Results 131 to 140 of about 1,849,608 (371)

Vaccine-induced skewing of T cell responses protects against Chikungunya virus disease [PDF]

, 2019
Chikungunya virus (CHIKV) infections can cause severe and debilitating joint and muscular pain that can be long lasting. Current CHIKV vaccines under development rely on the generation of neutralizing antibodies for protection; however, the role of T ...
Ando, Takeshi, Broeckel, Rebecca M, Curiel, David T, DeFilippis, Victor, Denton, Michael, Dmitriev, Igor, Haese, Nicole, Heise, Mark, Kreklywich, Craig N, Messaoudi, Ilhem, Morrison, Thomas E, Powers, John, Smith, Patricia, Streblow, Daniel N   +13 more
core   +3 more sources

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Evolution of cross-neutralizing antibody specificities to the CD4-BS and the carbohydrate cloak of the HIV Env in an HIV-1-infected subject. [PDF]

PLoS ONE, 2012
Broadly neutralizing antibodies are considered an important part of a successful HIV vaccine. A better understanding of the factors underlying their development during infection and of the epitopes they target is needed to elicit similar antibody ...
Iliyana Mikell, Leonidas Stamatatos
doaj   +1 more source

The evolution of the mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and America [PDF]

arXiv, 2021
The importance of understanding SARS-CoV-2 evolution cannot be overemphasized. Recent studies confirm that natural selection is the dominating mechanism of SARS-CoV-2 evolution, which favors mutations that strengthen viral infectivity. We demonstrate that vaccine-breakthrough or antibody-resistant mutations provide a new mechanism of viral evolution ...
arxiv  

SARS-CoV-2 neutralizing antibodies; longevity, breadth, and evasion by emerging viral variants

medRxiv, 2020
The SARS-CoV-2 antibody neutralization response and its evasion by emerging viral variants are unknown. Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus-cell fusion, and infectious SARS-CoV-2 ...
F. Tea, A. Stella, A. Aggarwal, David R Darley, D. Pilli, D. Vitale, V. Merheb, Fiona X. Z. Lee, P. Cunningham, G. Walker, David A. Brown, W. Rawlinson, Sonia R Isaacs, Vennila Mathivanan, Markus Hoffman, Stefan Pöhlmann, Dominic E. Dwyer, Rebeca Rockett, V. Sintchenko, Veronica C. Hoad, D. Irving, G. Dore, Iain B. Gosbell, A. Kelleher, G. Matthews, F. Brilot, S. Turville   +26 more
semanticscholar   +1 more source

3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht, Majd Machour, Inbal Michael, Maria Bulatova, Janette Zavin, Shulamit Levenberg   +5 more
wiley   +1 more source

A fine-tuned yeast surface-display/secretion platform enables the rapid discovery of neutralizing antibodies against Clostridioides difficile toxins

Microbial Cell Factories, 2023
Background Neutralizing antibody plays a key role in protecting hosts from invasive pathogens and their virulent components. Current high-throughput assays for antibody screening are based on binding activities.
Ying Sun, Yongrong Zhang, Hua Yu, Ashley Saint Fleur, Di Yu, Zhiyong Yang, Hanping Feng   +6 more
doaj   +1 more source

Characterization of neutralizing antibodies from a SARS-CoV-2 infected individual

bioRxiv, 2020
B cells specific for the SARS-CoV-2 S envelope glycoprotein spike were isolated from a COVID-19-infected subject using a stabilized spike-derived ectodomain (S2P) twenty-one days post-infection.
Emilie Seydoux, Leah J. Homad, Anna J. MacCamy, K. Parks, K. Parks, N. Hurlburt, Madeleine F. Jennewein, N. R. Akins, A. Stuart, Yu-Hsin Wan, Junli Feng, R. E. Nelson, Suruchi Singh, Kristen W. Cohen, M. McElrath, M. McElrath, J. Englund, H. Chu, M. Pancera, M. Pancera, Andrew T. McGuire, Andrew T. McGuire, L. Stamatatos, L. Stamatatos   +23 more
semanticscholar   +1 more source

Neutralizing Antibody Response and SARS Severity

Emerging Infectious Diseases, 2005
Using the Taiwan nationwide laboratory-confirmed severe acute respiratory syndrome (SARS) database, we analyzed neutralizing antibody in relation to clinical outcomes. With a linear mixed model, neutralizing antibody titer was shown to peak between week 5 and week 8 after onset and to decline thereafter, with a half-life of 6.4 weeks.
Ho, Mei-Shang, Chen, Wei-Ju, Chen, Hour-Young, Lin, Szu-Fong, Wang, Min-Chin, Di, Jiali, Lu, Yen-Ta, Liu, Ching-Lung, Chang, Shan-Chwen, Chao, Chung-Liang, King, Chwan-Chuen, Chiou, Jeng-Min, Su, Ih-Jen, Yang, Jyh-Yuan   +13 more
openaire   +5 more sources

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source