Results 71 to 80 of about 425,308 (294)

Tim-3 protects against cisplatin nephrotoxicity by inhibiting NF-κB-mediated inflammation

Cell Death Discovery, 2023
The impact of Tim-3 (T cell immunoglobulin and mucin domain-containing protein 3) on cisplatin-induced acute kidney injury was investigated in this study.
Peiyao Li, Xuemiao Li, Wenbin Wu, Mengjia Hou, Guanyi Yin, Zhonghang Wang, Ziyu Du, Yuanfang Ma, Qiang Lou, Yinxiang Wei   +9 more
doaj   +1 more source

In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction [PDF]

, 2010
We investigated whether human articular chondrocytes can be labeled efficiently and for long-term with a green fluorescent protein (GFP) lentivirus and whether the viral transduction would influence cell proliferation and tissue-forming capacity.
Acharya, Chitrangada, Barbero, Andrea, Candrian, Christian, Gianni-Barrera, Roberto, Jaquiery, Claude, Juelke, Henriette, Mainil-Varlet, Pierre, Martin, Ivan, Miot, Sylvie, Pelttari, Karoliina   +9 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen

mAbs, 2020
Complement-dependent cytotoxicity (CDC) is a potent effector mechanism, engaging both innate and adaptive immunity. Although strategies to improve the CDC activity of antibody therapeutics have primarily focused on enhancing the interaction between the ...
Bo Wang, Chunning Yang, Xiaofang Jin, Qun Du, Herren Wu, William Dall’Acqua, Yariv Mazor   +6 more
doaj   +1 more source

Human Galectins Induce Conversion of Dermal Fibroblasts into Myofibroblasts and Production of Extracellular Matrix: Potential Application in Tissue Engineering and Wound Repair [PDF]

, 2011
Members of the galectin family of endogenous lectins are potent adhesion/growth-regulatory effectors. Their multi-functionality opens possibilities for their use in bioapplications. We studied whether human galectins induce the conversion of human dermal
André A., S., André K., S., Barbora Dvořánková, Bergmann J., M., Cheb Y.-Y., S.-J., Dam T.K., Demetter O., P., Dvoránková J., B., Engelhardt H.-J., R., Eva Sykova, Fischer H., C., Fritz A., P., Hans-Joachim Gabius, Herbert Kaltner, Hung C.W., Jana Uhrova, Jones D.L., Jones G.E., Jones G.E., Karel Smetana, Jr., Kim Y.-B., H.-W., Kojima S., S., Lacina H., L., Lacina J., L., Lataillade T., J.-J., Legendre N., H., Lensch A., M., Lu J., Z.-H., Lukas Lacina, Miller S.N., Nagy I., N., Nakachi Y., K., Nogales-Gonzalés A., A., O’Donoghue J., K., Pavol Szabo, Pei S., Z., Peter Gal, Sabine André, Sanchez-Ruderisch C., H., Sanchez-Ruderisch S., H., Sansone S., F., Seyrek H., K., Smetana B., K., Smetana L., K., Smetana Z., K., Tomas Zima, Uchida K., K., von Reitzenstein J., C.   +47 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Secretion and assembly of functional mini-cellulosomes from synthetic chromosomal operons in Clostridium acetobutylicum ATCC 824. [PDF]

, 2013
Background: Consolidated bioprocessing (CBP) is reliant on the simultaneous enzyme production, saccharification of biomass, and fermentation of released sugars into valuable products such as butanol. Clostridial species that produce butanol are, however,
Bolam, DN, Heap, JT, Jackson, A, Kovács, K, Minton, NP, Schwarz, K, Willson, BJ, Winzer, K   +7 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Diminished but Not Abolished Effect of Two His351 Mutants of Anthrax Edema Factor in a Murine Model

Toxins, 2016
Edema toxin (ET), which is composed of a potent adenylate cyclase (AC), edema factor (EF), and protective antigen (PA), is one of the major toxicity factors of Bacillus anthracis.
Taoran Zhao, Xinghui Zhao, Ju Liu, Yingying Meng, Yingying Feng, Ting Fang, Jinlong Zhang, Xiuxu Yang, Jianmin Li, Junjie Xu, Wei Chen   +10 more
doaj   +1 more source

Digital microarrays: single-molecule readout with interferometric detection of plasmonic nanorod labels [PDF]

, 2018
DNA and protein microarrays are a high-throughput technology that allow the simultaneous quantification of tens of thousands of different biomolecular species.
Daaboul, George G., Kanik, Fulya Ekiz, Sevenler, Derin, Unlu, M. Selim, Unlu, Nese Lortlar   +4 more
core   +1 more source