Results 41 to 50 of about 6,877,966 (373)

Analysis of immune network dynamical system model with small number of degrees of freedom [PDF]

open access: yes, 2000
We numerically study a dynamical system model of an idiotypic immune network with a small number of degrees of freedom. The model was originally introduced by Varela et.al., and describes antibodies interacting in a body in order to prepare for the invasion of external antigens. The main purpose of this paper is to investigate the direction of change
arxiv   +1 more source

ASAP-SML: An Antibody Sequence Analysis Pipeline Using Statistical Testing and Machine Learning [PDF]

open access: yes, 2020
Antibodies are capable of potently and specifically binding individual antigens and, in some cases, disrupting their functions. The key challenge in generating antibody-based inhibitors is the lack of fundamental information relating sequences of antibodies to their unique properties as inhibitors.
arxiv   +1 more source

The Effectiveness of Vaccination in Sickly Children with Disorders of the Central Nervous System

open access: yesЭпидемиология и вакцинопрофилактика, 2015
Data on the current vaccination process have in sickly children with disorders of the central nervous system, and grafted lifeless live vaccines against diphtheria, measles and mumps.The levele of intercurrent diseases in every group was 33,3%.
S. P. Kaplina   +2 more
doaj   +1 more source

When Two are Better than One: Modeling the Mechanisms of Antibody Mixtures [PDF]

open access: yes, 2019
It is difficult to predict how antibodies will behave when mixed together, even after each has been independently characterized. Here, we present a statistical mechanical model for the activity of antibody mixtures that accounts for whether pairs of antibodies bind to distinct or overlapping epitopes.
arxiv   +1 more source

Dynamic Optimization for Monoclonal Antibody Production [PDF]

open access: yesarXiv, 2023
This paper presents a dynamic optimization numerical case study for Monoclonal Antibody (mAb) production. The fermentation is conducted in a continuous perfusion reactor. We represent the existing model in terms of a general modeling methodology well-suited for simulation and optimization. The model consists of six ordinary differential equations (ODEs)
arxiv  

Liraglutide treatment is associated with a low frequency and magnitude of antibody formation with no apparent impact on glycemic response or increased frequency of adverse events: results from the Liraglutide Effect and Action in Diabetes (LEAD) trials.

open access: yesJournal of Clinical Endocrinology and Metabolism, 2011
CONTEXT Therapeutic proteins/peptides can produce immunogenic responses that may increase the risk of adverse events or reduce efficacy. OBJECTIVE The objectives were to measure and characterize antibody formation to liraglutide, a glucagon-like ...
J. Buse   +7 more
semanticscholar   +1 more source

Immunological efficacy of Vaccination against Measles in Children with Down syndrome

open access: yesЖурнал инфектологии, 2014
The data of current vaccination process of cellular, humoral immunity and specific antibody formation in 41 children with Down syndrome at the age of 1 year to 6 years old is observed.
S. P. Kaplina   +2 more
doaj   +1 more source

Improving antibody language models with native pairing [PDF]

open access: yesarXiv, 2023
Current antibody language models are limited by their use of unpaired antibody sequence data and the biases in publicly available antibody sequence datasets, which are skewed toward antibodies against a relatively small number of pathogens. A recently published dataset (by Jaffe, et al) of approximately 1.6 x 10^6 natively paired human antibody ...
arxiv  

Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity [PDF]

open access: yes, 2020
Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4-CXCL4) and polyanions (P) opsonize PF4-coated bacteria hereby mediating bacterial host defense. A subset of these antibodies may activate platelets after binding to PF4-heparin complexes, causing the prothrombotic adverse drug reaction heparin-induced thrombocytopenia (HIT).
arxiv   +1 more source

AntiBARTy Diffusion for Property Guided Antibody Design [PDF]

open access: yesarXiv, 2023
Over the past decade, antibodies have steadily grown in therapeutic importance thanks to their high specificity and low risk of adverse effects compared to other drug modalities. While traditional antibody discovery is primarily wet lab driven, the rapid improvement of ML-based generative modeling has made in-silico approaches an increasingly viable ...
arxiv  

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