqi Ni, Li Ren, Yanling Hao, Yi Feng, Changzhong Jin, Shuo Wang, Xinxian Dai, Zheng Wang, Biao Zhu, Junyu Xiao, Yiming Shao   +15 more
doaj   +2 more sources

Rational Design and In Vivo Characterization of mRNA-Encoded Broadly Neutralizing Antibody Combinations against HIV-1

Antibodies, 2022
Monoclonal antibodies have been used successfully as recombinant protein therapy; however, for HIV, multiple broadly neutralizing antibodies may be necessary.
Elisabeth Narayanan, Samantha Falcone, Sayda M. Elbashir, Husain Attarwala, Kimberly Hassett, Michael S. Seaman, Andrea Carfi, Sunny Himansu   +7 more
doaj   +1 more source