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Therapeutic antibodies: Discovery, design and deployment
Molecular Immunology, 2015Therapeutic antibodies have come of age with major progress being made in cancer, autoimmunity and chronic inflammation, as well as a wide range of other human diseases. Antibody engineering is further driving development of novel antibody formats and genetically modified cell-based therapies that harness the power of the immune system to progress ...
Ramsland, Paul +2 more
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Design and Application of Antibody Cysteine Variants
Bioconjugate Chemistry, 2010Antibodies are multidomain proteins that are extensively used as a research tool in molecular biology and as therapeutics in medicine. In many cases, antibodies are engineered to contain surface cysteines for the site-specific conjugation of payloads.
Vladimir, Voynov +5 more
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Selection, design, and engineering of therapeutic antibodies
Journal of Allergy and Clinical Immunology, 2005mAbs account for an increasing portion of marketed human biological therapeutics. As a consequence, the importance of optimal selection, design, and engineering of these not only has expanded in the past 2 decades but also is now coming into play as a competitive factor.
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Catalytic Antibodies as Designer Proteases and Esterases
Chemical Reviews, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
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Molecular engineering and design of therapeutic antibodies
Current Opinion in Immunology, 2008Since the first murine monoclonal antibody was approved for human therapeutic use over a decade ago, the realization that monoclonal antibody therapeutics could be engineered to improve their efficacy has inspired an astonishing array of novel antibody constructs.
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New Strategies for the Design of Catalytic Antibodies
Biotechnology Progress, 1990AbstractA new approach is advanced which is aimed at expanding the scope of antibody catalysis. It entails the design and synthesis of haptens that will elicit antibodies to catalyze acyl transfer reactions by a methodology which we term “bait and switch” catalysis.
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Avidity in antibody effector functions and biotherapeutic drug design
Nature Reviews Drug Discovery, 2022Simone C Oostindie +2 more
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
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AI models for protein design are driving antibody engineering
Current Opinion in Biomedical Engineering, 2023Jeffrey J Gray
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