Results 111 to 120 of about 256,130 (281)

Antibody Engineering for Nuclear Imaging and Radioimmunotherapy. [PDF]

J Nucl Med, 2022
Rodriguez C, Delaney S, Sarrett SM, Keinänen OM, Zeglis BM.   +4 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Special Issue "Antibody Engineering for Cancer Immunotherapy". [PDF]

Antibodies (Basel), 2022
Crescioli S, White AL, Karagiannis SN.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Monte Carlo Thompson sampling-guided design for antibody engineering. [PDF]

MAbs, 2023
Kakuzaki T, Koga H, Takizawa S, Metsugi S, Shiraiwa H, Sampei Z, Yoshida K, Tsunoda H, Teramoto R.   +8 more
europepmc   +1 more source

Engineering Antibody Fitness and Function Using Membrane-Anchored Display of Correctly Folded Proteins

, 2011
Amy J. Karlsson, Hyung-Kwon Lim, Hansen Xu, Mark A. Rocco, Matthew Bratkowski, Ailong Ke, Matthew P. DeLisa   +6 more
openalex   +2 more sources

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies [PDF]

, 2013
Andrew T. McGuire, Sam Hoot, Anita M. Dreyer, Adriana Lippy, Andrew B. Stuart, Kristen W. Cohen, Joseph G. Jardine, Sergey Menis, Johannes F. Scheid, Anthony P. West, William R. Schief, Leonidas Stamatatos   +11 more
openalex   +1 more source

A Review of Protein-Based COVID-19 Vaccines: From Monovalent to Multivalent Formulations

Vaccines
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulting in the COVID-19 pandemic, has profoundly impacted global healthcare systems and the trajectory of economic advancement.
Gui Qian, Cuige Gao, Miaomiao Zhang, Yuanxin Chen, Liangzhi Xie   +4 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Unlocking the potential of agonist antibodies for treating cancer using antibody engineering. [PDF]

Trends Mol Med, 2023
Jhajj HS, Lwo TS, Yao EL, Tessier PM.
europepmc   +1 more source