Results 261 to 270 of about 10,558,921 (293)

Antibody design: Beyond the natural limits

Trends in Biotechnology, 1994
Dissection of antibody-antigen interactions requires a knowledge of antibody structure, the ability to model accurately the conformation of antibody-combining sites, and an understanding of the energetic factors governing the interactions. When this understanding has reached the point where the molecular shape and chemical character of a combining site
A R, Rees, D, Staunton, D M, Webster, S J, Searle, A H, Henry, J T, Pedersen   +5 more
openaire   +2 more sources

Catalytic Antibodies as Designer Proteases and Esterases

Chemical Reviews, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +2 more sources

Selection, design, and engineering of therapeutic antibodies

Journal of Allergy and Clinical Immunology, 2005
mAbs account for an increasing portion of marketed human biological therapeutics. As a consequence, the importance of optimal selection, design, and engineering of these not only has expanded in the past 2 decades but also is now coming into play as a competitive factor.
openaire   +2 more sources

Molecular engineering and design of therapeutic antibodies

Current Opinion in Immunology, 2008
Since the first murine monoclonal antibody was approved for human therapeutic use over a decade ago, the realization that monoclonal antibody therapeutics could be engineered to improve their efficacy has inspired an astonishing array of novel antibody constructs.
openaire   +2 more sources

Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies

Ca-A Cancer Journal for Clinicians, 2022
Shanu Modi, Cortes J, Roberto Carmagnani Pestana   +2 more
exaly  

Avidity in antibody effector functions and biotherapeutic drug design

Nature Reviews Drug Discovery, 2022
Paul Parren, Simone Oostindie, Janine Schuurman   +2 more
exaly  

Accelerating antibody discovery and design with artificial intelligence: Recent advances and prospects

Seminars in Cancer Biology, 2023
Bai Ganggang, Buyong Ma, Chuance Sun
exaly  

Catalytic antibodies: designed and accidental

Biochemical Society Transactions, 1993
Colin J. Suckling, William H. Stimson, George R. Proctor, Laura H. Bence, Linda Brooks, Abedawn L. Khalaf, Catriona M. Tedford, Sabin Linaza, Iain McGilp, Raymond Maguire, June Irvine   +10 more
openaire   +2 more sources

Considerations for the Design of Antibody-Based Therapeutics

Journal of Pharmaceutical Sciences, 2020
William Atkins, Dennis Goulet
exaly  

How to Design Antibodies

A step-by-step guide to making de novo binders.
openaire   +1 more source