Results 101 to 110 of about 1,727,618 (310)

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

A fine-tuned yeast surface-display/secretion platform enables the rapid discovery of neutralizing antibodies against Clostridioides difficile toxins

Microbial Cell Factories, 2023
Background Neutralizing antibody plays a key role in protecting hosts from invasive pathogens and their virulent components. Current high-throughput assays for antibody screening are based on binding activities.
Ying Sun, Yongrong Zhang, Hua Yu, Ashley Saint Fleur, Di Yu, Zhiyong Yang, Hanping Feng   +6 more
doaj   +1 more source

Characterization of neutralizing antibodies from a SARS-CoV-2 infected individual

bioRxiv, 2020
B cells specific for the SARS-CoV-2 S envelope glycoprotein spike were isolated from a COVID-19-infected subject using a stabilized spike-derived ectodomain (S2P) twenty-one days post-infection.
Emilie Seydoux, Leah J. Homad, Anna J. MacCamy, K. Parks, K. Parks, N. Hurlburt, Madeleine F. Jennewein, N. R. Akins, A. Stuart, Yu-Hsin Wan, Junli Feng, R. E. Nelson, Suruchi Singh, Kristen W. Cohen, M. McElrath, M. McElrath, J. Englund, H. Chu, M. Pancera, M. Pancera, Andrew T. McGuire, Andrew T. McGuire, L. Stamatatos, L. Stamatatos   +23 more
semanticscholar   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Induction of Neutralizing Antibodies to Papillomaviruses by Anti-idiotypic Antibodies

Virology, 1995
Anti-idiotypic antibodies (anti-Ids) were generated against three mouse monoclonal antibodies (MAbs) which neutralized three different papillomaviruses. The neutralizing MAbs (N-MAbs) were generated against infectious human papillomavirus type 11 (HPV-11), cottontail rabbit papillomavirus (CRPV), and bovine papillomavirus type 1 (BPV-1), and all ...
Nancy M. Cladel, Cynthia A. Reed, Neil D. Christensen   +2 more
openaire   +3 more sources

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

Nature, 2021
E. Cameroni, John E. Bowen, Laura E. Rosen, C. Saliba, Samantha K. Zepeda, K. Culap, D. Pinto, L. VanBlargan, A. De Marco, J. di Iulio, F. Zatta, Hannah Kaiser, Julia Noack, Nisar Farhat, N. Czudnochowski, C. Havenar-Daughton, Kaitlin R. Sprouse, J. Dillen, Abigail E. Powell, Alex K Chen, Cyrus Maher, Li Yin, David Sun, Leah B. Soriaga, J. Bassi, C. Silacci-Fregni, C. Gustafsson, N. Franko, J. Logue, N. Iqbal, I. Mazzitelli, J. Geffner, R. Grifantini, H. Chu, A. Gori, A. Riva, O. Giannini, A. Ceschi, P. Ferrari, Pietro E. Cippà, A. Franzetti-Pellanda, C. Garzoni, P. Halfmann, Y. Kawaoka, C. Hebner, L. Purcell, L. Piccoli, M. Pizzuto, A. Walls, M. Diamond, A. Telenti, H. Virgin, A. Lanzavecchia, G. Snell, D. Veesler, D. Corti   +55 more
semanticscholar   +1 more source

3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht, Majd Machour, Inbal Michael, Maria Bulatova, Janette Zavin, Shulamit Levenberg   +5 more
wiley   +1 more source

SARS-CoV-2 Neutralizing Antibodies 2.0

Viruses
As the SARS-CoV-2 mutates, especially into those variants causing immune escape, COVID-19 continues to wreak havoc [...]
Youchun Wang
doaj   +1 more source