Results 21 to 30 of about 348,994 (265)

Contribution of long-lived plasma cells to antibody-mediated allograft rejection

Clinical Transplantation and Research
Persistent alloantigens derived from allograft tissues can be recognized by the host’s alloreactive immune system. This process enables cognate B cells to differentiate into plasma cells, which secrete donor-specific antibodies that are key drivers of ...
Eunkyeong Jang, Jeehee Youn
doaj   +1 more source

Early treatment with anti-VLA-4 mAb can prevent the infiltration and/or development of pathogenic CD11b+CD4+ T cells in the CNS during progressive EAE. [PDF]

PLoS ONE, 2014
Natalizumab is a humanized monoclonal antibody against the leukocyte adhesion molecule very late antigen (VLA)-4, and is currently an approved therapy for patients with relapsing-remitting multiple sclerosis (RRMS).
John E Mindur, Naoko Ito, Suhayl Dhib-Jalbut, Kouichi Ito   +3 more
doaj   +1 more source

Antibody durability is influenced by interleukin-2 production by undifferentiated memory T helper cells and extensive B cell clonal expansion

Cell Reports
Summary: SARS-CoV-2-neutralizing antibody titers serve as immune correlates of protection against COVID-19; however, the durability varies among vaccinees.
Masanori Isogawa, Masahiro Shinoda, Ryutaro Kotaki, Kazutaka Terahara, Taishi Onodera, Kiyomi Kabasawa, Mio Toyama-Kousaka, Mizuki Fujisawa, Mitsukaze Watanabe, Keisuke Tonouchi, Tommy Terooatea, Ayumi Kitano, Yu Adachi, Saya Moriyama, Tomohiro Takano, Shuetsu Fukushi, Takayuki Matsumura, Kazuo Yamashita, Masaharu Shinkai, Yoshimasa Takahashi   +19 more
doaj   +1 more source

Human CD81 directly enhances T_h1 and T_h2 cell activation, but preferentially induces proliferation of T_h2 cells upon long-term stimulation

BMC Immunology, 2003
Background CD81, a cell-surface protein of the tetraspanin superfamily, has been shown to costimulate T cell activation in murine T cells, and is involved in development of Th2 immune responses in mice.
Maecker Holden T
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread. [PDF]

PLoS Pathogens, 2016
Skin infection with the poxvirus vaccinia (VV) elicits a powerful, inflammatory cellular response that clears virus infection in a coordinated, spatially organized manner.
Stephanie S Cush, Glennys V Reynoso, Olena Kamenyeva, Jack R Bennink, Jonathan W Yewdell, Heather D Hickman   +5 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

SWIFT clustering analysis of intracellular cytokine staining flow cytometry data of the HVTN 105 vaccine trial reveals high frequencies of HIV-specific CD4+ T cell responses and associations with humoral responses

Frontiers in Immunology
IntroductionThe HVTN 105 vaccine clinical trial tested four combinations of two immunogens - the DNA vaccine DNA-HIV-PT123, and the protein vaccine AIDSVAX B/E. All combinations induced substantial antibody and CD4+ T cell responses in many participants.
Tim R. Mosmann, Jonathan A. Rebhahn, Stephen C. De Rosa, Michael C. Keefer, M. Juliana McElrath, Nadine G. Rouphael, Giuseppe Pantaleo, Giuseppe Pantaleo, Peter B. Gilbert, Lawrence Corey, James J. Kobie, Juilee Thakar   +11 more
doaj   +1 more source

IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression

Nature Communications, 2017
T cells help B cells to differentiate into antibody-producing plasma cells. Here the authors show that T cells produce interleukin-2 to activate ERK/ELK1 and suppress BACH2 expression by modulating the BACH2 super-enhancer, thereby altering BACH2 ...
Nicolas Hipp, Hannah Symington, Cédric Pastoret, Gersende Caron, Céline Monvoisin, Karin Tarte, Thierry Fest, Céline Delaloy   +7 more
doaj   +1 more source

Is There a Future for Anti-CD38 Antibody Therapy in Systemic Autoimmune Diseases?

Cells, 2019
CD38 is a type II glycoprotein highly expressed on plasmablasts, short-lived and long-lived plasma cells, but weakly expressed on other lymphoid cells, myeloid cells and non-hematopoietic cells.
Devis Benfaremo, Armando Gabrielli
doaj   +1 more source