Results 101 to 110 of about 2,312,760 (293)

Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies

Transplant International
Recently, interest in transcriptomic assessment of kidney biopsies has been growing. This study investigates the use of NGS to identify gene expression changes and analyse the pathways involved in rejection.
Esteban Cortes Garcia, Alessia Giarraputo, Maud Racapé, Valentin Goutaudier, Cindy Ursule-Dufait, Pierre de la Grange, Lucie Adoux, Marc Raynaud, Clément Couderau, Fariza Mezine, Jessie Dagobert, Oriol Bestard, Francesc Moreso, Jean Villard, Fabian Halleck, Magali Giral, Sophie Brouard, Richard Danger, Pierre-Antoine Gourraud, Marion Rabant, Lionel Couzi, Moglie Le Quintrec, Nassim Kamar, Emmanuel Morelon, François Vrtovsnik, Jean-Luc Taupin, Renaud Snanoudj, Christophe Legendre, Christophe Legendre, Dany Anglicheau, Dany Anglicheau, Klemens Budde, Carmen Lefaucheur, Carmen Lefaucheur, Alexandre Loupy, Alexandre Loupy, Olivier Aubert, Olivier Aubert   +37 more
doaj   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant [PDF]

, 2017
Transplant rejection is the critical clinical end-point limiting indefinite survival after histocompatibility antigen (HLA) mismatched organ transplantation. The predominant cause of late graft loss is antibody-mediated rejection (AMR), a process whereby
Jieming Chen, Annette M. Jackson, Silvia Pineda, Minnie M. Sarwal, Pineda, Silvia, Jackson, Annette M, Pineda Sanjuan, Silvia, Tara K. Sigdel, Marina Sirota, Sarwal, Minnie M., Sarwal, Minnie M, Sigdel, Tara K, Jackson, Annette M., Chen, Jieming, Sirota, Marina   +14 more
core   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source

Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection

Journal of Immunology Research, 2017
Consistent with Dr. Paul Terasaki’s “humoral theory of rejection” numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies
Carrie L. Butler, Nicole M. Valenzuela, Kimberly A. Thomas, Elaine F. Reed   +3 more
doaj   +1 more source

A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects

Advanced Science, EarlyView.
Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song, Zhewei Shuai, Weiyan Sun, Liang Chen, Yiwei Shen, Jiateng Hu, Yuanqi Ma, Jie Luo, Meilin Huang, Yan Luo, Yunlang She, Guangdong Zhou, Chang Chen, Dong Lei   +13 more
wiley   +1 more source

Disulfiram treatment suppresses antibody-producing reactions by inhibiting macrophage activation and B cell pyrimidine metabolism

Communications Biology
Antibody responses, involving B cells, CD4 + T cells, and macrophages, are implicated in autoimmune diseases and organ transplant rejection. We have previously shown that inhibiting FROUNT with disulfiram (DSF) suppresses macrophage activation and ...
Weili Chen, Etsuko Toda, Kazuhiro Takeuchi, Yurika Sawa, Kyoko Wakamatsu, Naomi Kuwahara, Arimi Ishikawa, Yuri Igarashi, Mika Terasaki, Shinobu Kunugi, Yasuhiro Terasaki, Kazuhiko Yamada, Yuya Terashima, Akira Shimizu   +13 more
doaj   +1 more source

Antibody-Mediated Rejection [PDF]

American Journal of Transplantation, 2020
openaire   +2 more sources

Comparison of rejection-free survival.

, 2019
(a) Biopsy-proven acute rejection free survival in HLAi, ABOi, HLAi+ABOi, control, and LD control groups. (b) Active antibody-mediated rejection free survival in HLAi, ABOi, HLAi+ABOi, control, and LD control groups. Abbreviations: ABOi, ABO-incompatible;
Eun Sang Yoo (7423334), Jeong-Hoon Lim (4488172), Seung Huh (4516735), Dong-Il Won (1499863), Yong-Lim Kim (277264), Jang-Hee Cho (503441), Hee-Yeon Jung (249364), Hyung-Kee Kim (4516726), Ji-Young Choi (488316), Sun-Hee Park (503442), Chan-Duck Kim (503443)   +10 more
core   +1 more source