Results 21 to 30 of about 514,317 (292)
How Can Immune Checkpoint Inhibitors Cause Hyperprogression in Solid Tumors?
Frontiers in Immunology, 2020 Following the administration of immune checkpoint inhibitors, an unexpected pattern of response designated as hyperprogression may be observed in certain patients.
Morgane Denis +6 more
doaj +1 more source
Cells, 2023 Serum amyloid A (SAA) proteins belong to a family of acute-phase reactants, playing an integral role in defending the organism from pathological damage.
Ralfs Buks +6 more
doaj +1 more source
Antibody Representation Learning for Drug Discovery [PDF]
arXiv, 2022 Therapeutic antibody development has become an increasingly popular approach for drug development. To date, antibody therapeutics are largely developed using large scale experimental screens of antibody libraries containing hundreds of millions of antibody sequences.
arxiv
ASAP-SML: An Antibody Sequence Analysis Pipeline Using Statistical Testing and Machine Learning [PDF]
, 2020 Antibodies are capable of potently and specifically binding individual antigens and, in some cases, disrupting their functions. The key challenge in generating antibody-based inhibitors is the lack of fundamental information relating sequences of antibodies to their unique properties as inhibitors.
arxiv +1 more source
Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity [PDF]
, 2020 Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4-CXCL4) and polyanions (P) opsonize PF4-coated bacteria hereby mediating bacterial host defense. A subset of these antibodies may activate platelets after binding to PF4-heparin complexes, causing the prothrombotic adverse drug reaction heparin-induced thrombocytopenia (HIT).
arxiv +1 more source
Acknowledgement to Reviewers of Antibodies in 2017
Antibodies, 2018 Peer review is an essential part in the publication process, ensuring that Antibodies maintains high quality standards for its published papers.[...]
Antibodies Editorial Office
doaj +1 more source
Improving antibody language models with native pairing [PDF]
arXiv, 2023 Current antibody language models are limited by their use of unpaired antibody sequence data and the biases in publicly available antibody sequence datasets, which are skewed toward antibodies against a relatively small number of pathogens. A recently published dataset (by Jaffe, et al) of approximately 1.6 x 10^6 natively paired human antibody ...
arxiv
BiomedicinesTherapeutic antibodies (Abs) which act on a broader range of epitopes may provide more durable protection against the genetic drift of a target, typical of viruses or tumors.
Ilse Roodink +20 more
doaj +1 more source
Acknowledgement to Reviewers of Antibodies in 2013
Antibodies, 2014 The editors of Antibodies would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2013.
Antibodies Editorial Office
doaj +1 more source
When Two are Better than One: Modeling the Mechanisms of Antibody Mixtures [PDF]
, 2019 It is difficult to predict how antibodies will behave when mixed together, even after each has been independently characterized. Here, we present a statistical mechanical model for the activity of antibody mixtures that accounts for whether pairs of antibodies bind to distinct or overlapping epitopes.
arxiv +1 more source