Results 11 to 20 of about 871,553 (293)
Broadly Neutralizing Antibodies for HIV-1 Prevention [PDF]
Frontiers in Immunology, 2021 Given the absence of an effective vaccine for protection against HIV-1 infection, passive immunization strategies that utilize potent broadly neutralizing antibodies (bnAbs) to block acquisition of HIV-1 are being rigorously pursued in the clinical ...
Stephen R. Walsh, Michael S. Seaman
doaj +3 more sources
Broadly Neutralizing Antibodies for HIV Eradication [PDF]
Current HIV/AIDS Reports, 2016 Passive transfer of antibodies has long been considered a potential treatment modality for infectious diseases, including HIV. Early efforts to use antibodies to suppress HIV replication, however, were largely unsuccessful, as the antibodies that were studied neutralized only a relatively narrow spectrum of viral strains and were not very potent ...
Stephenson, Kathryn, Barouch, Dan
openaire +6 more sources
Cross-reactive broadly neutralizing antibodies: timing is everything
Frontiers in Immunology, 2012 The recent surge of research into new broadly neutralizing antibodies in HIV-1 infection has recharged the field of HIV-1 vaccinology. In this review we discuss the currently known broadly neutralizing antibodies and focus on factors that may shape these
Zelda eEuler +2 more
doaj +2 more sources
Natural Evolution of Broadly Neutralizing Antibodies [PDF]
Cell, 2015 Wu et al. couple next-generation sequencing with structural analysis to illuminate the key processes that enable the natural evolution and selection of broadly neutralizing antibodies to HIV-1, providing a potential roadmap for the development of HIV-1 vaccine strategies to accelerate the induction of protective antibodies.
Alter, Galit, Barouch, Dan H.
openaire +4 more sources
The expanding array of HIV broadly neutralizing antibodies [PDF]
Retrovirology, 2018 A large array of broadly neutralizing antibodies (bnAbs) against HIV have been isolated and described, particularly in the last decade. This continually expanding array of bnAbs has crucially led to the identification of novel epitopes on the HIV ...
Laura E. McCoy
doaj +4 more sources
Polyfunctionality of broadly neutralizing HIV-1 antibodies
Current Opinion in HIV and AIDS, 2023 Purpose of review The discovery of broadly neutralizing HIV-1 antibodies (bNAbs) has provided a framework for vaccine design and created new hope toward an HIV-1 cure. These antibodies recognize the HIV-1 Envelope and inhibit viral fusion with unprecedented breadth and potency. Beyond their unique neutralization capacity, bNAbs
Vrignaud, Lou-Léna +2 more
openaire +4 more sources
bNAber: database of broadly neutralizing HIV antibodies [PDF]
Nucleic Acids Research, 2013 The discovery of broadly neutralizing antibodies (bNAbs) has provided an enormous impetus to the HIV vaccine research and to entire immunology. The bNAber database at http://bNAber.org provides open, user-friendly access to detailed data on the rapidly growing list of HIV bNAbs, including neutralization profiles, sequences and three-dimensional ...
Alexey M. Eroshkin +8 more
openaire +6 more sources
Defining criteria for broadly neutralizing HIV antibodies
Frontiers in ImmunologyOver the course of a few years, a small percentage of individuals with HIV-1 develop broadly neutralizing antibodies (bnAbs) capable of neutralizing diverse viruses.
Elizabeth-Sharon David-Fung +5 more
doaj +3 more sources
Broadly Neutralizing Antiviral Antibodies
Annual Review of Immunology, 2013 A fascinating aspect of viral evolution relates to the ability of viruses to escape the adaptive immune response. The widely held view has been that the great variability of viral glycoproteins would be an absolute obstacle to the development of antibody-based therapies or vaccines that could confer broad and long-lasting protection.
Corti D., Lanzavecchia A.
openaire +4 more sources
Broadly neutralizing antibodies to prevent HIV-1
Science, 2017 Studies show the potential of synthetic and combinations of broadly neutralizing ...
Myron S, Cohen, Lawrence, Corey
openaire +3 more sources