Results 311 to 320 of about 1,849,608 (371)

Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways

Animal Models and Experimental Medicine, EarlyView.
The flowchart of this research. Abstract Background Dry eye disease (DED) predominantly results from elevated tear film osmolarity, which can not only cause ocular inconvenience but may lead to visual impairments, severely compromising patient well‐being and exerting substantial economic burdens as well.
Ziyu Liu, Yaqiong Li, Jiayu Bao, Siyuan Li, Ya Wen, Peng Zhang, Jun Feng, Yinghui Wang, Lei Tian, Ying Jie   +9 more
wiley   +1 more source

CHIKV mRNA vaccines encoding conserved structural/envelope proteins confer broad cross-lineage protection against infection. [PDF]

Signal Transduct Target Ther
Liang X, Zhou Y, Yang Y, Li Q, Wang J, Li B, Yang H, Tang C, Yu W, Wang H, Huang Q, Chen H, Yan Y, An R, Lin D, Quan W, Zhang Y, Li Y, Du X, Yuan Y, Yuan L, Zhou J, Sun Q, Wang Y, Lu S.   +24 more
europepmc   +1 more source

Critical Role for Transglutaminase 2 in Scleroderma Skin Fibrosis and in the Development of Dermal Sclerosis in a Mouse Model of Scleroderma

Arthritis &Rheumatology, EarlyView.
Objective Scleroderma is a life‐threatening autoimmune disease characterized by inflammation, tissue remodeling, and fibrosis. This study aimed to investigate the expression and function of transglutaminase 2 (TGM2) in scleroderma skin and experimentally induced dermal fibrosis to determine its potential role and therapeutic implications.
Angela Y. Y. Tam, Korsa Khan, Shiwen Xu, Marianne Bergin, Linghong Huang, Erik Arroyo Colon, Danyi Cheng, Elisabetta A. M. Verderio, Voon Ong, Christopher P. Denton, John Atkinson, Tim S. Johnson, David J. Abraham   +12 more
wiley   +1 more source

The seroprevalence of adenoviruses since 2000¹. [PDF]

Emerg Microbes Infect
Hong L, Li J, Zeng W, Li Y, Yu C, Zhao S, Chen L, Feng Y.   +7 more
europepmc   +1 more source

Efficacy, Safety, Pharmacokinetics, and Immunogenicity of ABBV‐154 in Adults With Glucocorticoid‐Dependent Polymyalgia Rheumatica: A Phase 2, Randomized, Double‐Blind, Placebo‐Controlled Trial

Arthritis &Rheumatology, EarlyView.
Objective An unmet need exists for glucocorticoid‐sparing treatments for patients with polymyalgia rheumatica (PMR). The antibody‐drug conjugate ABBV‐154 comprises adalimumab conjugated to a glucocorticoid receptor modulator. We evaluated ABBV‐154 versus placebo in patients with glucocorticoid‐dependent PMR.
Robert F. Spiera, Valerie Devauchelle‐Pensec, Claire E. Owen, Federico Díaz‐González, Tsutomu Takeuchi, Edit Drescher, Jaclyn Anderson, Dilek Arikan, Ronilda D'Cunha, Julie Parmentier, Denise T. Kruzikas, Weihan Zhao, Yang Yang, Karen Stellpflug, Frank Buttgereit   +14 more
wiley   +1 more source

An intranasally administered IgM protects against antigenically distinct subtypes of influenza A viruses. [PDF]

Nat Commun
Ramesh AK, Sivaccumar JP, Ye X, Yang L, Guo H, Chin CN, Ha S, Shiver JW, Strohl WR, Xu Y, Du H, Zhou T, Zhang N, Xu K, Liu X, Fu TM, An Z.   +16 more
europepmc   +1 more source

Sustained Interferon Signature Suppression With Anifrolumab in a Patient With STING‐Associated Vasculopathy with Onset in Infancy Refractory to JAK Inhibitor and Dazukibart Therapy

Arthritis &Rheumatology, EarlyView.
Objective The objective was to report the safety and efficacy of an anti‐IFNAR1 antibody (anifrolumab) in a patient with STING‐associated vasculopathy with onset in infancy (SAVI) who presented with vasculitic ulcers and systemic inflammation refractory to JAK inhibition (JAKi) and to the interferon‐β–neutralizing monoclonal antibody dazukibart ...
Sara Alehashemi, Bjoern Buehring, Adriana A. de Jesus, Sachin Gaurav, Andre Rastegar, Alexi Baumgardner, Kip Friend, Oluwatobi T. Arisa, William D. Figg, Danielle Fink, Douglas B. Kuhns, Ben Colton, Cody J. Peer, Raphaela Goldbach‐Mansky   +13 more
wiley   +1 more source

Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein. [PDF]

Elife
Waki K, Tani H, Kawahara E, Saga Y, Shimada T, Yamazaki E, Koike S, Morinaga Y, Isobe M, Kurosawa N.   +9 more
europepmc   +1 more source

Influence of anti-Spike protein antibody levels on tocilizumab efficacy in hospitalized patients with severe COVID-19 pneumonia: a post-hoc analysis of the COVACTA trial. [PDF]

BMC Infect Dis
Aguareles J, Forné C, García-Casas A, Santamaría-Corral G, Carnevali-Ruiz D, Sotres-Fernández G, Solera JT, Guisado-Vasco P.   +7 more
europepmc   +1 more source

Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and TYK2 Inhibitors via IL10 Antagonism

Arthritis &Rheumatology, Accepted Article.
Background JAK inhibition (JAKi) is effective in seronegative spondyloarthropathy (SpA) spectrum disorders, but TYK2 inhibition failed in SpA spectrum ulcerative colitis, and tofacitinib showed minimal benefit in Crohn's Disease, which highlights the complex role for JAK‐STAT signaling in different inflammatory processes. In this study, we investigated
Sami Giryes, Chi Wong, Charlie Bridgewood, Mark Harland, Ala Altaie, Nicole McDermott, Kerem Abacar, Abhay Rao, Almas Khan, Tristan McMillan, Peter Loughenbery, Robert Dunsmuir, Vishal Borse, Tom Macleod, Dennis McGonagle   +14 more
wiley   +1 more source