Results 201 to 210 of about 311,268 (263)
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Antibody-Dependent Cell-Mediated Cytotoxicity
The Journal of Immunology, 1974Abstract Macrophages obtained from peritoneal exudate are effector cells for antibody-dependent cytotoxicity. This effector function is independent of phagocytosis, and it is not inhibited by EDTA or aminophylline. Cells functionally similar to those in peritoneal exudate can be obtained from the spleen, but a functionally different ...
Juan Carlos Scornik, Humberto Cosenza
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Complement enhances antiviral antibody-dependent cell cytotoxicity
Nature, 1977ANTIBODY-DEPENDENT cell cytotoxicity (ADCC) is an in vitro phenomenon that can be demonstrated with a variety of target cell systems and can be mediated by several types of effector cells1–3. The effectors in ADCC must bear a surface receptor for Fc, and this receptor binds with antibody which is in turn bound to the target cell.
B T, Rouse, A S, Grewal, L A, Babiuk
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Antibody-dependent cell-mediated cytotoxicity in pigs
American Journal of Veterinary Research, 1982SUMMARY Development of antibody-dependent cell-mediated cytotoxicity (adcc) was studied in cells obtained from porcine fetal and neonatal tissues. Pulmonary washouts, hepatic tissues, splenic tissues, and neutrophil fractions of blood were sources of cells.
A, Zarkower +4 more
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Human lymphoblast cell lines: Antibody‐dependent cytotoxicity
European Journal of Immunology, 1975AbstractFive cell lines were isolated after prolonged culture of human buffy coat leukocytes. The cells consisted for the most part of lymphoblasts morphologically similar to those produced by in vivo or in vitro stimulation of small lymphocytes by antigens or mitogens. One of the lines possessed virus‐like particles of the Epstein‐Barr type.
J C, Lefebre +3 more
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Enzymatic Enhancement of Cell-Mediated Cytotoxicity and Antibody-Dependent Cell Cytotoxicity
The Journal of Immunology, 1974Abstract The effects of papain, trypsin, Pronase, neuraminidase, and phospholipase C on in vitro cell-mediated cytotoxicity (CMC) and antibody-dependent cell cytotoxicity (ADCC) have been studied in a syngeneic tumor system. Proteolytic enzyme treatment of lymphoid (effector) cells at low concentrations (<0.1 mg/ml) and for short ...
E, Kedar +2 more
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Bovine antibody dependent cell-mediated cytotoxicity (ADCC) effector cells
Veterinary Immunology and Immunopathology, 1987ADCC effector cells from bovine blood were separated by centrifugation, adherence and rosetting techniques. Each enriched cell population, peripheral blood mononuclear cells (PBM), null lymphocytes, monocytes and neutrophils, was then examined for its capacity to mediate ADCC.
E L, Belden, H M, Peng
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Journal of Visualized Experiments
The method for antibody-dependent, cell-mediated cytotoxicity (ADCC) represents an important tool to assess the efficacy of therapeutic antibodies in cancer immunotherapy. Evaluating ADCC activity in cancer cells is essential for the development and optimization of antibody-based treatments.
Kelvin Kam Yew, Kuan +4 more
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The method for antibody-dependent, cell-mediated cytotoxicity (ADCC) represents an important tool to assess the efficacy of therapeutic antibodies in cancer immunotherapy. Evaluating ADCC activity in cancer cells is essential for the development and optimization of antibody-based treatments.
Kelvin Kam Yew, Kuan +4 more
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SELECTIVE REACTIONS IN ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY
Transplantation, 1977Selective reactions associated with HLA specificity were sought in antibody-dependent cell-mediated cytotoxic tests against HLA-typed lymphoblastoid lines using operationally monospecific HLA sera and effector cells from healthy individuals. Precise detection of HLA specificities was disturbed by the presence of natural antibodies in HLA antiserum and ...
J, Takasugi, M, Takasugi
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Reversible blocking of antibody-dependent cell-mediated cytotoxicity
Cellular Immunology, 1977Abstract The ability of human peripheral blood lymphocytes to kill antibody-coated Chang liver cells in antibody-dependent cell-mediated cytotoxicity (ADCC) can be blocked with aggregated IgG (agg-IgG) or by soluble immune complexes. Dissociation of aggregates of IgG or immune complexes from the cell surface, however, resulted in partial recovery of ...
K, Sugamura, J B, Smith
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Antibody-Dependent Cell-Mediated Cytotoxicity in Humans
The Journal of Immunology, 1975Abstract Mononuclear cells from human peripheral blood are able to destroy alloantibody-coated target cells of a human lymphoblastoid line. The effector cell is a nonadherent, non-phagocytic, medium sized lymphoid cell. This cell is not detectable in early human fetuses.
Giorgio Trinchieri +3 more
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