Results 151 to 160 of about 180,168 (218)

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Algorithm-Optimized H5 Influenza mRNA Vaccine Induces Broad Immune Responses. [PDF]

Int J Mol Sci
Wang L, Peng Z, He C, Zhang J, Yu P, Huang W, Wang Y, Zhao C.   +7 more
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

CircRNA based bi-antigen vaccines against mpox virus induce potent and durable cross-protection in mice. [PDF]

Mol Biomed
Zhou J, Wang C, Wu Y, Zhao B, Yang Y, Ye T, Zhang K, Li F, Hu J, Zhang K, Liu F, Wang W, Wang C, Wang Z, Chuai X, Chiu S.   +15 more
europepmc   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

A cocktail of SARS-CoV-2 S stem helix domain and receptor binding domain human monoclonal antibodies prevents the emergence of viral escape mutants. [PDF]

Microbiol Spectr
Ma Y, Ye C, Piepenbrink MS, Mahmoud SH, Cupic A, Castro E, Jackson N, Bayoumi M, Padron AS, García-Sastre A, Ippolito GC, Walter MR, Kobie JJ, Martinez-Sobrido L.   +13 more
europepmc   +1 more source

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

Preparation and epitope mapping of broad-spectrum neutralizing monoclonal antibodies against economically important pestiviruses. [PDF]

Vet Res
Liu Z, Mi S, He S, Wu M, Bao F, Feng Y, Wang Z, Xu L, Pan X, Tu C, Li J, Gong W.   +11 more
europepmc   +1 more source

Seroepidemiologic Study of Oropouche Virus, Amazonas State, Brazil, 2015-2016. [PDF]

Emerg Infect Dis
Forato J, Scachetti GC, Salgado BB, Singh CML, Pereira NC, Dos Santos Reis R, de Souza WM, Proenca-Modena JL, Lalwani P.   +8 more
europepmc   +1 more source

Determinants of success and failure of antibody-based strategies against respiratory viruses: insights from RSV and SARS-CoV-2. [PDF]

Front Immunol
Guo H, Wang H, Wu S, Lin H, Wang G, Pu Q.   +5 more
europepmc   +1 more source