Results 231 to 240 of about 447,696 (288)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

CSF Anti-Sjögren's Syndrome Antigen A Antibodies and Low Glucose Levels in Sjögren's Syndrome-Associated Aseptic Meningitis: A Case Report. [PDF]

Cureus
Ueno T, Hiyama K, Yanagida R, Miura M, Arai A.   +4 more
europepmc   +1 more source

Correlation of pemphigus disease area index and anti-desmoglein antibody index in pemphigus vulgaris patients

Journal of the Egyptian Womenʼs Dermatologic Society, 2013
openaire   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Refractory severe type B insulin resistance treated with daratumumab. [PDF]

JCEM Case Rep
Munugoti S, Gaddam M, Rasool N, Shevtsov P, Piranavan P, Kern PA.   +5 more
europepmc   +1 more source

Antibody Engineering through Fc Glycans for Improved Therapeutic Index [PDF]

, 2016
openaire   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Case Report: Anti-LGI1 encephalitis during FcRn inhibition with efgartigimod for myasthenia gravis: implications for the limitations of IgG recycling blockade. [PDF]

Front Immunol
Komatsu Y, Eura N, Nishimori Y, Kakehi Y, Kiriyama T, Sugie K.   +5 more
europepmc   +1 more source

Analysis of risk factors for hypothyroidism in initially euthyroid patients with positive thyroid autoantibodies: a multicenter retrospective cohort study. [PDF]

Front Endocrinol (Lausanne)
Feng X, Lyu X, Gao Y, Gao X, Gao R.
europepmc   +1 more source