Results 11 to 20 of about 1,849,608 (371)

Cross-reactive broadly neutralizing antibodies: timing is everything [PDF]

Frontiers in Immunology, 2012
The recent surge of research into new broadly neutralizing antibodies in HIV-1 infection has recharged the field of HIV-1 vaccinology. In this review we discuss the currently known broadly neutralizing antibodies and focus on factors that may shape these
Hanneke Schuitemaker, Zelda Euler
core   +3 more sources

Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus [PDF]

Cell Reports, 2017
Drug combinations are synergistic when their combined efficacy exceeds the sum of the individual actions, but they rarely include ineffective drugs that become effective only in combination. We identified several "enabling pairs" of neutralizing and non-neutralizing anti-ebolavirus monoclonal antibodies, whose combination exhibited new functional ...
Ana I. Kuehne, Frederick W. Holtsberg, M. Javad Aman, Andrew S. McNeal, Hannah L. Turner, Edgar Davidson, John M. Dye, Christopher Bryan, Benjamin J. Doranz, Andrew B. Ward, Xiangguo Qiu, Xiangguo Qiu, Katie A. Howell, Andrew S. Herbert, Hong Vu, Jennifer M. Brannan, Shihua He, Shihua He, Sergey Shulenin   +18 more
openaire   +4 more sources

The potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the envelope protein [PDF]

mBio, 2013
Following natural dengue virus (DENV) infection, humans produce some antibodies that recognize only the serotype of infection (type specific) and others that cross-react with all four serotypes (cross-reactive).
Austin, S. Kyle, Crowe, James E, Jr., de Alwis, A. Ruklanthi, de Silva, Aravinda M, Diamond, Michael S, Doranz, Benjamin J, Harris, Eva, Ibarra, Kristie D, Kahle, Kristen M, Kose, Nurgun, Pfaff, Jennifer M, Smith, Scott A, Sukupolvi-Petty, Soila, Xiang, Xiaoxiao   +13 more
core   +5 more sources

Human antibodies neutralizing diphtheria toxin in vitro and in vivo. [PDF]

Sci Rep, 2020
Diphtheria is an infectious disease caused by Corynebacterium diphtheriae. The bacterium primarily infects the throat and upper airways and the produced diphtheria toxin (DT), which binds to the elongation factor 2 and blocks protein synthesis, can ...
Wenzel EV, Bosnak M, Tierney R, Schubert M, Brown J, Dübel S, Efstratiou A, Sesardic D, Stickings P, Hust M.   +9 more
europepmc   +2 more sources

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Nature, 2021
The SARS-CoV-2 B.1.1.529 (Omicron) variant contains 15 mutations of the receptor-binding domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies requires immediate investigation.
Yunlong Cao, Jing Wang, F. Jian, T. Xiao, Weiliang Song, A. Yisimayi, Weijing Huang, Qian-qian Li, Peng Wang, R. An, Jing Wang, Yao Wang, Xiaowei Niu, Sijie Yang, Huitong Liang, Haiyan Sun, Taojing Li, Yuanling Yu, Qianqian Cui, Shuo Liu, Xiaodong Yang, Shuo Du, Zhiying Zhang, Xiaohua Hao, Fei Shao, R. Jin, Xiangxi Wang, Junyu Xiao, Youchun Wang, X. Xie   +29 more
semanticscholar   +1 more source

Antibody Response to SARS-CoV-2 among COVID-19 Confirmed Cases and Correlates with Neutralizing Assay in a Subgroup of Patients in Delhi National Capital Region, India

Vaccines, 2022
Background: The plaque reduction neutralization test (PRNT) is the gold standard to detect the neutralizing capacity of serum antibodies. Neutralizing antibodies confer protection against further infection.
Puneet Misra, Shashi Kant, Randeep Guleria, Sanjay K. Rai, Abhishek Jaiswal, Suprakash Mandal, Guruprasad R. Medigeshi, Mohammad Ahmad, Anisur Rahman, Meenu Sangral, Kapil Yadav, Mohan Bairwa, Partha Haldar, Parveen Kumar   +13 more
doaj   +1 more source

Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and B. [PDF]

PLoS One, 2016
Botulinum neurotoxins (BoNTs) are counted among the most toxic substances known and are responsible for human botulism, a life-threatening disease characterized by flaccid muscle paralysis that occurs naturally by food poisoning or colonization of the ...
Miethe S, Mazuet C, Liu Y, Tierney R, Rasetti-Escargueil C, Avril A, Frenzel A, Thullier P, Pelat T, Urbain R, Fontayne A, Sesardic D, Hust M, Popoff MR.   +13 more
europepmc   +2 more sources

A new strategy: identification of specific antibodies for neutralizing epitope on SARS-CoV-2 S protein by LC-MS/MS combined with immune repertoire

Molecular Biomedicine, 2022
Although the SARS-CoV-2 vaccine has been widely used worldwide, not all individuals can produce neutralization antibodies, so it is still urgent to find and prepare neutralization antibodies for COVID-19 prevention or treatment. In this study, we created
Meng Yu, Zhu Zhu, Yanqun Wang, Pingzhang Wang, Xiaodong Jia, Jie Wang, Lei Liu, Wanbing Liu, Yaqiong Zheng, Guomei Kou, Weiyan Xu, Jing Huang, Fengmin Lu, Xiajuan Zou, Shangen Zheng, Yinying Lu, Jincun Zhao, Hui Dai, Xiaoyan Qiu   +18 more
doaj   +1 more source

Neutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination

Nature Network Boston, 2022
The recent emergence of the SARS-CoV-2 Omicron variant is raising concerns because of its increased transmissibility and its numerous spike mutations, which have the potential to evade neutralizing antibodies elicited by COVID-19 vaccines.
E. Pérez-Then, C. Lucas, V. Monteiro, M. Mirić, V. Brache, L. Cochón, C. Vogels, A. Malik, Elena De la Cruz, A. Jorge, M. De los Santos, P. León, M. Breban, K. Billig, I. Yildirim, C. Pearson, R. Downing, E. Gagnon, A. Muyombwe, J. Razeq, M. Campbell, A. Ko, S. Omer, N. Grubaugh, S. Vermund, A. Iwasaki   +25 more
semanticscholar   +1 more source

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Nature reviews. Immunology, 2022
The ancestral strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a number of variants of concern. In this Review, Wang and colleagues discuss progress in the development and characterization of broadly neutralizing ...
Yanjia Chen, Xiaoyu Zhao, Hao Zhou, Huanzhang Zhu, Shibo Jiang, Pengfei Wang   +5 more
semanticscholar   +1 more source