Results 121 to 130 of about 10,558,921 (293)
Editorial: TNFRSF agonists: mode of action and therapeutic opportunities
Frontiers in Immunology, 2023 Nataša Obermajer +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Early Diagnosis and Successful Treatment of Acute Antibody-Mediated Rejection of a Renal Transplant
, 2011 Antibody-mediated rejection is a delicate situation. it rarely occurs but when it does, it usually results in graft dysfunction and frequently, graft loss.
YANG, YA-WEN;LIN, WEI-CHOU;WU, MING-SHIOU;LEE, PO-HUANG;TSAI, MENG-KUN +1 more
core
Single scaffold antibody libraries created with high rates of mutagenesis or diversity focused for peptide recognition [PDF]
, 2007 textThis dissertation describes several strategies used to create diversity in non-immune antibody libraries. Two of the strategies were used to create two separate peptide focused libraries.
Cobaugh, Christian Wessel, 1971-
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Nanodesigner: resolving the complex-CDR interdependency with iterative refinement
Journal of CheminformaticsCamelid heavy-chain only antibodies consist of two heavy chains and single variable domains (VHHs), which retain antigen-binding functionality even when isolated.
Melissa Maria Rios Zertuche +4 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Constructing the future of design : How design professionals perceive their changing role
, 2018 Design and design thinking have boomed in the past decade, expanding design considerations into new areas of application and a wide range of organizations across industry types.
Björklund, Tua A. +2 more
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Interpretations of design thinking across a large organization
, 2019 Design thinking has a prominent role as established corporations ramp up innovation efforts focusing on user needs. Current literature provides a plethora of definitions for design thinking with variations in tools, methods and cultures.
Björklund, Tua +2 more
core +1 more source