Results 61 to 70 of about 1,849,608 (371)
SARS-CoV-2 Neutralizing Antibodies for COVID-19 Prevention and Treatment.
Annual Review of Medicine, 2021 Prophylactic and therapeutic drugs are urgently needed to combat coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Dapeng Li +4 more
semanticscholar +1 more source
TIV vaccination modulates host responses to influenza virus infection that correlate with protection against bacterial superinfection [PDF]
, 2019 Background: Influenza virus infection predisposes to secondary bacterial pneumonia. Currently licensed influenza vaccines aim at the induction of neutralizing antibodies and are less effective if the induction of neutralizing antibodies is low and/or the
Choi, Angela +4 more
core +2 more sources
PLoS Neglected Tropical Diseases, 2023 Infections with Chikungunya virus, a mosquito-borne alphavirus, cause an acute febrile syndrome often followed by chronic arthritis that persists for months to years post-infection.
John M Powers +12 more
doaj +1 more source
Neutralizing Antibodies Responses to SARS-CoV-2 in COVID-19 Inpatients and Convalescent Patients
medRxiv, 2020 Background. COVID-19 is a pandemic with no specific antiviral treatments or vaccines. The urgent needs for exploring the neutralizing antibodies from patients with different clinical characteristics are emerging. Methods.
Xiaoli Wang +8 more
semanticscholar +1 more source
When does humoral memory enhance infection? [PDF]
arXiv, 2023 Antibodies and humoral memory are key components of the adaptive immune system. We consider and computationally model mechanisms by which humoral memory present at baseline might instead increase infection load; we refer to this effect as EI-HM (enhancement of infection by humoral memory). We first consider antibody dependent enhancement (ADE) in which
arxiv
Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies
PLoS Pathogens, 2021 Understanding SARS-CoV-2 evolution and host immunity is critical to control COVID-19 pandemics. At the core is an arms-race between SARS-CoV-2 antibody and angiotensin-converting enzyme 2 (ACE2) recognition, a function of the viral protein spike ...
Marta Alenquer +14 more
semanticscholar +1 more source
Vaccines, 2023 This study aimed to analyze the dynamics, duration, and production of total and neutralizing antibodies induced by the BNT162b2 vaccine and the possible effect of gender and prior SARS-CoV-2 infection on the generation of these antibodies.
Jorge Hernández-Bello +6 more
doaj +1 more source
Deciphering antibody affinity maturation with language models and weakly supervised learning [PDF]
arXiv, 2021 In response to pathogens, the adaptive immune system generates specific antibodies that bind and neutralize foreign antigens. Understanding the composition of an individual's immune repertoire can provide insights into this process and reveal potential therapeutic antibodies. In this work, we explore the application of antibody-specific language models
arxiv
Neutralizing antiviral antibody responses
, 2001 Neutralizing antibodies are evolutionarily important effectors of immunity against viruses. Their evaluation has revealed a number of basic insights into specificity, rules of reactivity (tolerance), and memory—namely, (1) Specificity of neutralizing antibodies is defined by their capacity to distinguish between virus serotypes; (2) B cell reactivity ...
Zinkernagel, R +9 more
openaire +3 more sources
Iterative Refinement Graph Neural Network for Antibody Sequence-Structure Co-design [PDF]
arXiv, 2021 Antibodies are versatile proteins that bind to pathogens like viruses and stimulate the adaptive immune system. The specificity of antibody binding is determined by complementarity-determining regions (CDRs) at the tips of these Y-shaped proteins. In this paper, we propose a generative model to automatically design the CDRs of antibodies with enhanced ...
arxiv