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Computational Analysis of Antibody Paratopes for Antibody Sequences in Antibody Libraries
2022To ensure the functionalities of the antibodies in phage-displayed synthetic antibody libraries, we use computational method to evaluate the designs of the antibody libraries. The computational methodologies developed in our lab for designing antibody library provide rich information on the function of the designed antibody sequences-adequate antibody ...
Hung-Pin, Peng, An-Suei, Yang
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Antibody and antibody derivatives as cancer therapeutics
WIREs Nanomedicine and Nanobiotechnology, 2019Antibodies are an important class of therapeutic for treating a wide range of diseases. These versatile macromolecules can be engineered to target many different antigens and to utilize several mechanisms of action to produce a pharmacological effect. The most common antibody platform used for therapeutics is immunoglobulin G (IgG). Advances in protein‐
Keith J. Arlotta, Shawn C. Owen
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Antiphospholipid antibodies and the antiphospholipid antibody syndrome
Drugs of Today, 2000The antiphospholipid antibody syndrome is a multisystem disorder characterized by persistently elevated antiphospholipid antibodies and/or arterial or venous thrombosis, thrombocytopenia and recurrent spontaneous abortion. Anticardiolipin antibodies and the lupus anticoagulant are different classes of antiphospholipid antibodies associated with this ...
Jensen Sl, Nahass Gt
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Pharmacological Reviews, 1982
Of all classes of compounds, antibodies provide the greatest range of specificities and affinities. The number of interatomic interactions between an antibody combining site and a large ligand such as a receptor far exceeds those between the common small ligand or drug and its corresponding binding site.1 As a result, there is increased selectivity and
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Of all classes of compounds, antibodies provide the greatest range of specificities and affinities. The number of interatomic interactions between an antibody combining site and a large ligand such as a receptor far exceeds those between the common small ligand or drug and its corresponding binding site.1 As a result, there is increased selectivity and
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Antiphospholipid antibody and antiphospholipid antibody syndrome
Current Opinion in Rheumatology, 1991New details have been added to the description of the antiphospholipid antibody syndrome. These include quantitation of risk of stroke; delineation of an associated acute occlusive vasculopathy syndrome, including its pathology; increased awareness of the association of adrenal insufficiency with antiphospholipid antibody; new demonstration of ...
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Current Opinion in Chemical Biology, 1998
Following the end of the first decade in catalytic antibody research, recent efforts are reflecting a more introspective view of the field. Notably, X-ray crystal structure analyses of antibody catalysts are permitting an increased understanding of the evolution and modus operandi of these remarkable biocatalysts. Additionally, the breadth and scope of
P, Wentworth, K D, Janda
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Following the end of the first decade in catalytic antibody research, recent efforts are reflecting a more introspective view of the field. Notably, X-ray crystal structure analyses of antibody catalysts are permitting an increased understanding of the evolution and modus operandi of these remarkable biocatalysts. Additionally, the breadth and scope of
P, Wentworth, K D, Janda
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From antibodies to sperm to antibodies in transplantation
Urology, 1998a) To assess the use of "panning" procedures for the detection of antibodies to sperm. b) To develop and use human monoclonal antibodies for the analysis of human transplantation antigens."Panning" assays were developed. The procedures and their use in the analysis of mouse monoclonal antibodies to human sperm are described.
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Antibody structure and antibody engineering
Advanced Drug Delivery Reviews, 1988Abstract Immunoglobulin (Ig) genes are efficiently expressed following transfection into myeloma cells. The heavy and light chain genes, cloned into two compatible plasmids with different selectible markers, can be delivered simultaneously into the same cell.
Lee K. Tan, Sherie L. Morrison
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Antiacetylcholinesterase antibodies: Enzyme antibodies interaction
Pharmacological Research Communications, 1981Summary Erythrocyte acetylcholinesterase activity of rabbits was significantly increased over control levels by immunization with acetylcholinesterase from the electric organ of the electric eel. The increase of enzyme activity and that of anti-acetylcholinesterase antibodies had the same time course, reaching a maximum level on the 35th day.
B. Conti-Tronconi +3 more
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Veterinary Microbiology, 2006
Herpesviruses have developed different tools to thwart efficient antibody-dependent neutralisation and lysis of virions and elimination of infected cells. This overview will briefly summarize different of these tools, including (i) viral Fc receptors and the resulting process of antibody bridging, (ii) internalization of individual viral proteins and ...
Hans Nauwynck +4 more
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Herpesviruses have developed different tools to thwart efficient antibody-dependent neutralisation and lysis of virions and elimination of infected cells. This overview will briefly summarize different of these tools, including (i) viral Fc receptors and the resulting process of antibody bridging, (ii) internalization of individual viral proteins and ...
Hans Nauwynck +4 more
openaire +3 more sources