Results 191 to 200 of about 1,849,608 (371)

Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction

Advanced Materials, EarlyView.
The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These micro‐robots, administered through microneedles, can penetrate deep into the tissue, effectively delivering therapeutic payloads to facilitate heart repair.
Fangfang Wang, Zilu Xu, Feiyang Zheng, Dongcheng Yang, Kaige Xu, Ming Ke, Xiao Zhou, Xiaohan Zhang, Ju Tan, Yong Liu, Yansha Hao, Malcolm Xing, Chuhong Zhu   +12 more
wiley   +1 more source

Large-scale analysis of B-cell epitopes on influenza virus hemagglutinin - implications for cross-reactivity of neutralizing antibodies

Frontiers in Immunology, 2014
Influenza viruses continue to cause substantial morbidity and mortality worldwide. Fast gene mutation on surface proteins of influenza virus result in increasing resistance to current vaccines and available antiviral drugs.
Jing eSun, Jing eSun, Ulrich eKudahl, Ulrich eKudahl, Zhiwei eCao, Christian eSimon, Christian eSimon, Ellis L Reinherz, Ellis L Reinherz, Ellis L Reinherz, Vladimir eBrusic, Vladimir eBrusic   +11 more
doaj   +1 more source

Hydrogel‐Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases

Advanced Materials, EarlyView.
This study presents a hyaluronan‐based hydrogel platform preserving the native tumor microenvironment (morphology, tissue composition, histology) of patient‐derived explants from peritoneal metastases, enabling clinically relevant drug screening. Hydrogel properties such as stiffness and degradation are crucial for longer‐term histoculture.
Kenny Zhuoran Wu, Rockie Haiyao Ding, Zixuan Zhao, Clara Yieh Lin Chong, Ruochii You, Hengjia Zhou, Dong Hua Seah, Wei Qiang Leow, Hong Kit Lim, Sukanya Shyamasundar, Kanishka Fernando, Fathima Farzana Kuthubudeen, Gillian Ng, Chor Yong Tay, Narayanan Gopalakrishna Iyer, Chin‐Ann Johnny Ong, Eliza Li Shan Fong   +16 more
wiley   +1 more source

Bioxolography Using Diphenyliodonium Chloride and N‐Vinylpyrrolidone Enables Rapid High‐Resolution Volumetric 3D Printing of Spatially Encoded Living Matter

Advanced Materials, EarlyView.
Bioxolography, a novel volumetric 3D‐bioprinting technique, enables rapid and high‐resolution fabrication of >1 cm3 engineered living materials. A newly developed three‐component photoinitiator system significantly enhances the photoreactivity of gelatin methacryloyl‐based bioresins, allowing for precise xolographic bioprinting.
Alexis Wolfel, Castro Johnbosco, Annalise Anspach, Marieke Meteling, Jos Olijve, Niklas Felix König, Jeroen Leijten   +6 more
wiley   +1 more source

Polyanhydride‐Based Microparticles for Programmable Pulsatile Release of Diphtheria Toxoid (DT) for Single‐Injection Self‐Boosting Vaccines

Advanced Materials, EarlyView.
This study presents a polyanhydride‐based delivery platform for single‐injection, self‐boosting vaccines. The system enables programmable, pulsatile release of diphtheria toxoid with high antigen recovery and is guided by machine learning for tunability. In vivo results show immune responses comparable to multi‐dose regimens, highlighting its potential
Linzixuan Zhang, Ruiqing Xiao, Wenhao Gao, Johnny Garcia, Xinyan Pan, John L. Daristotle, Timothy Forster, Jooli Han, Mehr Chaddah, Dhruv Varshney, Nandita Menon, Kevin J. McHugh, Benjamin J. Pedretti, Jing Ying Yeo, Xin Yang, Sydney MacDonald, Robert Langer, Ana Jaklenec   +17 more
wiley   +1 more source

Function and structure of broadly neutralizing antibodies against SARS-CoV-2 Omicron variants isolated from prototype strain infected convalescents

Journal of Translational Medicine
Background The ongoing emergence of evolving SARS-CoV-2 variants poses great threaten to the efficacy of authorized monoclonal antibody-based passive immunization or treatments. Developing potent broadly neutralizing antibodies (bNabs) against SARS-CoV-2
Dan Li, Caiqin Hu, Junwei Su, Shuo Du, Ying Zhang, Wanqi Ni, Li Ren, Yanling Hao, Yi Feng, Changzhong Jin, Shuo Wang, Xinxian Dai, Zheng Wang, Biao Zhu, Junyu Xiao, Yiming Shao   +15 more
doaj   +1 more source

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

Nature, 2021
U. Şahin, A. Muik, I. Vogler, E. Derhovanessian, L. Kranz, M. Vormehr, Jasmin Quandt, Nicole Bidmon, Alexander Ulges, A. Baum, Kristen E. Pascal, D. Maurus, Sebastian Brachtendorf, Verena Lörks, Julian Sikorski, Peter Koch, R. Hilker, D. Becker, A. Eller, J. Grützner, Manuel Tonigold, Carsten Boesler, Corinna Rosenbaum, L. Heesen, Marie-Cristine Kühnle, A. Poran, Jesse Z. Dong, U. Luxemburger, Alexandra Kemmer-Brück, D. Langer, M. Bexon, S. Bolte, T. Palanché, A. Schultz, S. Baumann, Azita J. Mahiny, G. Boros, J. Reinholz, G. Szabó, K. Karikó, P. Shi, Camila R. Fontes-Garfias, John L. Perez, Mark Cutler, David Cooper, C. Kyratsous, P. Dormitzer, K. Jansen, Ö. Türeci   +48 more
semanticscholar   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Broadly neutralizing antibodies against Omicron variants of SARS-CoV-2 derived from mRNA-lipid nanoparticle-immunized mice

Heliyon, 2023
The COVID-19 pandemic continues to threaten human health worldwide as new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge. Currently, the predominant circulating strains around the world are Omicron variants, which can
Ruei-Min Lu, Kang-Hao Liang, Hsiao-Ling Chiang, Fu-Fei Hsu, Hsiu-Ting Lin, Wan-Yu Chen, Feng-Yi Ke, Monika Kumari, Yu-Chi Chou, Mi-Hua Tao, Yi-Ling Lin, Han-Chung Wu   +11 more
doaj  

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source