Results 41 to 50 of about 3,380,570 (289)
A novel one-step approach for the construction of yeast surface display Fab antibody libraries
Microbial Cell Factories, 2018 Background Yeast surface display (YSD) has proven to be a versatile platform technology for antibody discovery. However, the construction of antibody Fab libraries typically is a tedious three-step process that involves the generation of heavy chain as ...
Simon Rosowski +10 more
doaj +1 more source
mAbs, 2021 Hybridoma technology has been valuable in the development of therapeutic antibodies. More recently, antigen-specific B-cell selection and display technologies are also gaining importance. A major limitation of these approaches used for antibody discovery
Ruijun Zhang +15 more
doaj +1 more source
Improving antibody language models with native pairing [PDF]
arXiv, 2023 Current antibody language models are limited by their use of unpaired antibody sequence data and the biases in publicly available antibody sequence datasets, which are skewed toward antibodies against a relatively small number of pathogens. A recently published dataset (by Jaffe, et al) of approximately 1.6 x 10^6 natively paired human antibody ...
arxiv
When Two are Better than One: Modeling the Mechanisms of Antibody Mixtures [PDF]
, 2019 It is difficult to predict how antibodies will behave when mixed together, even after each has been independently characterized. Here, we present a statistical mechanical model for the activity of antibody mixtures that accounts for whether pairs of antibodies bind to distinct or overlapping epitopes.
arxiv +1 more source
AntiBARTy Diffusion for Property Guided Antibody Design [PDF]
arXiv, 2023 Over the past decade, antibodies have steadily grown in therapeutic importance thanks to their high specificity and low risk of adverse effects compared to other drug modalities. While traditional antibody discovery is primarily wet lab driven, the rapid improvement of ML-based generative modeling has made in-silico approaches an increasingly viable ...
arxiv
No association between islet cell antibodies and coxsackie B, mumps, rubella and cytomegalovirus antibodies in non-diabetic individuals aged 7–19 years [PDF]
, 1991 Viral antibodies were tested in a cohort of 44 isletcell antibody-positive individuals age 7–19 years, and 44 of their islet cell antibody-negative age and sex-matched classmates selected from a population study of 4208 pupils who had been screened for ...
A Tarn +32 more
core +1 more source
Modelling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion [PDF]
, 2016 We have developed a mathematical framework for describing a bispecific monoclonal antibody interaction with two independent membrane-bound targets that are expressed on the same cell surface.
Argungu, Maryam +8 more
core +1 more source
Encephalitis with mGluR5 antibodies [PDF]
Neurology, 2018 To report the clinical features of 11 patients with metabotropic glutamate receptor 5 (mGluR5) antibody-associated encephalitis, immunoglobulin G (IgG) subclass, and effects of the antibodies on neuronal mGluR5 clusters.Clinical information was retrospectively obtained from referring physicians.
Spatola, Marianna +15 more
openaire +4 more sources
Journal of Immunology Research, 2019 To improve efficacy and minimize toxicity of EGFR inhibition treatment, we developed Ame55, a novel anti-EGFR IgG1 with lower affinity to EGFR than cetuximab (C225) from a human phage library.
Weiyi Qiu +13 more
doaj +1 more source
Toxins, 2016 Tetanus neurotoxin (TeNT) produced by Clostridium tetani is one of the most poisonous protein substances. Neutralizing antibodies against TeNT can effectively prevent and cure toxicosis.
Han Wang +9 more
doaj +1 more source