Results 241 to 250 of about 3,741,108 (338)

A novel single-vector featuring bidirectional promoters for production of bispecific antibody against rabies virus. [PDF]

BMC Biotechnol
Zhang Z, Li J, Lin G, Cao S, Wu Y.
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Detection of PEG-specific antibodies in SARS-CoV-2 positive and negative sera with implications for autoimmune reactivity. [PDF]

Sci Rep
Vojdani A, Vojdani E.
europepmc   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Positive rates of <i>Mycoplasma pneumoniae</i> antibodies in children before, during and after COVID-19 outbreak: an observational study in Chengdu, China from 2017 to 2024. [PDF]

Front Microbiol
Yan L, Dong H, Zhang H, Du Z, Lai M, Zhang L.   +5 more
europepmc   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

Neutralizing Antibodies vs. Viruses: Interacting Mechanisms and Escape Tactics. [PDF]

Microorganisms
Lu H, Liu Y, Song Y, Chen L, Zhang L, Li R, Nie X, Zhu G, Ding X, Wang L.   +9 more
europepmc   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Correction: Shikonin inhibits NLRP3 inflammasome activation and controls inflammatory disease

Scientific Reports
Jing Huang, Mengmeng Dai, Xinyu Huang, Wenqing Qi, Jing Jing, Jiayi He, Zhizhuo Lu, Chaofang Zhang, Guiling Wang, Run Cao, Yuanfang Ma, Hailong Zhang   +11 more
doaj   +1 more source

APP SUMOylation prevents BACE1 cleavage of APP and increases BACE1 degradation to promote the nonamyloidogenic pathway. [PDF]

Mol Med
Liu YC, Hsu WL, Ma YL, Yin CY, Cheng KM, Lee EHY.   +5 more
europepmc   +1 more source