Results 11 to 20 of about 348,994 (265)

Immortalisation of Human Antibody Producing Cells

Autoimmunity, 1992
(1992). Immortalisation of Human Antibody Producing Cells. Autoimmunity: Vol. 13, No. 3, pp. 249-258.
J K, Kalsi, D A, Isenberg
openaire   +2 more sources

Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

BMC Biotechnology, 2007
Background Antibody-dependent cellular cytotoxicity (ADCC) is greatly enhanced by the absence of the core fucose of oligosaccharides attached to the Fc, and is closely related to the clinical efficacy of anticancer activity in humans in vivo ...
Shitara Kenya, Iida Shigeru, Wakitani Masako, Inoue Miho, Mori Katsuhiro, Imai-Nishiya Harue, Satoh Mitsuo   +6 more
doaj   +1 more source

Obtaining and Characterization of Hybridomas Producing Monoclonal Antibodies against Coronavirus SARS-CоV-2

Проблемы особо опасных инфекций, 2023
The aim of the work was to obtain and characterize hybridomas producing monoclonal antibodies to antigens of coronavirus SARS‑CoV‑2, promising for the construction of diagnostic immunochemical tests. Materials and methods.
G. V. Kuklina, S. S. Ipatov, A. S. Gorshkov, D. V. Pechenkin, A. V. Eremkin, A. V. Kuznetsovsky, A. S. Tumanov, I. V. Darmov   +7 more
doaj   +1 more source

CD38-targeted therapy with daratumumab reduces autoantibody levels in multiple myeloma patients

Journal of Translational Autoimmunity, 2019
Autoantibody-producing plasma cells are frequently resistant to conventional immunosuppressive treatments and B-cell depletion therapy. As a result of this resistance, autoreactive plasma cells survive conventional therapy, resulting in persistent ...
Kristine A. Frerichs, Christie P.M. Verkleij, Patricia W.C. Bosman, Sonja Zweegman, Henny Otten, Niels W.C.J. van de Donk   +5 more
doaj   +1 more source

Regulatory mechanisms of B cell responses and the implication in B cell-related diseases

Journal of Biomedical Science, 2019
Terminally differentiated B cell, the plasma cell, is the sole cell type capable of producing antibodies in our body. Over the past 30 years, the identification of many key molecules controlling B cell activation and differentiation has elucidated the ...
Dong-Yan Tsai, Kuo-Hsuan Hung, Chia-Wei Chang, Kuo-I Lin   +3 more
doaj   +1 more source

Distribution and Morphology of Antibody-Producing Cells in Dueks

The Japanese Journal of Veterinary Science, 1980
アヒルにおける抗horseradish peroxidase抗体産生細胞の分布と形態とを, 光学顕微鏡的および電子顕微鏡的免疫細胞学によって検討した. 典型的な抗体産生細胞は脾臓赤髄ないし胚中心における形質細胞または大型リンパ球であった. 胚中心域には2型の陽性細胞が区別され, そのうちで多数をしめるものは樹枝状細胞で, 他は抗体産生細胞であったが, これらの抗体産生細胞は胚中心域以外に出現したものよりも遅く出現した. 脾臓白髄における他のリンパ球, すなわち動脈周囲リンパ球, 静脈周囲リンパ球および莢中心毛細管周囲リンパ球は抗体産生像を示さなかった.
HASHIMOTO, Yoshiharu, SUGIMURA, Makoto
openaire   +3 more sources

Combination of poly I:C and Pam3CSK4 enhances activation of B cells in vitro and boosts antibody responses to protein vaccines in vivo.

PLoS ONE, 2017
Vaccines that can rapidly induce strong and robust antibody-mediated immunity could improve protection from certain infectious diseases for which current vaccine formulations are inefficient.
Genevieve M Weir, Mohan Karkada, David Hoskin, Marianne M Stanford, Lisa MacDonald, Marc Mansour, Robert S Liwski   +6 more
doaj   +1 more source

Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses. [PDF]

PLoS Pathogens, 2006
B cells can use antibody-dependent mechanisms to control latent viral infections. It is unknown whether this represents the sole function of B cells during chronic viral infection.
Kelly B McClellan, Shivaprakash Gangappa, Samuel H Speck, Herbert W Virgin   +3 more
doaj   +1 more source

Seasonal variation of immune response to heterologous erythrocytes in natural populations of red‐backed (Clethrionomys rutilus) and gray‐sided (C. rufocanus) voles in Western Siberia

Ecology and Evolution, 2022
We studied the seasonal variation of adaptive humoral immunity (AHI) in northern red‐backed vole (Clethrionomys rutilus Pallas, 1779, RBV) and gray‐sided vole (C. rufocanus Sundevall, 1846, GSV) in Tomsk region of Western Siberia.
Larisa B. Kravchenko, Konstantin A. Rogovin   +1 more
doaj   +1 more source

Detection of Tumor Cell Surface-reactive Antibodies

Bio-Protocol, 2014
Vaccine-based immunotherapy is being used to treat dogs with primary brain tumors. The vaccines are composed of a lysate of autologous tumor cells, which stimulate an immune response producing tumor specific antibodies that are capable of inducing ...
Brian Andersen, Michelle Goulart, Michael Olin, G. Pluhar   +3 more
doaj   +1 more source