Results 81 to 90 of about 5,128,022 (309)

Recombinant HSA-CMG2 Is a Promising Anthrax Toxin Inhibitor

Toxins, 2016
Anthrax toxin is the major virulence factor produced by Bacillus anthracis. Protective antigen (PA) is the key component of the toxin and has been confirmed as the main target for the development of toxin inhibitors.
Liangliang Li, Qiang Guo, Ju Liu, Jun Zhang, Ying Yin, Dayong Dong, Ling Fu, Junjie Xu, Wei Chen   +8 more
doaj   +1 more source

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

Science immunology, 2020
IgM and IgA responses to SARS-CoV-2 RBD in severe COVID patients decay rapidly, while IgG responses persist for over 3 months. We measured plasma and/or serum antibody responses to the receptor-binding domain (RBD) of the spike (S) protein of SARS-CoV-2 ...
Anita S Iyer, Forrest K. Jones, A. Nodoushani, Meagan Kelly, Margaret V Becker, D. Slater, Rachel Mills, E. Teng, M. Kamruzzaman, W. García-Beltrán, M. Astudillo, Diane Yang, T. Miller, Elizabeth Oliver, S. Fischinger, C. Atyeo, A. Iafrate, S. Calderwood, S. Lauer, Jingyou Yu, Zhenfeng Li, J. Feldman, B. Hauser, T. Caradonna, J. Branda, S. Turbett, R. Larocque, G. Mellon, D. Barouch, A. Schmidt, A. Azman, G. Alter, E. Ryan, J. Harris, R. Charles   +34 more
semanticscholar   +1 more source

Development of an antibody fragment that stabilizes GPCR/G-protein complexes. [PDF]

, 2018
Single-particle cryo-electron microscopy (cryo-EM) has recently enabled high-resolution structure determination of numerous biological macromolecular complexes.
Dawson, Roger JP, Hilger, Daniel, Hu, Hongli, Kobilka, Brian K, Koehl, Antoine, Maeda, Shoji, Manglik, Aashish, Matile, Hugues, Schertler, Gebhard FX, Skiniotis, Georgios   +9 more
core   +2 more sources

Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities

mAbs, 2022
Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by the ...
Desislava Yanakieva, Lukas Pekar, Andreas Evers, Markus Fleischer, Stephan Keller, Dirk Mueller-Pompalla, Lars Toleikis, Harald Kolmar, Stefan Zielonka, Simon Krah   +9 more
doaj   +1 more source

A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Nature Communications, 2020
Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time.
A. Huang, Bernardo García-Carreras, M. Hitchings, Bingyi Yang, L. Katzelnick, S. Rattigan, Brooke A. Borgert, Carlos A Moreno, B. Solomon, L. Trimmer-Smith, Veronique Etienne, I. Rodríguez-Barraquer, J. Lessler, H. Salje, D. Burke, A. Wesolowski, D. Cummings   +16 more
semanticscholar   +1 more source

Evaluating pre-treatment methods in the isolation and purification of monoclonal IgG antibody [PDF]

, 2008
In this study, the effects of different sample preparation techniques on the separation of monoclonal antibody IgG I were inve st igated experimentally. Monoclonal IgG I was obtained from hybridoma cell line TB /C3 transfected with bcl-2 carrier plasmid.
Abdul Majid, Fadzilah Adibah, Shian, L. P.   +1 more
core  

Nanoparticles for live cell microscopy: A surface-enhanced Raman scattering perspective. [PDF]

, 2017
Surface enhanced Raman scattering (SERS) nanoparticles are an attractive alternative to fluorescent probes for biological labeling because of their photostability and multiplexing capabilities.
Candas, Demet, Chan, James W, Chernenko, Tatyana, Fan, Ming, Li, Jian Jian, Mehrpouyan, Majid, Navas-Moreno, Maria, Yan, Ming   +7 more
core   +1 more source

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients

Science immunology, 2020
Saliva is an alternative biofluid to serum for detecting and monitoring IgG to SARS-CoV-2 spike and RBD antigens in COVID-19. While the antibody response to SARS-CoV-2 has been extensively studied in blood, relatively little is known about the antibody ...
B. Isho, K. Abe, Michelle Zuo, Alainna J. Jamal, B. Rathod, Jenny H. Wang, Zhijie Li, G. Chao, Olga L. Rojas, Yeo Myong Bang, A. Pu, Natasha Christie-Holmes, C. Gervais, D. Ceccarelli, Payman Samavarchi-Tehrani, Furkan Guvenc, P. Budylowski, A. Li, A. Paterson, F. Yue, L. M. Marin, L. Caldwell, J. Wrana, K. Colwill, F. Sicheri, S. Mubareka, S. Gray-Owen, S. Drews, W. Siqueira, M. Barrios-Rodiles, M. Ostrowski, J. Rini, Y. Durocher, A. McGeer, J. Gommerman, A. Gingras   +35 more
semanticscholar   +1 more source

SARS CoV subunit vaccine: Antibodymediated neutralisation and enhancement [PDF]

, 2012
1. A SARS vaccine was produced based on recombinant native full-length Spike-protein trimers (triSpike) and efficient establishment of a vaccination procedure in rodents. 2.
Altmeyer, R, Bruzzone, R, Cheung, CY, Daeron, M, Dutry, I, Escriou, N, Jaume, M, Kam, YW, Kien, F, Li, PH, Nal, B, Peiris, JSM, Roberts, A, Subbarao, K, Yip, MS   +14 more
core   +1 more source

The whole genomic analysis of orf virus strain HN3/12 isolated from Henan province, central China

BMC Veterinary Research, 2017
Background The Orf virus (ORFV) is the causative agent of orf, a globally-occurring, acute, pustular, contagious disease affecting sheep, goats and humans with a worldwide distribution. Currently, the genomic analysis of four ORFV strains from the Fujian
Huiqin Chen, Wei Li, Zhenzhan Kuang, Daxiang Chen, Xiaoqing Liao, Ming Li, Shuhong Luo, Wenbo Hao   +7 more
doaj   +1 more source