Results 61 to 70 of about 7,305,993 (392)

Do female and male patients with cervical dystonia respond differently to long-term botulinum neurotoxin therapy?

open access: yesFrontiers in Neurology
BackgroundIdiopathic cervical dystonia (CD) affects more female than male patients. This sex-based influence on the clinical manifestation of CD may also affect outcomes after long-term BoNT therapy.MethodsTo analyze the potential differential influence ...
Harald Hefter   +5 more
doaj   +1 more source

Autophagy processes are dependent on EGF receptor signaling [PDF]

open access: yes, 2018
Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina   +12 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Effects of a monoclonal antibody against (pro)renin receptor on gliomagenesis

open access: yesScientific Reports, 2023
Glioblastoma is characterized by a strong self-renewal potential and poor differentiated state. We have reported previously that the (pro)renin receptor [(P)RR] is a potential target for glioma therapy by silencing the (P)RR gene.
Takeshi Fujimori   +10 more
doaj   +1 more source

A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. [PDF]

open access: yes, 1993
Using an in vivo test system, the role of the β1 integrin very late activation antigen-4 (VLA-4) in eosinophil accumulation in allergic and nonallergic inflammatory reactions was investigated.
Lobb, RR   +3 more
core   +1 more source

Immunomodulatory gene therapy prevents antibody formation and lethal hypersensitivity reactions in murine pompe disease.

open access: yesMolecular Therapy, 2010
Infantile Pompe disease progresses to a lethal cardiomyopathy in absence of effective treatment. Enzyme-replacement therapy (ERT) with recombinant human acid alpha-glucosidase (rhGAA) has been effective in most patients with Pompe disease, but efficacy ...
Baodong Sun   +11 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans

open access: yeseLife, 2021
Antibody production following vaccination can provide protective immunity to subsequent infection by pathogens such as influenza viruses. However, circumstances where antibody formation is impaired after vaccination, such as in older people, require us ...
Danika L Hill   +12 more
doaj   +1 more source

Tentacle morphogenesis in hydra [PDF]

open access: yes, 1990
Stimulation of tentacle-specific cell differentiation by the neuropeptide head activator was investigated in Hydra magnipapillata. Tentacle-specific sensory nerve cells were identified by a monoclonal antibody, NV1.
David, Charles N.   +2 more
core   +1 more source

Subinhibitory concentrations of trimethoprim and sulfamethoxazole prevent biofilm formation by Acinetobacter baumannii through inhibition of Csu pilus expression [PDF]

open access: yes, 2017
Acinetobacter baumannii is emerging as a multidrug-resistant nosocomial pathogen of increasing threat to human health worldwide. Pili are important bacterial virulence factors, playing a role in attachment to host cells and biofilm formation.
Feldman, Mario F   +2 more
core   +2 more sources

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