Results 11 to 20 of about 5,152,668 (337)
Communications Biology, 2021 Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting.
Lu Shan +12 more
doaj +1 more source
Convergent Antibody Responses to SARS-CoV-2 in Convalescent Individuals
Nature, 2020 During the coronavirus disease-2019 (COVID-19) pandemic, severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has led to the infection of millions of people and has claimed hundreds of thousands of lives. The entry of the virus into cells
D. Robbiani +45 more
semanticscholar +1 more source
IgG Fc engineering to modulate antibody effector functions
Protein & Cell, 2017 Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions.
Xinhua Wang +2 more
doaj +1 more source
Methods and Protocols, 2021 Despite the public availability, finding experts in any field when relying on academic publications can be challenging, especially with the use of jargons.
Wei-Ling Wu +5 more
doaj +1 more source
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2
Science, 2020 Hitting SARS-CoV-2 in a new spot A key target for therapeutic antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the spike protein, a trimeric protein complex with each monomer comprising an S1 and an S2 domain that ...
Xiangyang Chi +23 more
semanticscholar +1 more source
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19
New England Journal of Medicine, 2020 Background Recent data suggest that complications and death from coronavirus disease 2019 (Covid-19) may be related to high viral loads. Methods In this ongoing, double-blind, phase 1–3 trial involving nonhospitalized patients with Covid-19, we ...
D. Weinreich +32 more
semanticscholar +1 more source
Tropomyosin antibody: the specific localization of tropomyosin in nonmuscle cells [PDF]
, 1975 An antibody against purified chicken skeletal muscle tropomyosin is used in indirect immunofluorescence to visualize the localization of tropomyosin in a variety of nonmuscle cells.
Lazarides, Elias
core +2 more sources
Challenges and developments in universal vaccine design against SARS-CoV-2 variants
npj Vaccines, 2022 The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had become a global concern because of its unexpectedly high pathogenicity and transmissibility.
Fangxin Zhao +4 more
doaj +1 more source
Vaccines, 2023 We previously developed a polysaccharide-–RBD-conjugated nanoparticle vaccine which induced protective efficacy against SARS-CoV-2 in a mouse model. Here, we newly developed a vaccine, SCTV01A, by chemically conjugating recombinant SARS-CoV-2 RBD-Fc and ...
Chunyun Sun +11 more
doaj +1 more source
bioRxiv, 2020 The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 800 laboratory-confirmed human infections, including 25 deaths, posing a serious threat to human health. Currently, however, there is no specific antiviral treatment or vaccine.
Xiao-long Tian +10 more
semanticscholar +1 more source