Results 31 to 40 of about 556,937 (315)

Contribution of long-lived plasma cells to antibody-mediated allograft rejection

Clinical Transplantation and Research
Persistent alloantigens derived from allograft tissues can be recognized by the host’s alloreactive immune system. This process enables cognate B cells to differentiate into plasma cells, which secrete donor-specific antibodies that are key drivers of ...
Eunkyeong Jang, Jeehee Youn
doaj   +1 more source

Early treatment with anti-VLA-4 mAb can prevent the infiltration and/or development of pathogenic CD11b+CD4+ T cells in the CNS during progressive EAE. [PDF]

PLoS ONE, 2014
Natalizumab is a humanized monoclonal antibody against the leukocyte adhesion molecule very late antigen (VLA)-4, and is currently an approved therapy for patients with relapsing-remitting multiple sclerosis (RRMS).
John E Mindur, Naoko Ito, Suhayl Dhib-Jalbut, Kouichi Ito   +3 more
doaj   +1 more source

Antibody durability is influenced by interleukin-2 production by undifferentiated memory T helper cells and extensive B cell clonal expansion

Cell Reports
Summary: SARS-CoV-2-neutralizing antibody titers serve as immune correlates of protection against COVID-19; however, the durability varies among vaccinees.
Masanori Isogawa, Masahiro Shinoda, Ryutaro Kotaki, Kazutaka Terahara, Taishi Onodera, Kiyomi Kabasawa, Mio Toyama-Kousaka, Mizuki Fujisawa, Mitsukaze Watanabe, Keisuke Tonouchi, Tommy Terooatea, Ayumi Kitano, Yu Adachi, Saya Moriyama, Tomohiro Takano, Shuetsu Fukushi, Takayuki Matsumura, Kazuo Yamashita, Masaharu Shinkai, Yoshimasa Takahashi   +19 more
doaj   +1 more source

Human CD81 directly enhances T_h1 and T_h2 cell activation, but preferentially induces proliferation of T_h2 cells upon long-term stimulation

BMC Immunology, 2003
Background CD81, a cell-surface protein of the tetraspanin superfamily, has been shown to costimulate T cell activation in murine T cells, and is involved in development of Th2 immune responses in mice.
Maecker Holden T
doaj   +1 more source

AUTORADIOGRAPHIC STUDIES ON THE PROLIFERATION OF ANTIBODY-PRODUCING CELLS IN VITRO [PDF]

The Journal of Experimental Medicine, 1974
A rapid and reliable autoradiographic technique for plaque-forming cells (PFCs) using 14C rather than tritiated thymidine is described. Its application to PFCs developing in vitro shows that (a) practically all PFCs derive from precursors dividing steadily during the culture period, (b) PFC precursors divide in the absence of T-cell helper function ...
T, Hünig, A, Schimpl, E, Wecker
openaire   +2 more sources

IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

, 2012
It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P.
Hunter, Christopher A, Couper, Kevin N, Riley, Eleanor M, Greig, Rachel, Blount, Daniel G, Blount, Daniel G., Stumhofer, Jason S, Hafalla, Julius CR, De Souza, J. Brian, Findlay, Emily Gwyer, Shaw, Tovah N, de Souza, J Brian, Riley, Eleanor M., Shaw, Tovah N., Stumhofer, Jason S., Hunter, Christopher A., Hafalla, Julius C R, Couper, Kevin N., Gwyer Findlay, Emily, Villegas-Mendez, Ana   +19 more
core   +1 more source

REGULATORY ROLE OF OX22HIGH T-CELLS IN MERCURY-INDUCED AUTOIMMUNITY IN THE BROWN NORWAY RAT [PDF]

, 1993
The monoclonal antibody OX22 defines a functional split within CD4+ T cells in the rat, with OX22high cells mainly producing interleukin 2 (IL-2) and interferon γ and responsible for delayed-type hypersensitivity responses, and OX22low cells mainly ...
P W Mathieson, Oliveira, DBG, Thiru, S, Mathieson, PW, S Thiru, D B Oliveira, Oliveira, DB   +6 more
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

SWIFT clustering analysis of intracellular cytokine staining flow cytometry data of the HVTN 105 vaccine trial reveals high frequencies of HIV-specific CD4+ T cell responses and associations with humoral responses

Frontiers in Immunology
IntroductionThe HVTN 105 vaccine clinical trial tested four combinations of two immunogens - the DNA vaccine DNA-HIV-PT123, and the protein vaccine AIDSVAX B/E. All combinations induced substantial antibody and CD4+ T cell responses in many participants.
Tim R. Mosmann, Jonathan A. Rebhahn, Stephen C. De Rosa, Michael C. Keefer, M. Juliana McElrath, Nadine G. Rouphael, Giuseppe Pantaleo, Giuseppe Pantaleo, Peter B. Gilbert, Lawrence Corey, James J. Kobie, Juilee Thakar   +11 more
doaj   +1 more source

Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread. [PDF]

PLoS Pathogens, 2016
Skin infection with the poxvirus vaccinia (VV) elicits a powerful, inflammatory cellular response that clears virus infection in a coordinated, spatially organized manner.
Stephanie S Cush, Glennys V Reynoso, Olena Kamenyeva, Jack R Bennink, Jonathan W Yewdell, Heather D Hickman   +5 more
doaj   +1 more source