Results 41 to 50 of about 556,937 (315)
A study of antibody secretion from hybridoma cells [PDF]
, 1988 The secretion of monoclonal antibody in both batch and continuous cultures was studied. It was found that when hybridoma cells were continuously cultivated in a simple lab scale fermenter, they secreted less antibody than cells grown in stationary ...
Holland, P.N.
core
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye +33 more
wiley +1 more source
IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression
Nature Communications, 2017 T cells help B cells to differentiate into antibody-producing plasma cells. Here the authors show that T cells produce interleukin-2 to activate ERK/ELK1 and suppress BACH2 expression by modulating the BACH2 super-enhancer, thereby altering BACH2 ...
Nicolas Hipp +7 more
doaj +1 more source
Is There a Future for Anti-CD38 Antibody Therapy in Systemic Autoimmune Diseases?
Cells, 2019 CD38 is a type II glycoprotein highly expressed on plasmablasts, short-lived and long-lived plasma cells, but weakly expressed on other lymphoid cells, myeloid cells and non-hematopoietic cells.
Devis Benfaremo, Armando Gabrielli
doaj +1 more source
Adaptive immunity in the joint of rheumatoid arthritis
Immunological Medicine, 2022 Adaptive immunity plays central roles in the pathogenesis of rheumatoid arthritis (RA), as it is regarded as an autoimmune disease. Clinical investigations revealed infiltrations of B cells in the synovium, especially those with ectopic lymphoid ...
Hisakata Yamada
doaj +1 more source
Citrus/Cydonia Comp. Can Restore the Immunological Balance in Seasonal Allergic Rhinitis-Related Immunological Parameters In Vitro [PDF]
, 2008 In two in vitro studies, we examined the immunological (pathways of the) effects of Citrus/Cydonia comp. from, respectively, a healthy and an allergic donor; peripheral blood mononuclear cells (PBMCs) were isolated out of peripheral blood and analyzed in
E. W. Baars +3 more
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Serial Transfer of Antibody Producing Cells on the Chorioallantoic Membrane.
Experimental Biology and Medicine, 1963 SummarySerial transfer of foci on the CAM through at least 3 transfers is confirmed. Significant titers of antibody were found in a high percentage of recipient eggs 5 days after inoculation of spleen cells from an immunized chicken. The transfer of cells from the CAM of these eggs to other eggs resulted in development of foci, but the proportion of ...
E P, COHEN, J S, INGRAHAM, D W, TALMAGE
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
REAL-Select: full-length antibody display and library screening by surface capture on yeast cells. [PDF]
PLoS ONE, 2014 We describe a novel approach named REAL-Select for the non-covalent display of IgG-molecules on the surface of yeast cells for the purpose of antibody engineering and selection.
Laura Rhiel +5 more
doaj +1 more source