Results 91 to 100 of about 3,380,570 (289)

Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

Frontiers in Immunology, 2019
Myeloid-derived suppressor cells (MDSCs) play crucial roles in tumorigenesis and their inhibition is critical for successful cancer immunotherapy.
Dehong Yan, Adeleye O. Adeshakin, Adeleye O. Adeshakin, Meichen Xu, Meichen Xu, Lukman O. Afolabi, Lukman O. Afolabi, Guizhong Zhang, Youhai H. Chen, Xiaochun Wan, Xiaochun Wan   +10 more
doaj   +1 more source

Synthesis and biodistribution of immunoconjugates of a human IgM and polymeric drug carriers [PDF]

, 1992
The synthesis and purification of radiolabelled immunoconjugates, composed of a human IgM monoclonal antibody directed against an intracellular tumour-associated antigen and either poly (alpha-L-glutamic acid) (PGA) or poly[N5-(2-hydroxyethyl)-L ...
Anderson, James M., Boon, P.J., Bos, E.S., Feijen, J., Grootoonk, J., Hoes, C.J.T., Kaspersen, F., Loeffen, P., Schlachter, I., Winters, M.   +9 more
core   +2 more sources

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

Nature Communications, 2018
Native-like soluble HIV envelope (Env) trimers are potential vaccine immunogens, and elimination of furin-dependence could provide a DNA-based alternative. Here, Sarkar et al.
Anita Sarkar, Shridhar Bale, Anna-Janina Behrens, Sonu Kumar, Shailendra Kumar Sharma, Natalia de Val, Jesper Pallesen, Adriana Irimia, Devan C. Diwanji, Robyn L. Stanfield, Andrew B. Ward, Max Crispin, Richard T. Wyatt, Ian A. Wilson   +13 more
doaj   +1 more source

A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen. [PDF]

, 2018
Anti-carbohydrate monoclonal antibodies (mAbs) hold great promise as cancer therapeutics and diagnostics. However, their specificity can be mixed, and detailed characterization is problematic, because antibody-glycan complexes are challenging to ...
Amon, Ron, Chen, Xi, Fleishman, Sarel J, Glushka, John N, Grant, Oliver C, Leviatan Ben-Arye, Shani, Makeneni, Spandana, Marshanski, Tal, Nivedha, Anita K, Norn, Christoffer, Padler-Karavani, Vered, Woods, Robert J, Yu, Hai   +12 more
core   +2 more sources

Role of M3 Muscarinic Acethylcholine Receptor Antibodies as a New Marker in Primary Sjögren Syndrome [PDF]

, 2017
Aims: This paper investigates the presence of M3 muscarinic acetylcholine receptor autoantibody present in the serum of patients with primary Sjögren syndrome (pSS).
Borda, Enri Santiago, Ganzinelli, Sabrina Belen, González Arana, Roberto, Pisoni, Cecilia, Reina, Silvia Lorena   +4 more
core   +1 more source

IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design [PDF]

, 2017
Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules, which retain the specificity of the rodent antibody but ...
Angal, Bole, Borth, Breedveld, Chloe L. Stoyle, David P. Humphreys, Du, Durocher, Ellgaard, Feige, Feige, Freeze, Heath, Hendershot, Hendershot, Hu, Hubbard, Iwamoto, Katharine Cain, Leitzgen, Mains, Mason, Minegishi, Neil J. Bulleid, Nguyen, Paul E. Stephens, Peters, Sam Heywood, Schellenberger, Slanina, Spiess, Thies, Werther, Yang, Zou   +34 more
core   +1 more source

Monoclonal Antibodies

Dermatologic Clinics, 2015
Use of monoclonal antibodies (mAbs) has revolutionized cancer therapy. Approaches targeting specific cellular targets on the malignant cells and in tumor microenvironment have been proved to be successful in hematologic malignancies, including cutaneous lymphomas.
openaire   +2 more sources

Role of hydrophobic interaction in hapten-antibody binding [PDF]

, 1977
The precipitation reaction of bovine serum albumin coupled with p-azophenylleucine with homologous antibody was inhibited by several structurally related haptens. The isobutyl group substituent on alpha-carbon atom of the leucine residue contributed more
Hatase, Osamu, Hayashi, Hideo, Koide, Noriko, Oda, Takuzo, Tomoda, Jun, Tsutsui, Ken   +5 more
core   +1 more source

Antibody and Antibody Mimetic Immunotherapeutics [PDF]

Future Medicinal Chemistry, 2017
Brian R. McNaughton, Angeline N. Ta
openaire   +2 more sources

Mutation N856K in spike reduces fusogenicity and infectivity of Omicron BA.1

Signal Transduction and Targeted Therapy, 2023
Chunyun Sun, Huiyu Wang, Ji Yang, Desheng Kong, Yuning Chen, Haiyue Wang, Lingling Sun, Jianbo Lu, Min Teng, Liangzhi Xie   +9 more
doaj   +1 more source