Results 31 to 40 of about 5,128,022 (309)

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

bioRxiv, 2020
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 800 laboratory-confirmed human infections, including 25 deaths, posing a serious threat to human health. Currently, however, there is no specific antiviral treatment or vaccine.
Xiao-long Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zhènglì Shí, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu, T. Ying   +10 more
semanticscholar   +1 more source

Improving sensitivity of oral fluid testing in IgG prevalence studies: application of mixture models to a rubella antibody survey [PDF]

, 2003
A method for the analysis of age-stratified antibody prevalence surveys is applied to a previously reported survey of antibody to rubella virus using oral fluid samples in which the sensitivity of the assay used was shown to be compromised.
Enquselassie, F., Gay, N. J., Nigatu, Wondatir, Nokes, D. James, Vyse, A. J.   +4 more
core   +2 more sources

A Polysaccharide-RBD-Fc-Conjugated COVID-19 Vaccine, SCTV01A, Showed High Immunogenicity and Low Toxicity in Animal Models

Vaccines, 2023
We previously developed a polysaccharide-–RBD-conjugated nanoparticle vaccine which induced protective efficacy against SARS-CoV-2 in a mouse model. Here, we newly developed a vaccine, SCTV01A, by chemically conjugating recombinant SARS-CoV-2 RBD-Fc and ...
Chunyun Sun, Desheng Kong, Erhong Guo, Jun Zhao, Jilei Jia, Rui Wang, Juan Ma, Meng Chen, Jianbo Lu, Chulin Yu, Kuokuo Li, Liangzhi Xie   +11 more
doaj   +1 more source

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

Science, 2020
An antibody cocktail against SARS-CoV-2 There is an urgent focus on antibodies that target the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral spike and prevent the virus from entering host cells. Hansen et al.
J. Hansen, A. Baum, Kristen E. Pascal, Vincenzo Russo, Stephanie Giordano, Elzbieta Wloga, Benjamin O. Fulton, Ying Yan, Katrina Koon, Krunal Patel, K. Chung, Aynur Hermann, Erica Ullman, Jonathan Cruz, A. Rafique, Tammy Huang, J. Fairhurst, Christen Libertiny, M. Malbec, Wen-yi Lee, R. Welsh, Glen Farr, Seth Pennington, D. Deshpande, Jemmie Cheng, A. Watty, P. Bouffard, R. Babb, N. Levenkova, Calvin R. Chen, Bojie Zhang, Annabel Romero Hernandez, K. Saotome, Yi Zhou, M. Franklin, S. Sivapalasingam, D. Lye, S. Weston, James Logue, Robert E. Haupt, M. Frieman, Gang Chen, W. Olson, A. Murphy, N. Stahl, G. Yancopoulos, C. Kyratsous   +46 more
semanticscholar   +1 more source

Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic [PDF]

, 2015
Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the ...
Boyle, Ross, Bryden, Francesca, Caddick, Stephen, Chudasama, Vijay, Maruani, Antoine, Savoie, Huguette   +5 more
core   +2 more sources

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

Science, 2020
An antibody cocktail against SARS-CoV-2 There is an urgent focus on antibodies that target the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral spike and prevent the virus from entering host cells. Hansen et al.
A. Baum, Benjamin O. Fulton, Elzbieta Wloga, R. Copin, Kristen E. Pascal, Vincenzo Russo, Stephanie Giordano, Kathryn Lanza, N. Negron, M. Ni, Yi Wei, G. Atwal, A. Murphy, N. Stahl, G. Yancopoulos, C. Kyratsous   +15 more
semanticscholar   +1 more source

Bispecific antibodies

Drug Discovery Today, 2015
Bispecific antibodies have emerged as molecules with a multitude of ...
Kontermann, Roland E., Brinkmann, Ulrich
openaire   +3 more sources

Combined DNA extraction and antibody elution from filter papers for the assessment of malaria transmission intensity in epidemiological studies. [PDF]

, 2013
BACKGROUND: Informing and evaluating malaria control efforts relies on knowledge of local transmission dynamics. Serological and molecular tools have demonstrated great sensitivity to quantify transmission intensity in low endemic settings where the ...
Baidjoe, Amrish, Bousema, Teun, Cox, Jonathan, Drakeley, Chris, Grignard, Lynn, Kariuki, Simon, Makori, Euniah, Osoti, Victor, Ploemen, Ivo, Sauerwein, Robert, Shagari, Shehu, Stevenson, Jennifer, Stone, Will, Sutherland, Colin   +13 more
core   +3 more sources

Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.

New England Journal of Medicine, 2012
BACKGROUND Programmed death 1 (PD-1) protein, a T-cell coinhibitory receptor, and one of its ligands, PD-L1, play a pivotal role in the ability of tumor cells to evade the host's immune system.
J. Brahmer, S. Tykodi, L. Chow, W. Hwu, S. Topalian, P. Hwu, C. Drake, L. Camacho, J. Kauh, K. Odunsi, H. Pitot, O. Hamid, S. Bhatia, R. Martins, K. Eaton, Shuming Chen, Theresa M Salay, S. Alaparthy, J. Grosso, A. Korman, S. Parker, S. Agrawal, S. M. Goldberg, D. Pardoll, A. Gupta, J. Wigginton   +25 more
semanticscholar   +1 more source

Construction and Immunological Evaluation of an Adenoviral Vector-Based Vaccine Candidate for Lassa Fever

Viruses, 2021
Lassa virus (LASV) is a rodent-borne arenavirus circulating in West African regions that causes Lassa fever (LF). LF is normally asymptomatic at the initial infection stage, but can progress to severe disease with multiorgan collapse and hemorrhagic ...
Meirong Wang, Ruihua Li, Yaohui Li, Changming Yu, Xiangyang Chi, Shipo Wu, Shulin Liu, Junjie Xu, Wei Chen   +8 more
doaj   +1 more source