Results 91 to 100 of about 2,312,760 (293)

Chronic Renal Allograft Dysfunction Antibody-Mediated: An Update [PDF]

, 2014
This paper reviews the most important studies on chronic antibody-mediated rejection (cABMR), which is an important cause of late graft dysfunction after renal transplantation.
Elisabetta Bertoni, Maurizio Salvadori,
core  

A model of acute antibody-mediated renal allograft rejection in the sensitized rat [PDF]

, 2018
Objectives: Antibody-mediated rejection in transplant recipients with preexisting donor-specific antibodies is a challenging clinical situation. However, we lack suitable animal models to study this scenario.
Chandran, Sharmila Ramessur, Mulley, William R., Ma, Frank Y., Kanellis, John, Nikolic-Paterson, David J.; id_orcid   +4 more
core   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Acute antibody-mediated rejection after pancreas transplantation [PDF]

Einstein (São Paulo), 2008
Objective: Acute antibody-mediated rejection requires specific treatment and has a negative impact on graft survival. The objectives were to report the incidence of antibody-mediated rejection after pancreas transplantation, the demographic data, the ...
Érika Bevilaqua Rangel, Denise Maria Avancini Costa Malheiros, Irina Antunes, Margareth Torres, Maria Cristina Ribeiro Castro, Fábio Crescentini, Tércio Genzini, Marcelo Perosa de Miranda   +7 more
doaj  

Dimensions of Antibody‐Mediated Rejection [PDF]

American Journal of Transplantation, 2010
In this issue, de Kort and colleagues report a thorough analysis of acute antibody-mediated rejection (acute AMR) in pancreas allografts. The study is an important practical reference for those working in the field of pancreas transplantation, and adds considerably to the number of published cases. The first message is that all grafts lost to rejection
openaire   +1 more source

Acute antibody-mediated rejection after ABO-incompatible kidney transplantation treated successfully with antigen-specific immunoadsorption

, 2010
ABO-incompatible kidney transplantation is possible after pre-treatment with rituximab, intravenous immunoglobulin and basiliximab combined with tacrolimus, mycophenolate mofetil and prednisolone. We report on the first patient treated with this protocol
Sprogøe, Ulrik, Koefoed-Nielsen, Pernille, Just, Søren Andreas; id_orcid, Bistrup, Claus; id_orcid, Marcussen, Niels; id_orcid   +4 more
core   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

T-cell-mediated Rejection of Vascularized Xenografts in the Absence of Induced Anti-donor Antibody Response: T cell mediated rejection

, 2002
International audienceT cells are considered to play a major indirect role in the pathogenesis of xenograft vascular rejection, by promoting the induction of anti-donor antibodies that trigger complement- and antibody-dependent cell cytotoxicity. However,
Guillet, Marina, Sébille, Fabien, Brouard, Sophie, Blancho, Gilles, Vanhove, Bernard, Gagne, Katia, Petzold, Thomas, Soulillou, Jean-Paul   +7 more
core   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Antibody-Mediated Rejection in Kidney Transplantation: A Review

, 2012
Antibody mediated rejection (AMR) poses a significant and continued challenge for long term graft survival in kidney transplantation. However, in the recent years, there has emerged an increased understanding of the varied manifestations of the antibody ...
Henkie P. Tan, Ron Shapiro, Chethan Puttarajappa   +2 more
core   +1 more source