Results 241 to 250 of about 2,490,885 (297)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Multiplex serology reveals age-specific immunodynamics of respiratory pathogens in the wake of the COVID-19 pandemic. [PDF]

Nat Commun
Bents SJ, Martin ET, Stevens-Ayers T, Andrews C, Adler A, Perofsky AC, Krantz EM, Blazevic R, Kimball L, Prentice R, Hansen C, Starita L, Han P, Englund JA, Wolter N, von Gottberg A, Maake L, Moyes J, Cohen C, Boeckh M, Hay JA, Waghmare A, Viboud C.   +22 more
europepmc   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

SARS-CoV-2 animal vaccine with cross-protection against Wuhan strain and delta variant. [PDF]

Sci Rep
Ga E, Won Y, Hwang J, Moon S, Xie X, Yeom M, Lim JW, Song D, Lyoo KS, Na W.   +9 more
europepmc   +1 more source

Longitudinal Study of Salivary Biomarkers in the Definition of Clinico‐Molecular Progression of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo, Daniele Belvisi, Matteo Costanzo, Claudia Caturano, Francesco Emanuele Bellomi, Carolina Cutrona, Flavia Aiello, Giorgio Leodori, Massimo Marano, Romina Mancinelli, Antonella Conte, Giovanni Fabbrini, Alfredo Berardelli, Giorgio Vivacqua   +13 more
wiley   +1 more source

Convergent mutation trajectories convert functional self-tolerance in IGHV4-34 B cells to genetic tolerance encoded in the antibody. [PDF]

Proc Natl Acad Sci U S A
Jara CJ, Zachariah S, Jackson KJL, Peters TJ, Masle-Farquhar E, Burnett DL, Lam E, Faulks M, Russell A, Miosge L, Smith S, Tscharke DC, Brink R, Goodnow CC, Reed JH.   +14 more
europepmc   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Generation of a <i>scFv</i> Derived from an IgM-Producing Hybridoma for the Detection of REST Expression in Premalignant Lesions and Invasive Squamous Cell Carcinoma. [PDF]

Int J Mol Sci
Rodríguez-Nava C, Cortés-Sarabia K, Riaño-Umbarila L, Becerril-Luján B, Medina-Flores Y, Mata-Ruíz O, Lloret-Sánchez L, Illades-Aguiar B, Alarcón-Romero LDC, Ortuño-Pineda C.   +9 more
europepmc   +1 more source

COVID-19-Associated MDA5-Mediated Necrotizing Myositis. [PDF]

Am J Case Rep
Steadman S, Sikder A, Desai HR, Collins B, Baker T, Worthington J.   +5 more
europepmc   +1 more source